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| 1 | 外显子测序识别脑干胶质瘤体细胞获得性功能PPM1D基因突变显示文摘发生于脑干和丘脑的胶质瘤是一类毁灭性肿瘤,难以通过手术切除。为确定这些肿瘤的遗传和表观遗传学背景,作者对14例脑干胶质瘤( BSGs)和12例丘脑胶质瘤病例进行外显子组测序。同时该团队通过针对性突变分析对另外24例该类肿瘤及45例脑胶质瘤进行全基因组甲基化谱进行分析。这项研究发现肿瘤特异性突变PPM1D,该突变编码野生型p53蛋白诱导的蛋白磷酸酶1D(WIP1),其在37.5%的脑干胶质瘤中存在标志性的H3F3A基因突变导致编码第27号染色体使赖氨酸转换为甲硫氨酸。脑干胶质瘤中PPM1D基因突变和TP53基因突变互斥抑制并且在体外实验中可以衰减p53蛋白活化。 PPM1D基因突变能够缩短外显子6来增强PPM1D抑制DNA损伤反应的检验CHK2蛋白激活的能力。这些研究结果表明PPM1D可以作为体细胞突变常用的靶点以及脑干胶质瘤治疗中的潜在靶点。 | Zhang L Chen L H Wan H 王晶晶 许春伟 张博 | 2014 | 临床与实验病理学杂志2014，30，12： | 15 |
| 2 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 3 | Identification and estimation of the biomass burning contribution to Beijing aerosol using levoglucosan as a molecular marker显示文摘 | Ting Zhang Magda Claeys Hélène Cachier Shuping Dong Wan Wang Willy Maenhaut Xiande Liu | 2008 | Atmospheric Environment2008，，29： | 2 |
| 4 | Efficient photon coupling from a diamond nitrogen vacancy center by integration with silica fiber显示文摘A central goal in quantum information science is to efficiently interface photons with single optical modes for quantum networking and distributed quantum computing.Here,we introduce and experimentally demonstrate a compact and efficient method for the low-loss coupling of a solid-state qubit,the nitrogen vacancy(NV)center in diamond,with a single-mode optical fiber.In this approach,single-mode tapered diamond waveguides containing exactly one high quality NV memory are selected and integrated on tapered silica fibers.Numerical optimization of an adiabatic coupler indicates that near-unity-efficiency photon transfer is possible between the two modes.Experimentally,we find an overall collection efficiency between 16%and 37%and estimate a single photon count rate at saturation above 700 kHz.This integrated system enables robust,alignment-free,and efficient interfacing of single-mode optical fibers with single photon emitters and quantum memories in solids. | Rishi N Patel Tim Schröder Noel Wan Luozhou Li Sara L Mouradian Edward H Chen Dirk R Englund | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 5 | Clinical measures of disease severity and outcome in psoriasis:a critical appraisal of their quality显示文摘 | ASHCROFT D M WAN PO A L WILLIAMS H C | 1999 | Br J Dermatol1999，141，2： | 1 |
| 6 | Protection of le- thal toxicity of endotoxin by Salvia miltiorrhiza BUNGE is via reduction in tumor necrosis factor alpha release and liver injury显示文摘 | WAN J M SIT W H LEE C L | 2006 | International immunop- harmaeology2006，6，： | 1 |
| 7 | Neck circumference positively related with central obesity, overweight, and metabolic syndrome in Chinese subjects with type 2 diabetes: Beijing Community Diabetes Study 4 显示文摘 | Yang G R Yuan S Y Fu H J Wan G Zhu L X Bu X L | 2010 | Diabetes Care2010，33，： | 1 |
| 8 | Dietary methionine requirement of large yellow croaker, Pseudosciaena crocea R 显示文摘 | MAI K S WAN J L AI Q H | 2006 | Aquaculture2006，253，1234： | 1 |
| 9 | Gold hollow nanospheres : Tuna- ble surface plasmon resonance controlled by interior-cavity sizes 显示文摘 | Liang H P Wan L J Bai C L | 2005 | J Phys Chem B2005，109，16： | 1 |
| 10 | Dietary methionine requirement of large yellow croaker ( Pseudosciaena crocea R) 显示文摘 | Mai K S Wan J L Ai Q H | 2006 | Aquaculture2006，253，14： | 1 |
| 11 | Super-hydrophilicproperties of TiO 2 -DLC nanocomposite films fabricated by the sim-ple electrochemical process显示文摘 | Wan S H Wang L P Xue Q J | 2011 | Applied Surface Science2011，257，10： | 1 |
| 12 | Supramolecular control of the branched topology of poly( sulfone - amine) from divinylsullone and hexamethylenediamine 显示文摘 | Wan H Chen Y Chen L | 2008 | Macromolecules2008，41，2： | 1 |
| 13 | Preparation and properties of a novel polytriazole resin显示文摘 | Wan L Q Hu Y H Huang F R Du L | 2007 | Journal of Applied polymer Science2007，104，2： | 1 |
| 14 | On the structure-function relationship of nitrogennse M-cluster and P-cluster pairs 显示文摘 | Tsai K R Wan H L | 1995 | Journal of Cluster Science1995，6，4： | 1 |
| 15 | Preparation and characterization of rare earth orthovanadates for propane oxidative dehydrogenation 显示文摘 | Au C T Zhang W D Wan H L | 1996 | Catal Lett1996，37，： | 1 |
| 16 | A onepass thinning algorithm and its parallel implementation显示文摘 | CHIN R T WAN G H K Stover D L | 1987 | Computer Vision Graphics Image Process-ing1987，40，1： | 1 |
| 17 | Nano-effects,quantum-like properties in electrospun nanofibers显示文摘 | HE J H WAN Y Q XU L | 2007 | Chaos Solitons & Fractals2007，33，1： | 1 |
| 18 | Absorption Rate into a MDEA Aqueous Solution Blended with Piperazine under a High CO_2 Partial Pressure显示文摘 | Zhang X Wan H L Weng W Z Yi X D | | 0，，1： | 1 |
| 19 | Formation and evolution of Tanlu fault belt 显示文摘 | Wan T F Zhu H Zhao L | | Geoscience0，10，2： | 1 |
| 20 | Giant magnetoelectric effect of a hybrid of magnetostrictive and piezoelectric composites 显示文摘 | WAN J G LIU J M CHAND H L W | 2003 | J Appl Phys2003，93，： | 1 |
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