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| 1 | Histopathologic characterization of radioactive iodine‐refractory fluorodeoxyglucose‐positron emission tomography‐positive thyroid carcinoma显示文摘 | MichaelRivera Ronald A.Ghossein HeikoSchoder DanielGomez Steven M.Larson R. MichaelTuttle | 2008 | Cancer2008,,1: | 1 |
| 2 | 林业部门的民主分权:非洲、亚洲和拉丁美洲的经验教训显示文摘总结了约20个发展中国家林业部门分权管理的研究结果,并通过对在森林治理中起到主要作用的机构和参与者的分析,探讨了成功和失败的范例和主要的因素。本研究表明,执行民主分权的案例并不多见,表现在:真正的决策权力、森林资源及其效益仍然是集权管理、选处理的当地参与者往往不具有代表性或不负责任。现行政策有时伤害了当地的穷人。本文强调了全国性的对话和对公民社会特别是边缘群体的授权的重要性。研究结果证明,林业分权管理应当始于与当地民众一起工作,建立和完善他们已有的机制;具有代表性和负责任的地方政府将成为这一过程最适合的对话者。 | Anne M.Larson 宰步龙(译) | 2008 | 林业经济2008,,2: | 1 |
| 3 | Investigating Multiple Subtypes of Career Indecision through Cluster Analysis显示文摘 | Lisa M.Larson P.Paul Heppner | | 0,,04: | 1 |
| 4 | Prospective evaluation of ^(18)F-FDG positron emission tomography in the preoperative staging of patients with hepatic colorectal metastases显示文摘Background:Despite considerable advances in preoperative imaging,up to one-third of patients operatively explored for hepatic colorectal metastases are unexpectedly found to harbor unresectable intrahepatic or extrahepatic disease.Methods:The current study is a prospective,blinded study comparing utility of[18F]2-fluoro-2-deoxyglucose positron emission tomography(18F-FDG-PET)to computed tomography(CT)and CT arterial portography(CTAP)as preoperative staging.Results:The 125 planned subjects were enrolled.Findings seen on FDG-PET alone changed therapy for 23 of 125 patients(18%).FDG-PET confirmed other radiologic findings in 16 cases(13%),for an overall influence on therapy in 39 cases(31%).FDG-PET was the most sensitive diagnostic imaging test for extrahepatic cancer;it was 80-90%sensitive for extrahepatic cancer and 70-90%specific.For the 28 cases of unresectable disease due to extrahepatic disease,FDG-PET findings solely changed therapies in 16 cases(57%)and influenced therapy in seven other cases(25%).Of the 21 unresectable cases due to extent of intrahepatic disease,FDG-PET did not solely change therapy in any.Overall,FDG-PET had the lowest sensitivity for hepatic sites compared with CT or CTAP.In particular,small(<1 cm)liver tumors were particularly poorly detected by FDG-PET.The area under the receiver operating characteristic(ROC)curve for small tumors was 0.58 and for patients on chemotherapy it was 0.66,a modest improvement over no imaging.Conclusions:FDG-PET is an important test for preoperative staging of patients with hepatic colorectal metastases,affecting treatment decisions in nearly one-third of patients.The high yield is due mainly to detection of extrahepatic disease.It is therefore recommended in patients with extrahepatic lesions suspected to be disseminated cancer or those with high risk for extrahepatic disease.It is not a good test for identification of small tumors in the liver. | Tim Akhurst Mithat Gönen Raymond E.Baser Lawrence H.Schwartz Scott Tuorto Lynn A.Brody Anne Covey Karen T.Brown Steven M.Larson Yuman Fong | 2022 | Hepatobiliary Surgery and Nutrition2022,11,4: | 1 |
| 5 | 林业部门的民主分权:非洲、亚洲和拉丁美洲的经验教训(续)显示文摘总结了约20个发展中国家林业部门分权管理的研究结果,并通过对在森林治理中起到主要作用的机构和参与者的分析,探讨了成功和失败的范例和主要的因素。研究表明,执行民主分权的案例并不多见,表现在:真正的决策权力、森林资源及其效益仍然是集权管理、选择处理的当地参与者往往不具有代表性或不负责任。现行政策有时伤害了当地的穷人。强调了伞国性的对话和对公民社会特别是边缘群体的授权的重要性。研究结果证明,林业分权管理应当始于与当地民众一起工作,建立和完善他们已有的机制;具有代表性和负责任的地方政府将成为这一过程最适合的对话者。 | Anne M.Larson(著) 宰步龙(译) | 2008 | 林业经济2008,,3: | 1 |
| 6 | 利用全球定位系统(GPS)确定澳大利亚、太平洋及南极洲板块间的相对运动显示文摘为了确定板块运动的速度,我们在位于澳大利亚、太平洋及南极洲三大板块的七个测站上实施了近三年的GPS测量。用这一方法得出的板块运动速度与板块模拟预测和其它空间大地测量得出的结果相同。到目前为止,我们还没发现澳大利亚板块内部变形的证据。位于澳大利亚板块与太平洋板块边界带的新西兰首都惠灵顿相对于澳大利亚板块每年向南西西方向移动20±5mm。该速度介于对这两个板块所预测的速度之间。澳大利亚-南极洲板块和太平洋-南极洲板块的相对欧拉向量值与NUVEL-IA模型的预测值相同,并位于一个标准偏差范围内。 | Kristine M.Larson 曲赞 | 1995 | 地质科学译丛1995,12,4: | 0 |
| 7 | ULTRASHORT PULSE MULTISPECTRAL NON-LINEAR OPTICAL MICROSCOPY显示文摘Ultrashort pulse,multispectral non-linear optical microscopy(NLOM)is developed and used to image,simultaneously,a mixed population of cells expressing different fluorescent protein mutants in a 3D tissue model of angiogenesis.Broadband,sub-10-fs pulses are used to excite multiple fluorescent proteins and generate second harmonic in collagen.A 16-channel multispectral detector is used to delineate the multiple non-linear optical signals,pixel by pixel,in NLOM.The ability to image multiple fluorescent protein mutants and collagen,enables serial measurements of cell-cell and cell-matrix interactions in our 3D tissue model and characterization of fundamental processes in angiogenic morphogenesis. | ADAM M.LARSON ANTHONY LEE PO-FENG LEE KAYLA J.BAYLESS ALVIN T.YEH | 2009 | Journal of Innovative Optical Health Sciences2009,2,1: | 0 |
| 8 | 预靶向:放射免疫治疗的进阶之路显示文摘预靶向放射免疫诊断(PRID)和预靶向放射免疫治疗(PRIT)旨在利用药用放射性核素有效标记抗肿瘤靶向抗体而分别应用于提高肿瘤显像的对比度和肿瘤治疗指数(TI)。与传统的放射性免疫偶联物不同,预靶向策略将肿瘤靶向步骤与有效载荷步骤分开,在减少正常组织暴露的同时提高了肿瘤的摄取量。预靶向策略的关键参数除了对比度和TI外,还包括抗体的免疫原性和特异性、放射性核素的适用性以及在临床中使用的便利性。预靶向的每个步骤都可以单独优化,且作为模块化系统,预靶向策略可广泛地应用于不同的肿瘤靶点、肿瘤类型或放射性核素。然而,尽管预靶向的多功能性为肿瘤的诊疗提供了巨大的应用潜能,但其过程复杂,在临床转化及如何在患者体内达到最佳使用效果方面面临着较大的挑战。该文旨在简要回顾预靶向策略的起源和发展过程,重点阐述目前已被广泛研究的2种蛋白质递送系统(生物素-链霉亲和素及半抗原-双特异性单克隆抗体)、放射性半抗原和放射性核素。此外,该文还将重点阐述预靶向研究领域的创新成果,包括使用生物正交化学和新型蛋白质载体(如自组装-解组装蛋白质和亲和体分子)进行的预靶向。该文并不是对过去30年PRID和PRIT全面的回顾,而是突出阐述了预靶向发展过程中的里程碑成果,并从TI和毒性方面评价其在临床前模型和临床试验中的应用。相信预靶向策略能够帮助人们认识肿瘤临床诊疗一体化实施的障碍,重新激发人们对放射免疫疗法的兴趣,并指导预靶向研究的进一步发展。 | 葛雨秋(译) 付海田(译) 郁春景(审校) Sarah M.Cheal Sebastian K.Chung Brett A.Vaughn Nai-Kong V.Cheung Steven M.Larson | 2022 | 中华核医学与分子影像杂志2022,42,12: | 0 |