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| 1 | Clinical and Genetic Investigation of a Multi-generational Chinese Family Afflicted with Von Hippel-Lindau Disease显示文摘 | Jingyao Zhang Jie Ma Xiaoyun Du Dapeng Wu Hong Ai Jigang Bai Shunbin Dong Qinling Yang Kai Qu Yi Lyu Robert K Valenzuela Chang Liu | 2015 | Chinese Medical Journal2015，，1： | 6 |
| 2 | MATRIEX imaging:multiarea two-photon real-time in vivo explorer显示文摘Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian brains.However,the extent of such studies is typically confined to a single functional region of the brain.Here,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions simultaneously.For example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning device.In particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope itself.Thus,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution. | Mengke Yang Zhenqiao Zhou Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao Bing Leng Jing Lyu Kuan Zhang Min Li Yan Gong Zhiming Zhu Junan Yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia | 2019 | Light(Science & Applications)2019，8，1： | 4 |
| 3 | Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH. | Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 4 | Application of artificial neural networks in detection and diagnosis of gastrointestinal and liver tumors显示文摘As a form of artificial intelligence,artificial neural networks(ANNs)have the advantages of adaptability,parallel processing capabilities,and non-linear processing.They have been widely used in the early detection and diagnosis of tumors.In this article,we introduce the development,working principle,and characteristics of ANNs and review the research progress on the application of ANNs in the detection and diagnosis of gastrointestinal and liver tumors. | Wei-Bo Mao Jia-Yu Lyu Deep K Vaishnani Yu-Man Lyu Wei Gong Xi-Ling Xue Yang-Ping Shentu Jun Ma | 2020 | World Journal of Clinical Cases2020，8，18： | 2 |
| 5 | Microgravimetric lectin biosensor based on signal amplification using carbohydrate-stabilized gold nanoparticles显示文摘 | LYU Y K LIM K R LEE B Y | 2008 | Chem Commun2008，39，： | 1 |
| 6 | Study on positioning accuracy of nut/shaft air cooling ball screw for high- precision feed drive显示文摘 | Xu Z Z Liu X J Lyu S K | 2014 | International Journal of Precision Engineering and Manufacturing2014，15，1： | 1 |
| 7 | Catalytic synthesis and photoluminescence of gallium nitride nanowires显示文摘 | Lyu S C Cha O H Suh E K | 2003 | Chemical Physics Letters2003，，367： | 1 |
| 8 | Effects of CaF2 and CaCI2 addition on the formation of llCaO ~ 7A1203 ~ CaS solid solution in the CaO-A1203 slag显示文摘 | Lyu N N Yu J K Su C | 2013 | Metalurgia International2013，6，： | 1 |
| 9 | Spectral CT in patients with small HCC: investigation of image quality and diagnostic accuracy 显示文摘 | Lyu P Lin XZ Chen K | 2012 | Eur Radiol2012，22，10： | 1 |
| 10 | Nafion sta- bilized magnetic nanoparticles (Fe3O4) for 2+ (bpy= bipyridine) electrogenerated chemi- luminescence sensor显示文摘 | KIM D J LYU Y K CHOI H N | 2005 | Chem Comm2005，23，： | 1 |
| 11 | Wnt-Ta up-regulates matrix metalloproteinase-12 ex- pression and promotes cell proliferation in corneal epithelial ceils dur- ing wound healing 显示文摘 | Lyu J Joo C K | 2005 | J Biol Chem2005，280，21： | 1 |
| 12 | Technical note: development of Hemipyrellia ligurriens ( Wiedemarm ) ( Diptera: Calliphoridae ) at constant temperatures: applications in estimating postmortem interval显示文摘 | Yang Y Q Lyu Z Li X B Li K Yao L Wan L H | 2015 | Forensic Sci Int2015，253，： | 1 |
| 13 | Decomposition-based assembly synthesis of a three-dimensional body-in-white model for structural stiffness显示文摘 | LYU N SAITOU K | 2005 | Journal of Mechanical Design2005，127，1： | 1 |
| 14 | Eleetrophysiologieal features of Hirayama disease显示文摘 | Lyu R K Huang Y C Wu Y R | 2011 | Muscle Nerve2011，44，2： | 1 |
| 15 | Highly stable meso- porous metal oxides using nano-propping hybrid gemini sur{etants显示文摘 | Lyu Y Y Yi S H Shon J K | 2004 | Journal of the American Chemical Socie- ty2004，126，8： | 1 |
| 16 | Clinical characteristics of multiple sclerosis in Taiwan:a cross-sectional study显示文摘 | Chang K H Lyu R K Chen C M | 2006 | Multiple Sclerosis2006，12，4： | 1 |
| 17 | Mapping of the human and mouse bone sialoprotein and osteopontin loci 显示文摘 | Crosby AH Lyu MS Lin K | 1996 | Mamm Genome1996，7，2： | 1 |
| 18 | Long term operation of pilotscale biological m,trien! removal process in Ireating municipal wastewaler 显示文摘 | Kim D Kim K Y l'lyu H D | 2009 | Bioresour Technol2009，100，13： | 1 |
| 19 | Fine coal slurries by gel extraction显示文摘 | Gehrke S H Lyu L H Barnthouse K Dewatering | 1998 | Separation Science and Technology1998，33，10： | 1 |
| 20 | Experiments and analysis on LBE steady natural circulation in a rectangular shape loop显示文摘 | Li Y Lyu K F Chen L L | 2015 | Progress in Nuclear Energy2015，81，： | 1 |
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