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| 1 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | POEMS syndrome (or Crow-Fukase syndrome)显示文摘 | Lagueny A Bouillot S Vital C | 2004 | Rev Neurol (Paris)2004，160，3： | 1 |
| 4 | Plasma levels of inflammatory C-reactive protein and interleukin-6 predict outcome in elderly patients with stroke显示文摘 | Silvestri A Vitale C Ferretti F | 2004 | J Am Geriatr Soc2004，52，： | 1 |
| 5 | Molecular characterization of bla (IMP-5),a new integron-borne metallo-betalactamase gene from an acinetobacter baumannii nosocomial isolate in Portugal显示文摘 | Da Silva GJ Correia M Vital C | 2002 | FEMS Microbiol Lett2002，215，1： | 1 |
| 6 | The role of the surgeon in the evolution of flexible endoscopy显示文摘 | Morgenthal C B Richards W O Dunkin B J Forde K A Vitale G Lin E | 2007 | Surg Endosc2007，21，6： | 1 |
| 7 | Effect of trimetazi- dine on quality of life in elderly patients with ischemic dilat- ed cardiomyopathy显示文摘 | Marazzi G Gebara O Vitale C | 2009 | Adv Ther2009，26，4： | 1 |
| 8 | Low kickback noise techniques for CMOS latched comparators显示文摘 | FIGUEIREDO P M VITAL J C | 2004 | IEEE ISCAS2004，1，： | 1 |
| 9 | Effects of mineral composition of drinking water on risk for stone formation and bone metabolism in idiopathic calcium nephrolithiasis显示文摘 | Marangella M Vitale C Petrarulo M | 1996 | Clin Sci Colch1996，91，3： | 1 |
| 10 | Effect of trimetazidine on quality of life in elderly patients wih ischemic dilated cardiomyopathy显示文摘 | Marazzi G Gebara O Vitale C | 2009 | Adv Ther2009，26，4： | 1 |
| 11 | Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patientsenrolled in the GIMEMA LAL 0496 protocol 显示文摘 | Vitale A Guarini A Ariola C | 2006 | Blood2006，107，： | 1 |
| 12 | Biochemical approach to di- agnosis and differentiation of primary hyperoxalurias: an update 显示文摘 | Petrarulo M Vitale C Facchini P | 1998 | J Nephrol1998，1，1： | 1 |
| 13 | Venous thromboembo- lism and lung cancer: a review显示文摘 | Vitale C D'Amato M Calabrb P | 2015 | Muhidiscip Respir Med2015，10，1： | 1 |
| 14 | Expression,activity,and subcellular localization of testicular hormone-sensitive lipase during postnatal development in the guinea pig显示文摘 | Kabbaj O Holm C Vitale ML | 2001 | Biol Reprod2001，65，2： | 1 |
| 15 | POEMS syndrome(or Crow-Fukase syndrome)显示文摘 | Lagueny A Bouillot S Vital C | 2004 | Rev Neurol(Paris)2004，160，3： | 1 |
| 16 | Cardiovascular health in the menopausal woman:impact of the timing of hor-mone replacement therapy 显示文摘 | Rosano G Vitale C Spoleti'ni I | 2012 | Climacteric2012，15，15： | 1 |
| 17 | Plasma levels of inflammatory C- reactive protein and interleukin-6 predict outcome in elderly patients with stroke 显示文摘 | Silvestri A Vitale C Ferretti F | 2004 | J Am Geriatr Soc2004，52，9： | 1 |
| 18 | Plasma levels of inflammatory C-reactive protein and intcrleukin-6 predict outcome in elderly patients with stroke 显示文摘 | Silvcstri A Vitale C Ferretti F | 2004 | J Am Geriatr Soc2004，52，： | 1 |
| 19 | Effects of mineral composition of drinking water on risk for stone formation and bone metabolism in idiopathic calcium nephrolithiasis显示文摘 | Marangella M Vitale C Petrarulo M | 1996 | ClinSci1996，91，： | 1 |
| 20 | Effects of pulsed electric fields on microorganisms in orange juice using electric strengths of 30 and 50 kV/cm 显示文摘 | MCDONALD C J LLOYD S W VITALE M A | 2000 | J Food Sci2000，65，6： | 1 |
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