| 1 | Effects of vitamin supplementation on inflammatory markers and psychological wellbeing among distressed women:a randomized controlled trial显示文摘Background: Multivitamins are a popular supplement taken to promote physical and mental health.During periods of stress, they may have a protective role for health and wellbeing, although the current evidence of their efficacy is mixed.Objective: To determine whether multivitamin supplementation impacts psychological and inflammatory markers of women who are experiencing psychological distress.Design, setting, participants and interventions: An 8-week randomized controlled trial was conducted to assess changes in both psychological state and pro-inflammatory markers of patients receiving multivitamins or placebo. The sample comprised women who reported elevated psychological distress in the previous 4 weeks.Main outcome measures: Psychological state was assessed using Spielberger's State-Trait Personality Inventory to assess anxiety, curiosity, depression and anger. Pro-inflammatory markers comprised interleukin(IL)-1β,IL-5, IL-6, tumour necrosis factor(TNF)-α and TNF-p.Results: Improvements across time were observed for all psychological measures and cytokines, except IL-5, but were independent of the active intervention. Only TNF-β demonstrated a significant differential change between groups over the course of the intervention, in favour of multivitamin supplementation(active group mean rank decreased from 11.1 to 7.1; placebo group mean rank decreased from 8.9 to 7.8).Conclusion: The results suggest that administration of multivitamins was not effective in improving psychological state. However, some evidence supported the positive impact of multivitamin supplementation on pro-inflammatory cytokine profiles of women currently experiencing stress. | J.M.Oliver-Baxter H.S.Whitford D.A.Turnbull M.J.Bond | 2018 | Journal of Integrative Medicine2018，16，5： | 1 |
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