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| 1 | Diagnosis and treatment of acute pulmonary inflammation in critically ill patients: The role of inflammatory biomarkers显示文摘Pneumonia and acute respiratory distress syndrome are common and important causes of respiratory failure in the intensive care unit with a significant impact on morbidity, mortality and health care utilization despite early antimicrobial therapy and lung protective mechanical ventilation. Both clinical entities are characterized by acute pulmonary inflammation in response to direct or indirect lung injury. Adjunct anti-inflammatory treatment with corticosteroids is increasingly used, although the evidence for benefit is limited. The treatment decisions are based on radiographic, clinical and physiological variables without regards to inflammatory state. Current evidence suggests a role of biomarkers for the assessment of severity, and distinguishing sub-phenotypes (hyperinflammatory versus hypo-inflammatory) with important prognostic and therapeutic implications. Although many inflammatory biomarkers have been studied the most common and of interest are C-reactive protein, procalcitonin, and pro-inflammatory cytokines including interleukin 6. While extensively studied as prognostic tools (prognostic enrichment), limited data are available for the role of biomarkers in determining appropriate initiation, timing and dosing of adjunct anti-inflammatory treatment (predictive enrichment) | Sarah Chalmers Ali Khawaja Patrick M Wieruszewski Ognjen Gajic Yewande Odeyemi | 2019 | World Journal of Critical Care Medicine2019，8，5： | 12 |
| 2 | 2型糖尿病患者采用血管紧张素转换酶抑制剂治疗后血清肌酐急性升高及其继续治疗对主要临床结局的影响显示文摘血管紧张素转换酶抑制剂开始治疗后血清肌酐急性升高≥30%时推荐停药。但血清肌酐升高后继续服药或停药对主要临床结局的长期影响仍不明确。在ADVANCE(糖尿病与血管疾病行动:培哚普利-吲达帕胺与达美康缓释片对照评估)试验中,11 140例糖尿病患者在6周活性导入期后随机采用培哚普利-吲达帕胺或安慰剂治疗。 | Ohkuma T Jun M Rodgers A Cooper ME Glasziou P Hamet P Harrap S Mancia G Marre M Neal B Perkovic V Poulter N Williams B Zoungas S Chalmers J Woodward M 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，1： | 6 |
| 3 | 成年人及儿童重型血友病A患者凝血因子Ⅷ的预防性应用指南显示文摘本指南以文献为依据,以专家共识为基础,介绍在重型血友病A的儿童和成年人患者中预防性使用凝血因子Ⅷ(FⅧ)的作用。指南就预防性使用FⅧ的起始时机、预防方案的选择、治疗过程中的监测、突发出血时的处理,以及患者和家属的教育等问题进行了讨论。 | Richards M Williams M Chalmers E 练丽琴(节译) 梁洁芳(节译) 李玲(节译) 曾森强(节译) 范晓蔚(节译) 叶铁真(审校) | 2011 | 国际输血及血液学杂志2011，34，4： | 3 |
| 4 | 胎儿及新生儿血友病管理指南显示文摘本文提出基于循证医学、针对胎儿及新生儿血友病的管理指南,包括妊娠、分娩及新生儿早期血友病管理,并就分娩方式与颅内及颅外出血风险之间的关系进行了专门讨论。 | Chalmers E Williams M Brennand J 林慧玲(编译) 朱欢欢(编译) 叶铁真(审校) | 2011 | 国际输血及血液学杂志2011，34，4： | 3 |
| 5 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 6 | 糖尿病患者累积收缩压负荷与心血管病风险的关系显示文摘该研究旨在评估2型糖尿病患者累积收缩压负荷与心血管事件风险的关系。方法:对百普乐和达美康缓释片对糖尿病和血管疾病的对照评估试验的观察性研究(action in diabetes and vascular disease preterax and diamicron MR controlled evaluation post trial observational study, ADVANCE-ON)中的2型糖尿病患者进行事后分析。 | Wang N Harris K Hamet P Harrap S Mancia G Poulter N Williams B Zoungas S Woodward M Chalmers J Rodgers A 刘青(译) 郑武洪(审校) | 2022 | 中华高血压杂志2022，30，12： | 2 |
| 7 | Investigation of the role of companion animals in the zoonotic transmission of cryptosporidiosis显示文摘 | Smith R P Chalmers R M Elwin K | 2009 | Zoonoses Public Health2009，56，1： | 1 |
| 8 | Design and Realization of GA-Optimized Wire Monopole and Matching Network With 20:1 Bandwidth显示文摘 | Shawn D Rogers Chalmers M Butler Anthony Q Martin | | 0，，03： | 1 |
| 9 | Se- quence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain 显示文摘 | Blomqvist M E Chalmers K Andreasen N | 2005 | Neurobiol Aging2005，26，6： | 1 |
| 10 | The organic matter distribution and methane capacity of the Lower Cretaceous strata of Northeastern British Columbia, Canada显示文摘 | Chalmers G R L Bustin R M | 2007 | Int J Coal Geol2007，70，2： | 1 |
| 11 | Improved detection systems for TY virus reveal high prevalence in humans, non - human primates and farm animals 显示文摘 | LEARY T P ERKER J C CHALMERS M L | 1999 | J Gen Virol1999，80，： | 1 |
| 12 | Lower target blood pressures are safe and effective for the prevention of recurrent stroke : the PROGRESS trial 显示文摘 | Arima H Chalmers J Woodward M | 2006 | J Hypertens2006，24，6： | 1 |
| 13 | Lower Cretaceous gas shales in northeastern British Columbia,Part Ⅰ:geological controls on methane sorption capacity显示文摘 | Chalmers G R L Bustin R M | | 0，，01： | 1 |
| 14 | Characterization of gas shale pore systems by porosimetry,pycnometry,surface area,and field emission scanning electron microscopy/transmission electron microscopy image analyses:Examples from the Barnett,Woodford,Haynesville,Marcellus,and Doig units显示文摘 | Chalmers G R Bustin P M Power L M | 2012 | AAPG Bulletin2012，96，6： | 1 |
| 15 | Lower Cretaceous gas shales in Northeastern British Columbia, Part I: Geological controls on methane sorption capacity显示文摘 | Chalmers G R L Bustia R M | 2008 | Bull Can Pet Geol2008，56，1： | 1 |
| 16 | Characteristics,management and response to alteplase in China versus non-China participants of the ENCHANTED trial显示文摘Background The characteristics of patients with acute ischaemic stroke(AIS)and their management vary across regions,which may influence outcomes.We examined for differential patterns of outcome between China and non-China participants of the ENhanced Control of Hypertension And Thrombolysis strokE stuDy(ENCHANTED),which tested different alteplase doses in AIS.Methods ENCHANTED was an international,multicentre,open,blinded-endpoint trial of the effects of low-dose(0.6 mg/kg)versus standard-dose(0.9 mg/kg)intravenous alteplase on 90-day disability outcomes and symptomatic intracerebral haemorrhage(sICH)in 3310 patients with AIS.Results Participants(n=1419,48%)in China were younger,and more often male,hypertensive and with prior stroke and coronary artery disease,but less likely to have atrial fibrillation and use antihypertensive,antithrombotic and lipid-lowering agents,compared with non-China patients with AIS.Although China participants had more AIS due to large artery occlusion,were treated later and had differing ancillary management,there was no significant difference in 90-day modified Rankin scale scores 2–6(55.6% vs 47.8%;OR,adjusted for baseline and management factors 0.87(95%CI 0.71 to 1.07;p=0.20))and risk of sICH(Safe Implementation of Thrombolysis in Stroke-Monitoring Study criteria:1.4% vs 1.8%;p=0.12)compared with non-China participants.There was no heterogeneity in the treatment effects of low-dose versus standard-dose alteplase between China and non-China participants.Conclusion Patients with AIS recruited to the ENCHANTED trial in China had similar outcomes in response to thrombolysis treatment despite significantly differing demographic,clinical and management factors to patients with AIS in other regions. | Lily Song Xia Wang Thompson Robinson Richard I Lindley Hisatomi Arima Pablo M Lavados Xiaoying Chen John Chalmers Craig S Anderson | 2017 | Stroke & Vascular Neurology2017，2，2： | 1 |
| 17 | Theoretical analysis of cell separation based on cell surface marker density显示文摘 | Chalmers J J Zborowski M Moore L | 1998 | Biotechnology and Bioengineerinf1998，59，1： | 1 |
| 18 | Lower Cretaceous gas shales in northeastern British Columbia, Part Ⅱ: Evaluation of regional po- tential gas resource显示文摘 | Chalmers G R L Bustin R M | 2008 | Bulletin of Canadian Petroleum Geology2008，56，1： | 1 |
| 19 | Characterization of gas shale pore systems by porosimetry, pycnmnetry, surface area, and field emis- sion scanning electron microscopy/transmission electron microscopy image analyses: examples from the Barnett, Woodford, Haynesville, Marcellus, and Doig units 显示文摘 | Chalmers G R Bustin R M Power 1 M | 2012 | AAPG Bulletin2012，96，6： | 1 |
| 20 | Geological controls on matrix permeability of Devonian Gas Shales in the Horn River and Liard basins, northeastern British Columbia, Cmada 显示文摘 | Chalmers G R L Ross D J K Bustin R M | 2012 | International Journal of Coal Geology2012，103，： | 1 |
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