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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 奈必洛尔和缬沙坦固定剂量联合治疗高血压的疗效与安全性研究显示文摘任意2类降压药物固定剂量联合降压作用强于单独增加一类药物剂量的作用。该研究评估β受体阻滞剂奈必洛尔(nebivolol)和血管紧张素受体拮抗剂缬沙坦(valsartan)固定剂量联合治疗成人高血压的疗效与安全性。方法:研究人员在美国401个医疗中心进行了为期8周、临床试验3期、多中心、随机、双盲、安慰剂平行对照试验。参与者均为≥18岁的高血压患者(但血压≤180/110mm Hg,1mm Hg=0.133kPa),以15例为一治疗组, | 刘莉 叶鹏 Giles TD Weber MA Basile J Gradman AH Bharucha DB Chen W Pattathil M | 2014 | 中华高血压杂志2014，22，8： | 2 |
| 3 | Stretch induces cytokine release by alveolar epithelial cells in vitro显示文摘 | Vlahakis NE Sehroeder MA Limper AH | 1999 | Am J Physiol1999，277，1： | 1 |
| 4 | Effect of carvedilol on portal pressure estimated by hepatic vein Doppler ultrasound waveform and damping index in cirrhotic patients显示文摘 | Hussain Q Badruddin AH Chaudhry MA | 2010 | J Coil Physicians Surg Pak2010，20，9： | 1 |
| 5 | Pregnant mothers with resolved anxiety disorders and their offspring have reduced heart rate variability:implications for the health of children显示文摘 | Braeken MA Kemp AH Outhred T | 2013 | PLoS One2013，8，83： | 1 |
| 6 | Expression of connexins 36,43, and 45 during postnatal development of the mouse retina显示文摘 | Kiahara AH Mantovani de Castro L Belmonte MA Yan CY Moriscot AS Hamassald DE | 2006 | J Neurobiol2006，66，13： | 1 |
| 7 | The effects of mela-tonin premedication on propofol and thiopental induction dose-re-sponse curves: a pospective, randomized, double blind study显示文摘 | Naguib M Samarkandi AH Moniem MA | 2006 | Anesth Analg2006，103，： | 1 |
| 8 | Hepatitis B transmission from contaminated cryopreservation tank显示文摘 | Tedder RS Zuckerman MA Goldstone AH | 1995 | Lancet1995，346，8968： | 1 |
| 9 | PURLs: Should you screen for postpartum depression? 显示文摘 | Slattengren AH Prasad S Kaiseruddin MA | 2013 | J Faro Pract2013，62，11： | 1 |
| 10 | Morphine versus midazolam as upfront therapy to control dyspnea perception in cancer patients while its underlying cause is sought or treated 显示文摘 | Navigante AH Castro MA Cerchietti LC | 2010 | J Pain Symptom Manage2010，39，5： | 1 |
| 11 | Anal sphincter disruption during vaginal delivery 显示文摘 | Sultan AH Kamm MA Hudson CN | 1993 | New England Journal of Medicine1993，329，： | 1 |
| 12 | MiR-125b promotes growth of prostate cancer xenograft tumor through targeting pro-apoptotic genes 显示文摘 | Shi XB Xue L Ma AH | 2011 | Prostate2011，71，： | 1 |
| 13 | Epigenetics in systemic lupus erythematosus: leading the way for specific therapeutic agents显示文摘 | JEFFRIES MA SAWALHA AH | 2011 | Int J Clin Rheumtol2011，6，4： | 1 |
| 14 | Laparoscopic cholecystectomy in cirrhotics: a prospective randomized study comparing the conventional diathermy and the harmonic scalpel for gallbladder dissection显示文摘 | Bessa SS Abdel-Razek AH Sharaan MA | 2011 | J Laparoendosc Adv Surg Tech A2011，21，1： | 1 |
| 15 | Expression of connexins 36, 43, and 45 during postnatal development of the mouse retina显示文摘 | Kihara AH Mantovani de Castro L Belmonte MA | 2006 | J Neurobiol2006，66，13： | 1 |
| 16 | Functional analysis of 44 mutant androgen receptors from human prostate cancer显示文摘 | Shi XB Ma AH Xia L | 2002 | Cancer Res2002，62，： | 1 |
| 17 | Assessment of biological changes of continuous whole body exposure to static magnetic field and extremely low frequency electromagnetic fields in mice 显示文摘 | Hashish AH El-Missiry MA Abdelkader HI | 2008 | Ecotoxicology and Environmental Safety2008，71，3： | 1 |
| 18 | Early meta-bolic programming of puberty onset:impact of changes inpostnatal feeding and rearing conditions on the timing ofpuberty and development of the hypothalamic kisspeptinsystem显示文摘 | Castellano JM Bentsen AH Sánchez-Garrido MA Ruiz-Pino F Romero M Garcia-Galiano D | 2011 | Endocrinology2011，152，9： | 1 |
| 19 | Laparoscopic cholecys-tectomy in cirrhotics:a prospective randomized study comparing the conventional diathermy and the harmonic scalpel for gallbladder dis-section显示文摘 | Bessa SS Abdel-Razek AH Sharaan MA | | 0，，： | 1 |
| 20 | Highly reactive multilayer-assembled TiO2 coating on electrospun polymer nanofibers显示文摘 | Jung Ah Lee Kevin C Krogman Ma Minglin | 2009 | Adv Mater2009，21，12： | 1 |
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