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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress显示文摘 | Vitale M Di Matola T D'Ascoli F | 2000 | Endocrinology2000，141，2： | 1 |
| 3 | E2A-PBX1 fusion in adult acute lymphoblastic leukem ia:biological and clinical features显示文摘 | Foa R Vitale A Mancini M | 2003 | British Journal of Hematology2003，，： | 1 |
| 4 | Molecular characterization of bla (IMP-5),a new integron-borne metallo-betalactamase gene from an acinetobacter baumannii nosocomial isolate in Portugal显示文摘 | Da Silva GJ Correia M Vital C | 2002 | FEMS Microbiol Lett2002，215，1： | 1 |
| 5 | Accuracy of nurse- performed compression ultrasonography in the diagnosis of proximal symptomatic deep vein thrombosis: a prospective cohort study显示文摘 | Mumoli N Vitale J Cocciolo M | 2014 | J Thromb Haemost2014，12，4： | 1 |
| 6 | Low kickback noise techniques for CMOS latched comparators显示文摘 | FIGUEIREDO P M VITAL J C | 2004 | IEEE ISCAS2004，1，： | 1 |
| 7 | Iodide excess induces apoptosis in thyroid cells through a p53-independ- ent mechanism involving oxidative stress 显示文摘 | Vitale M Di Matola T D'Ascoli F | 2000 | Endocrinol- ogy2000，141，2： | 1 |
| 8 | Effects of mineral composition of drinking water on risk for stone formation and bone metabolism in idiopathic calcium nephrolithiasis显示文摘 | Marangella M Vitale C Petrarulo M | 1996 | Clin Sci Colch1996，91，3： | 1 |
| 9 | Biochemical approach to di- agnosis and differentiation of primary hyperoxalurias: an update 显示文摘 | Petrarulo M Vitale C Facchini P | 1998 | J Nephrol1998，1，1： | 1 |
| 10 | Venous thromboembo- lism and lung cancer: a review显示文摘 | Vitale C D'Amato M Calabrb P | 2015 | Muhidiscip Respir Med2015，10，1： | 1 |
| 11 | Consumer Trust in an Internet Store显示文摘 | JARVENPAA S TRACTINSKY N VITALE M | 2000 | Information Technology and Management2000，1，12： | 1 |
| 12 | E2A-PBX1 fusion in childhood acute lymphoblastic leulemia: biological and clinical features显示文摘 | Foa R Vitale A Mancini M | 2003 | Br J Haematol2003，120，： | 1 |
| 13 | Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress显示文摘 | VITALE M DIMATOLA T DASCOLI F | 2000 | Endocrinology2000，141，2： | 1 |
| 14 | Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves显示文摘 | VITALE N DE FEO M DE SANTO L S | 1999 | J Am Coll Cardiol1999，33，6： | 1 |
| 15 | Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress显示文摘 | Vitale M Matola TD Dascoll F | 2000 | Endocrinology2000，141，： | 1 |
| 16 | Effects of mineral composition of drinking water on risk for stone formation and bone metabolism in idiopathic calcium nephrolithiasis显示文摘 | Marangella M Vitale C Petrarulo M | 1996 | ClinSci1996，91，： | 1 |
| 17 | Effects of pulsed electric fields on microorganisms in orange juice using electric strengths of 30 and 50 kV/cm 显示文摘 | MCDONALD C J LLOYD S W VITALE M A | 2000 | J Food Sci2000，65，6： | 1 |
| 18 | Muhiorgan failure is an adaptive, endocrine- mediated metabolic response to overwhelming systemic in- flammation显示文摘 | Singer M De Santis V Vitale D | 2001 | Lancet2001，361，： | 1 |
| 19 | Bony content of oxalate in patients with primary hyperoxaluria or oxalosis-unrelated renal failure显示文摘 | Marangella M Vitale C Petrarulo M | | 0，，： | 1 |
| 20 | Bone marrow-derived mesenchymal cell dift~rentiation toward myogenic lineages: facts and perspectives显示文摘 | Galli D Vitale M Vaccarezza M | 2014 | Biomed Res lnt2014，，76： | 1 |
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