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| 1 | 青海互助丰台卡约文化遗址孢粉分析与人类活动研究——化石和现代表土花粉分析结果显示文摘采用相差分析方法,区分出禾本科植物中的农作物花粉;通过对青海互助丰台卡约文化遗址文化层和丰台村周围现代表土样品的孢粉分析,发现孢粉组合中有农作物花粉,反映人类农耕活动对聚落及其周围孢粉组合有明显的影响;文化层样品的孢粉组合显示,卡约文化早期阶段,禾本科植物花粉明显多于晚期阶段,可能反映了卡约文化时期(约公元前1200-800年)农业在社会经济中地位逐步下降的过程;孢粉组合还显示,与现代丰台村相比,卡约文化时期,聚落周围有更多的禾本科植物生长,人类可利用的植物资源比现代丰富。研究结果将有助于综合研究西北地区青铜时代环境与人类文化的关系。 | 靳桂云 王巍 M.Wagner P.E.Tarasov | 2006 | 华夏考古2006，，3： | 10 |
| 2 | Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery显示文摘Therapeutic proteins and peptides have revolutionized treatment for a number of diseases, and the expected increase in macromolecule-based therapies brings a new set of challenges for the pharmaceutics field. Due to their poor stability, large molecular weight, and poor transport properties,therapeutic proteins and peptides are predominantly limited to parenteral administration. The short serum half-lives typically require frequent injections to maintain an effective dose, and patient compliance is a growing issue as therapeutic protein treatments become more widely available. A number of studies have underscored the relationship of subcutaneous injections with patient non-adherence, estimating that over half of insulin-dependent adults intentionally skip injections. The development of oral formulations has the potential to address some issues associated with non-adherence including the interference with daily activities, embarrassment, and injection pain. Oral delivery can also help to eliminate the adverse effects and scar tissue buildup associated with repeated injections. However, there are several major challenges associated with oral delivery of proteins and peptides, such as the instability in the gastrointestinal(GI)tract, low permeability, and a narrow absorption window in the intestine. This review provides a detailed overview of the oral delivery route and associated challenges. Recent advances in formulation and drugdelivery technologies to enhance bioavailability are discussed, including the co-administration of compounds to alter conditions in the GI tract, the modification of the macromolecule physicochemical properties, and the use of improved targeted and controlled release carriers. | Angela M.Wagner Margaret P.Gran Nicholas A.Peppas | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 8 |
| 3 | 利用磁敏感加权成像鉴别成骨性和溶骨性脊柱转移瘤显示文摘目的磁敏感加权MRI对区分脊柱转移瘤是以成骨细胞和溶骨细胞为主的应用评估。材料与方法在本次前瞻性研究中,临床上怀疑有脊柱转移的53例受试者参与了本研究[年龄22~88岁,平均(54.5±14.3)岁;男27例,年龄22~72岁,平均(55.3±12.7)岁。 | S.M.Boker L.C.Adams Y.Y.Bender U.L.Fahlenkamp M.Wagner B.Hamm 文风(译) 王玉婷(校) | 2019 | 国际医学放射学杂志2019，0，2： | 3 |
| 4 | Extracorporeal membrane oxygenation for acute respiratory distress syndrome in burn patients:a case series and literature update显示文摘Background:Acute respiratory distress syndrome(ARDS)has a reported incidence of 34–43%in ventilated burn patients and is associated with a mortality of 59%in the severe form.The use and experience with extracorporeal membrane oxygenation(ECMO)in burn patients developing ARDS are still limited.We present our results and discuss the significance of ECMO in treating burn patients.Methods:A retrospective analysis of burn patients treated with ECMO for ARDS between January 2017 and January 2019 was performed.Demographic,clinical,and outcome data were collected and analyzed.Results:Eight burn patients were treated at our institution with ECMO in the designated time period.Of these,all but one patient had inhalation injury,burn percentage of TBSA was 37±23%,ABSI score was 8.4±2,and R-Bauxscore was 98±21.Seven patients developed severe ARDS and one patient moderate ARDS according to the Berlin classification with a PaO_(2)/FiO_(2) ratio upon initiation of ECMO therapy of 62±22 mmHg.ECMO duration was 388±283 h.Three patients died from severe sepsis while five patients survived to hospital discharge.Conclusions:ECMO is a viable therapy option in burn patients developing severe ARDS and can contribute to survival rates similar to ECMO therapy in non-burn-associated severe ARDS.Consequently,patients with severe respiratory insufficiency with unsuccessful conventional treatment and suspected worsening should be transferred to burn units with the possibility of ECMO treatment to improve outcome. | Mehran Dadras Johannes M.Wagner Christoph Wallner Julika Huber Dirk Buchwald Justus Strauch Kamran Harati Nicolai Kapalschinski Björn Behr Marcus Lehnhardt | 2019 | Burns & Trauma2019，7，1： | 2 |
| 5 | Dynamic Behavior of CO2 Spot Prices显示文摘 | Seifert J M.U brig-Homburg M.Wagner | | 0，，： | 1 |
| 6 | 焊接结构零件的疲劳强度——焊有侧板的平板零件结构应力设计方案显示文摘借助结构应力设计方案预估焊接零件寿命时 ,采用一种比较简单的有限元计算方法确定起决定作用的应力。在计算实践中恰好证明了这种方法的优点。然而为编制有限元网格一定要确立明确的方针。在这方面 ,供研究的设计结构至关重要。为此还介绍了另一种编制有限元网格的方法。为了进行比较 ,研究了按照Radaj的缺口应力集中方法的结果。疲劳强度实验有助于检验计算结果。 | M.Wagner 丁培番 陈巍 | 2000 | 工程设计学报2000，7，1： | 0 |
| 7 | No evidence for enzootic plague within black-tailed prairie dog(Cynomys ludovicianus)populations显示文摘Yersinia pestis,causative agent of plague,occurs throughout the western United States in rodent populations and periodically causes epizootics in susceptible species,including black-tailed prairie dogs(Cynomys ludovicianus).How Y.pestis persists long-term in the environment between these epizootics is poorly understood but multiple mechanisms have been proposed,including,among others,a separate enzootic transmission cycle that maintains Y.pestis without involvement of epizootic hosts and persistence of Y.pestis within epizootic host populations without causing high mortality within those populations.We live-trapped and collected fleas from black-tailed prairie dogs and other mammal species from sites with and without black-tailed prairie dogs in 2004 and 2005 and tested all fleas for presence of Y.pestis.Y.pestis was not detected in 2126 fleas collected in 2004 but was detected in 294 fleas collected from multiple sites in 2005,before and during a widespread epizootic that drastically reduced black-tailed prairie dog populations in the affected colonies.Temporal and spatial patterns of Y.pestis occurrence in fleas and genotyping of Y.pestis present in some infected fleas suggest Y.pestis was introduced multiple times from sources outside the study area and once introduced,was dispersed between several sites.We conclude Y.pestis likely was not present in these black-tailed prairie dog colonies prior to epizootic activity in these colonies.Although we did not identify likely enzootic hosts,we found evidence that deer mice(Peromyscus maniculatus)may serve as bridging hosts for Y.pestis between unknown enzootic hosts and black-tailed prairie dogs. | Rebecca E.COLMAN R.Jory BRINKERHOFF Joseph D.BUSCH Chris RAY Adina DOYLE Jason W.SAHL Paul KEIM Sharon K.COLLINGE David M.WAGNER | 2021 | Integrative Zoology2021，16，6： | 0 |
| 8 | 环境对坦桑尼亚类珊瑚虫分布的影响显示文摘本文研究了有关坦桑尼亚珊瑚礁环境不同方面的类珊瑚虫(刺胞动物门,珊瑚虫纲)的分布和丰度。通过设线截距横切和点取标技术,调查了受到人类不同骚扰程度的5种礁。下列的礁石内,不同栖息地中的类珊瑚虫的生长和其底质的构成:礁坪内部和中部,礁脊,礁坡上2m和4m处,类珊瑚虫存在所有的礁上,并认定了5个种类:Rhodactisrhodostoma,R.mussoides,Ricordea yuma,Actinodiscus Unguja和A.nummiforme,而在所有地方,R.rhodostoma占有优势。在礁内浅水的栖息地里,R.rhodostoma具有极高的密度。R.rhodostoma存在于所有的栖息地,而其他的类珊瑚虫并不是均匀的分布的。在现存生物覆盖物里,类珊瑚虫所占百分比在石珊瑚之后名列第二。本文研究的结果表明,跟其他固着生物相比,类珊瑚虫得益于骚扰,他们喜欢栖息在有死礁、岩石和碎屑的地区而避开浮珊瑚。类珊瑚虫的分布率与水的混乱程度有着相关关系,这些类珊瑚虫在受扰动较大的礁区占优势,即受到营养物和渔业影响的礁区。 | Christopher A.Muhando Baraka L.Kuguru Gregory M.Wagner Nsajigwa E.Mbije Marcus C.hman 曹英志 | 2002 | AMBIO-人类环境杂志2002，31，7： | 0 |
| 9 | 桑给巴尔岛附近硬珊瑚的分布和丰度模式显示文摘东非珊瑚礁的特点是它位于一个离散的动物地理学分区[1],具有经由赤道流接纳和重新分配偏远的种属物质的潜在重要性[2].尽管如此,该地区仍然是世界上研究最少的地区之一.例如,在坦桑尼亚,尽管珊瑚礁是众多的人赖以为生的重要自然资源,却没有受到应有的重视和研究[3~5].为数不多的研究定量分析过坦桑尼亚的珊瑚礁结构[6~13],而且大部分只是限于对一些礁砰进行基线研究. | 林宝法 Nsajigwa E.Mbije Gregory M.Wagner Julius Francis Marcus C.hman Kajsa Garpe | 2002 | AMBIO-人类环境杂志2002，31，7： | 0 |
| 10 | ^(238)U裂变样品质量的比对显示文摘中国原子能科学研究院的2片^(238)U样品和维也纳镭研究和核物理研究所(以下简写IRK)标准^(238)U作品质量之间的比对在联邦德国技术物理研究所(以下简写PTB)、IRK和中国原子能科学研究院(以下简写CIAE)完成。采用了4种方法进行对比:(1)快中子裂变数比的测量;(2)2πα流气式正比计数器α活度的绝对测量;(3)多丝流气式正比计数器α活度的绝对测量;(4)小立体角α计数器α活度的绝对测量。CIAE的2片^(238)U样品质量经刻度分别为:860.25±6.02μg和913.96±6.40μg。 | 李景文 卢涵林 容超凡 赵文荣 于伟翔 程江涛 W.Mannhart M.Wagner H.Vonach | 1993 | 原子能科学技术1993，27，6： | 0 |
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