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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Immunomodulation by dietary β-1,3-glucan in the brooders of the black tiger shrimp Penaeus monodon显示文摘 | Chang C F Chen H Y Su M S | 2000 | Fish Shellfish Immun2000，10，： | 2 |
| 3 | A Resonant Accel- erometer with Two-Stage Micro-Leverage Mechanisms Fabricated by SOI-MEMS Technology 显示文摘 | Susan X P Su Henry S Yang Alice M Agogino | 2005 | IEEE Sensors Journal2005，5，6： | 1 |
| 4 | Seismic behaviour of slender reinforced concrete shear walls under high axial load ratio显示文摘 | Su R K L Wong S M | 2007 | Engineering Structures2007，29，8： | 1 |
| 5 | A general method to the strong law of large numbers and its applications显示文摘 | YANG S C SU C YU K M | 2008 | Statistics & Probability Letters2008，78，6： | 1 |
| 6 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 7 | Pricing American options: A comparison of MonteCarlo simulation approaches显示文摘 | Fu M C Laprise S B Madan D B Su Y Wu R | 2001 | Journal of Computational Finance2001，4，： | 1 |
| 8 | Optimal dietary protein and lipid levels for juvenile cobia ( Rachycentron canadum)显示文摘 | Chou R L Su M S Chen H Y | 2001 | Aquaculture2001，193，： | 1 |
| 9 | Excitons and nonlinear optical spectra in conjugated polymers显示文摘 | Abe S Schreiber M Su W P | 1992 | Phys Rev B1992，45，16： | 1 |
| 10 | NAFLD may be a common underlying liver disease in patients with hepatocellular carcinoma in the United States 显示文摘 | Marrero J A Fontana R J Su G L Conjeevaram H S Emiek D M Lok A S | 2002 | Hepatology2002，36，： | 1 |
| 11 | Surface activity of perfluorodecanoly end-capped poly (ethylene oxide) and associated adsorption behavior to the air-water interface 显示文摘 | Su Z H Thomas J M Hsu S L | 1998 | Polymer1998，39，19： | 1 |
| 12 | In vitro evaluation of the implant-abutment bacterial seal:the locking taper system显示文摘 | Dibart S Warbington M Su MF | 2005 | J O- ral Maxillofac Surg2005，20，5： | 1 |
| 13 | Ge- netic diversity and drug resistance among newly diagnosed and antiretroviral treatment-naive HIV-infected individuals in western Yunnan: a hot area of viral recombination in China 显示文摘 | Chen M Ma Y Duan S Xing H Yao S Su Y Luo H Yang L Chen H Fu L Qu A Ou CY Jia M Lu L | 2012 | BMC Infect Dis2012，12，： | 1 |
| 14 | Expression and puri fication of enzymatically active forms of the human lysyl oxi dase like protein 4显示文摘 | Suk K M Sung su K Taek J S | 2003 | Journal of Biological Chemistry2003，278，52： | 1 |
| 15 | In vitro evaluation of the implant-abutment bacterial seal:the locking taper system显示文摘 | DLBART S WARBINGTON M FAN SU M | | 0，，05： | 1 |
| 16 | Enhanced power-conversion efficiency in polymer solar cells using an inverted device structure显示文摘 | HE Z Ci ZHONG C M SU S J | 2012 | Nat Photonics2012，6，9： | 1 |
| 17 | Random signal radar--a winner both in the military and civilian operating environ ments显示文摘 | Liu G S Gu H Su W M | 2003 | IEEE Transactions on Aerospace and Electronic Systems2003，39，2： | 1 |
| 18 | Optimal dietary protein level for the growth of juvenile grouper,Epinephelus malabaricus,fed semi-purified diets显示文摘 | Chen H Y Tsai J C Su M S | 1994 | Aquaculture1994，119，： | 1 |
| 19 | Multi-point forming:a flexible manufacturing method for a 3-d surface sheet显示文摘 | Li M Z Liu Y H Su S Z | 1999 | Journal of Materials Precessing Technology1999，87，： | 1 |
| 20 | 显示文摘 | Zhu J S Su D Lu X M | 2002 | J Appl Phys2002，92，9： | 1 |
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