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| 1 | 男性性功能障碍、男性不育与神经系统疾病之间的关系显示文摘正常的性功能和生殖功能很大程度上依赖于神经系统功能的正常发挥。男性神经系统受损可导致勃起功能障碍、射精障碍和精液异常,进而导致不育。出现这些受损的主要原因有盆腔和腹腔损伤、糖尿病、先天性脊柱异常,多发性硬化症和脊髓受损。勃起功能障碍已经可以通过越来越具侵入式的治疗方法而有所改善,从药物疗法、注射疗法到外科的阴茎植入术。病情较轻的逆行射精患者可以用药物来逆转条件进行治疗,对病情较重的患者,则在射精后从其膀胱中收取精液。对于中度的不射精者,可以采用药物治疗:而对于严重者,则可采用阴茎震荡刺激和电射精等辅助射精技术。假如这些措施都失败了,可尝试采用手术方法取精液。对于一些脊髓受损的男性,假如环境条件和精液质量足够好,可在家中采用阴茎震荡刺激,然后将精液放入伴侣阴道内。其他方法就要求助于辅助生殖技术了,包括宫内受精和体外受精(用ICSI或者不用)。选用何种方法在很大程度上依赖于患者精液中活性精子的数量。 | Mikkel Fode Sheila Krogh-Jespersen Nancy L Brackett Dana A Ohl Charles M Lynne Jens Sonksen | 2012 | Asian Journal of Andrology2012，14，1： | 7 |
| 2 | Importance of fatigue and its measurement in chronic liver disease显示文摘The mechanisms of fatigue in the group of people with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are protean. The liver is central in the pathogenesis of fatigue because it uniquely regulates much of the storage, release and production of substrate for energy generation. It is exquisitely sensitive to the feedback controlling the uptake and release of these energy generation substrates. Metabolic contributors to fatigue, beginning with the uptake of substrate from the gut, the passage through the portal system to hepatic storage and release of energy to target organs (muscle and brain) are central to understanding fatigue in patients with chronic liver disease. Inflammation either causing or resulting from chronic liver disease contributes to fatigue, although inflammation has not been demonstrated to be causal. It is this unique combination of factors, the nexus of metabolic abnormality and the inflammatory burden of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis that creates pathways to different types of fatigue. Many use the terms central and peripheral fatigue. Central fatigue is characterized by a lack of self-motivation and can manifest both in physical and mental activities. Peripheral fatigue is classically manifested by neuromuscular dysfunction and muscle weakness. Therefore, the distinction is often seen as a difference between intention (central fatigue) versus ability (peripheral fatigue). New approaches to measuring fatigue include the use of objective measures as well as patient reported outcomes. These measures have improved the precision with which we are able to describe fatigue. The measures of fatigue severity and its impact on usual daily routines in this population have also been improved, and they are more generally accepted as reliable and sensitive. Several approaches to evaluating fatigue and developing endpoints for treatment have relied of biosignatures associated with fatigue. These have been used singly or in combination and include: physical performance measures, cognitive performance measures, mood/behavioral measures, brain imaging and serological measures. Treatment with non-pharmacological agents have been shown to be effective in symptom reduction, whereas pharmacological agents have not been shown effective. | Lynn H Gerber Ali A Weinstein Rohini Mehta Zobair M Younossi | 2019 | World Journal of Gastroenterology2019，25，28： | 7 |
| 3 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 4 | The Stroke Outcomes and Neuroimaging of Intracranial Atherosclerosis (SONIA) Trial显示文摘 | E Feldmann J L. Wilterdink A Kosinski M Lynn M I. Chimowitz J Sarafin H H. Smith F Nichols J Rogg H J. Cloft L Wechsler J Saver S R. Levine C Tegeler R Adams M Sloan | 2007 | Neurology2007，，24： | 2 |
| 5 | Food animal associatedSalmonella chal lenges: pathogenicity and antimicrobial resistance 显示文摘 | Foley S L Lynne A M | 2008 | J Anita Sci2008，86，： | 1 |
| 6 | High-level production of recombinant proteins in CHO cells using a dicistronic DHFR intron expression vector显示文摘 | Brian K L Lynne M G Richard A | 1996 | Nucleic Acids Research1996，24，9： | 1 |
| 7 | JAm Chem Soc 显示文摘 | Akinc A Lynn D M Anderson D G | 2003 | 125(14): 5316-53232003，125，14： | 1 |
| 8 | Ethylene interacts with acts with abscisic acid to regulate endosperm rupture during germination: a comparative approach using Lepidiumsativur and Arabidopsis thaliana 显示文摘 | Linkies A Muller K Morris K Tureckova V Wenk M Cadman CS Corbineau F Strnad M Lynn J R Finch-Savage W E Leubner-Metzger G | 2009 | Plant Cell2009，21，12： | 1 |
| 9 | Analysis of derivatized bio-genie aldehydes by LC tandem mass spectrometry显示文摘 | WII/2AMS T I LOVELL M A LYNN B C | 2005 | Analytical Chemis- try2005，77，10： | 1 |
| 10 | Cyclodextrin-Modified Gold Nanospheres显示文摘 | Liu J Ong W Román E Lynn M J Kaifer A E | 2000 | Langmuir2000，16，： | 1 |
| 11 | Mechanisms underlying NMDA receptor synaptic/extrasynaptie distribution and function 显示文摘 | Gladding Clare M Raymond Lynn A | 2011 | Mol Cell Neurosci2011，48，4： | 1 |
| 12 | Food animal-associated Salmonella challenges: pathogenicity and antimicrobial resistance 显示文摘 | Foley S L Lynne A M | 2008 | J Anim Sci2008，86，： | 1 |
| 13 | Design and NMR characterization of active analogues of compstatin containing non-natural amino acids显示文摘 | Madan K Lynn A | 2005 | J Med Chem2005，48，： | 1 |
| 14 | A design theory for systems that support emergent knowledge processes显示文摘 | LYNNE M M MAJCHRZAK A GASSER L | 2002 | MIS Quarlerly2002，26，3： | 1 |
| 15 | The PINHEAD/ZWILLEgene acts pleiotropically in Arabidopsis development andhas overlapping functions with the ARGONAUTE1 gene 显示文摘 | Lynn K Fernandez A Aida M | 1999 | Development1999，126，46： | 1 |
| 16 | Antimicrobial edible apple films inactivate antibiotic resistant and susceptible campylobacter jejuni strains on chicken breast显示文摘 | RITA M MIL D LYNN A | 2011 | Journal of Food Science2011，76，3： | 1 |
| 17 | A study of the prevalence of Helicobacter pylori infection and other markers of upper gastrointestinal tract disease in patients with rosacea 显示文摘 | SHARMA V K LYNN A KAMINSKI M | 1998 | Am J Gastroenterol1998，93，2： | 1 |
| 18 | Suspended sediment concentrations in the Tamar estuary显示文摘 | Tattersalla G R Elliotta A J Lynn N M | 2003 | Estuarine Coastal and Shelf Science2003，57，： | 1 |
| 19 | Skill in Estimation Problems of Extent and Numerosity 显示文摘 | Siegel A W Lynn T G Camilla R M | 1982 | Journal for Research in Mathematics Education1982，，13： | 1 |
| 20 | Modeling hydraulic regenerative hybrid vehicles using AMESim and Matlab/Simulink显示文摘 | Lynn A Smid E Eshraghi M | | 0，，： | 1 |
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