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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Adler D D Carson P L Rubin J M | 1990 | Ultrasound MedBiol1990，16，6： | 1 |
| 3 | Analysis of disconnected diallel mating designs II : results from a third generation progeny test of New Zealand Radiata pine improvemenet programme 显示文摘 | J N King M J Carson | 1998 | Silvae Genetica1998，47，23： | 1 |
| 4 | The deformational history of the Larsemann Hills,Prydz Bay:the importance of the Pan-African (500 Ma) in East Antarctica显示文摘 | Dirks P H G M Carson C J Wilson C J L | 1993 | Antarctic Science1993，5，2： | 1 |
| 5 | The evidence for dietary prevention and treatment of cardiovascular disease 显示文摘 | van Horn L McCoin M Kris-Etherton P M Burke F Carson J A S Champagne C M | 2008 | Journal of the American Dietetic Association2008，108，： | 1 |
| 6 | Doppler ultrasound flow imaging in the study of breast cancer:Preliminary findings显示文摘 | Alder D D Carson P L Rubin J M | 1990 | UItrasound Med Biol1990，16，6： | 1 |
| 7 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Alder D D Carson P L Rubin J M | 1990 | Ultrasound Med boi11990，16，4： | 1 |
| 8 | Use of a polymerase chain reaction assay to detect infection with Eperythrozoon wenyoni in cattle显示文摘 | VANDERVOOT J M BOURNE C CARSON R L | 2001 | Am Vet Med Assoc2001，219，10： | 1 |
| 9 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings 显示文摘 | ADLER D D CARSON P L RUBIN J M | 1990 | Utrasound Med Biol1990，16，： | 1 |
| 10 | Hyperbaric oxygen therapy for brain injury,cerebral palsy,and stroke显示文摘 | Mc Donagh M Carson S Ash J | 2003 | Evid Rep Technol Assess(Summ)2003，，85： | 1 |
| 11 | 显示文摘 | Jolly M R Bender J W Carson J | 1998 | SPIE1998，3327，： | 1 |
| 12 | Genotype and location effects on internode length of Pinus radiata in New Zealand显示文摘 | CARSON M J INGLIS C S | 1988 | N Z J For Sci1988，18，： | 1 |
| 13 | Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial显示文摘 | Meduri GU Golden E Freire AX Taylor E Zaman M Carson S J | 2007 | Chest2007，131，4： | 1 |
| 14 | Doppler ultrasound flowimaging in the study of breast cancer:preliminary findings显示文摘 | Adler D D Carson P L Rubin J M | | 0，，06： | 1 |
| 15 | Compressional and extensional tectonics in low-medium pressure granulites from the Larsemann Hills,East Antarctica 显示文摘 | Dirks P H G M Hand M | 1995 | Geol Mag1995，132，2： | 1 |
| 16 | Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter显示文摘 | Guzman LM Belin D Carson M J | 1995 | Journal of Bacteriology1995，177，14： | 1 |
| 17 | Late-onset chronic inflammatory encephalopathy in immune competent and severe combined-immune deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor显示文摘 | Stalder AK Carson M J Pagenstecher A at el | 1998 | AmJ Pathol1998，153，3： | 1 |
| 18 | The Importance of Storage, Transfer and Collection 显示文摘 | KNOWLTON T M CARSON J W KLINZING G E | 1994 | Chemical Engineering Progress1994，90，1： | 1 |
| 19 | Prediction of internode length in Pinus radiata stands显示文摘 | GRACE J C CARSON M J | 1993 | N Z J For Sci1993，23，： | 1 |
| 20 | Efficacy and pharmaeokinetics of bacteriophage therapy in treatment of subciinieal Staphylococcus aureus mastitis in lactating dairy cattle 显示文摘 | Gill J J Paean J C Carson M E eta/ | 2006 | Antimicrobial Agents and Chemotherapy2006，50，9： | 1 |
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