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| 1 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 2 | Determination of toxic elements in nuts by inductively coupled plasma mass spectrometry after microwave-induced combustion 显示文摘 | Mulle A L H Muller C C Lyra F | 2013 | Food Analytical Methods2013，6，1： | 1 |
| 3 | Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease:apilot randomized controlled study显示文摘 | LYRA A C SOARES M B DA SILVA L F | 2010 | Eur J Gastroenterol Hepatol2010，22，： | 1 |
| 4 | Clinical and epidemiological features of patients with chronic hepatitis C co-infected with HIV显示文摘 | Braga EL Lyra AC Ney-Oliveira F | 2006 | The Brazilian Journal Of Infectious Diseases2006，10，1： | 1 |
| 5 | Determination of toxic elements in nuts by inductively coupled plasma mass spectrometry after microwave-induced combustion显示文摘 | MULLE A L H MULLER C C LYRA F | 2013 | Food Anal Methods2013，6，1： | 1 |
| 6 | Delocalization in the 1D Anderson model with long-range correlated disorder显示文摘 | DEMOURA F LYRA M L | 1998 | PhysRev Lett1998，81，17： | 1 |
| 7 | A stochastic model for multifractal behavior of stock prices显示文摘 | Fulco U L Lyra M L Petroni F Serva M Viswanathan G M | 2004 | International Journal of Modem Physics B2004，18，45： | 1 |
| 8 | Comparison of surfactant pro- tein B polymorphisms of healthy term newborns with preterm newborns having respiratory distress syndrome 显示文摘 | Lyra P P Vaz F A Moreira P E | 2007 | Braz J Med Biol Res2007，40，6： | 1 |
| 9 | Determination of toxic elements in nuts by inductively coupled plasma mass spectrometry after microwave - induced combustion 显示文摘 | MulleA L H Muller C C Lyra F | 2013 | Food Analytical Methods2013，6，1： | 1 |
| 10 | Clinical and epidemiolng-ical features of patients with chronic hepatitis C co-infected with HIV显示文摘 | Braga EL Lyra AC Ney-Oliveim F | 2006 | The Bmzilian Journal Of Irdotious Diseases2006，10，1： | 1 |
| 11 | Impact of rainfed and irrigated agriculture systems on soil carbon stock under different climate scenarios in the semi-arid region of Brazil显示文摘Understanding the dynamics of soil organic carbon(SOC) is of fundamental importance in land use and management, whether in the current researches or in future scenarios of agriculture systems considering climate change. In order to evaluate SOC stock of the three districts(Delmiro Gouveia, Pariconha, and Inhapi districts) in the semi-arid region of Brazil in rainfed and irrigated agriculture systems under different climate scenarios using the Century model, we obtained RCP4.5 and RCP8.5 climate scenarios derived from the Eta Regional Climate Model(Eta-Had GEM2-ES and Eta-MIROC5) from the National Institute for Space Research, and then input the data of bulk density, p H, soil texture, maximum temperature, minimum temperature, and rainfall into the soil and climate files of the Century model. The results of this study showed that the Eta-Had GEM2-ES model was effective in estimating air temperature in the future period. In rainfed agriculture system, SOC stock under the baseline scenario was lower than that under RCP4.5 and RCP8.5 climate scenarios, while in irrigated agriculture system, SOC stock in the almost all climate scenarios(RCP4.5 and RCP8.5) and models(Eta-Had GEM2-ES and Eta-MIROC5) will increase by 2100. The results of this study will help producers in the semi-arid region of Brazil adopt specific agriculture systems aimed at mitigating greenhouse gas emissions. | André L CARVALHO Renato A ARAúJO-NETO Guilherme B LYRA Carlos E P CERRI Stoécio M F MAIA | 2022 | Journal of Arid Land2022，14，4： | 0 |
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