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| 1 | Collagen prolyl 4-hydroxylases modify tumor progression显示文摘Collagen is the main component of the extracellular matrix.Hydroxylation of proline residues on collagen,catalyzed by collagen prolyl 4-hydroxylase(C-P4H),is essential for the stability of the collagen triple helix.Vertebrate C-P4H is anα2β2 tetramer with three isoenzymes differing in the catalyticα-subunits,which are encoded by P4HA1,P4HA2,and P4HA3 genes.In contrast,β-subunit is encoded by a single gene P4HB.The expressions of P4HAs and P4HB are regulated by multiple cellular factors,including cytokines,transcription factors,and microRNAs.P4HAs and P4HB are highly expressed in many tumors and participate in cancer progression.Several inhibitors of P4HAs and P4HB have been confirmed to have anti-tumor effects,suggesting that targeting C-P4H is a feasible strategy for cancer treatment.Here,we summarize recent progresses on the function and expression of regulatory mechanisms of C-P4H in cancer progression and point out the potential development of therapeutic strategies in targeting C-P4H in the future. | Run Shi Shanshan Gao Jie Zhang Jiang Xu Linda M.Graham Xiaowen Yang Chaoyang Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，7： | 2 |
| 2 | Three types of interaction显示文摘 | Moore M.Graham | | 0，，02： | 1 |
| 3 | Necrolytic migratory erythema with the absence of necrolysis显示文摘 | A. E.Macbeth A.James M.Rhodes L.Igali D.McGibbon R. M.Graham | 2010 | Continuing Professional Development2010，，7： | 1 |
| 4 | Speed associated with plasma pH, oxygen content, total protein and urea in an 80 km race显示文摘 | R. M.HOFFMAN T. M.HESS C. A.WILLIAMS D. S.KRONFELD K. M.GRIEWE‐CRANDELL J. E.WALDRON P. M.GRAHAM‐THIERS L. S.GAY R. K.SPLAN K. E.SAKER P. A.HARRIS | 2010 | Equine Veterinary Journal . 2010 (S34)2010，，34： | 1 |
| 5 | Using Pharmacokinetic Modeling and Electronic Health Record Data to Predict Clinical and Safety Outcomes after Methylprednisolone Exposure during Cardiopulmonary Bypass in Neonates显示文摘Background:Infants undergoing cardiac surgery with cardiopulmonary bypass(CPB)frequently receive intraoperative methylprednisolone(MP)to suppress CPB-related inflammation;however,the optimal dosing strategy and efficacy of MP remain unclear.Methods:We retrospectively analyzed all infants under 90 days-old who received intra-operative MP for cardiac surgery with CPB from 2014–2017 at our institution.We combined real-world dosing data from the electronic health record(EHR)and two previously developed population pharmacokinetic/pharmacodynamic models to simulate peak concentration(Cmax)and area under the concentration-time curve for 24 h(AUC24)for MP and the inflammatory cytokines interleukin-6(IL-6)and interleukin-10(IL-10).We evaluated the relationships between post-operative,safety,and other clinical outcomes obtained from the EHR with each predicted exposure using non-parametric tests.Results:A total of 142 infants with median post-natal age 8(interquartile range[IQR]:5,37)days received a total dose of 30(19,49)mg/kg of MP.Twelve(8%)died,37(26%)met the composite post-operative outcome,114(80%)met the composite safety outcome,and 23(16%)had a major complication.Predicted median Cmax and AUC24 IL-6 exposure was significantly higher for infants meeting the composite post-operative outcome and those with major complications.Predicted median Cmax and AUC24 MP exposure was significantly higher for infants requiring insulin.No exposure was associated with death or other safety outcomes.Conclusions:Pro-inflammatory IL-6,but not MP exposure,was associated with post-operative organ dysfunction,suggesting current MP dosing may not adequately suppress IL-6 or increase IL-10 to impact clinical outcomes.Prospective study will be required to define the optimal exposure-efficacy and exposure-safety profiles in these infants. | Henry P.Foote Huali Wu Stephen J.Balevic Elizabeth J.Thompson Kevin D.Hill Eric M.Graham Christoph P.Hornik Karan R.Kumar | 2023 | Congenital Heart Disease2023，18，3： | 0 |
| 6 | 中国公司如何突破在美国投资的“围城”显示文摘20世纪80年代,日本的公司大量吞并美国公司和资产,美国国会的成员、各种商业联盟的领袖以及企业的领导者都开始大声疾呼,“日本人来了”!尽管在美国的经济发展历史上,尤其是在19世纪70年代到1914年的后工业革命时期,国外的投资者扮演了重要的角色,评论家们还是发出警告:当日本投资者来到美国的时候,情况是不同的。当时美国国内的一些著名学者,包括雷斯特·斯若——当时麻省理工大学斯隆管理学院的主任,以及斯蒂文·福布斯一知名的出版家以及后来的总统候选人,都对日本经济发展及对美国大量投资产生的影响力可能会严重威胁美国未来的经济发展表示担心。 | Davjd M.Marchick Edward M.Graham 杨利红 | 2006 | 经济导刊2006，，10： | 0 |
| 7 | 仿效日企经验 中国公司投资美国需变形象显示文摘现在,美国国会对中国企业在美投资的增加日感不安,设置了一些门槛故意刁难。 | David M.Marchick Edward M.Graham | 2006 | IT时代周刊2006，，19： | 0 |
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