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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | An improved technique for the in situ detection of DNA after polymerase chain reaction application显示文摘 | NUOVO G J GALLERY F MAC C P | 1991 | American Journal of Pathology1991，139，： | 1 |
| 3 | Interleukin-21:A critical regulator of the balance between effector and regulatory T-cell responses显示文摘 | Monteleone G Pallone F Mac Donald TT | 2008 | Trends Immunol2008，29，6： | 1 |
| 4 | Poly- aniline: A new concept in conducting polymers 显示文摘 | MAC DIARMID A G CHIANG J C RICHTER A F | 1987 | Synth Met1987，18，13： | 1 |
| 5 | Thermal residual stress of polycrystalline diamond compacts显示文摘 | CHEN F XU G MAC D | | 0，，02： | 1 |
| 6 | Timber investment returns for selected plantations and native forests in South America and the Southern United States 显示文摘 | Cubbage F Mac Donagh P Júnior JS Rubilar R Donoso P Ferreira A Hoeflich VV Olmos M Ferreira G Balmelli G Siry J Báez MN Alvarez J | 2006 | New For2006，33，： | 1 |
| 7 | An electromyographic study ofthe tongue during vowel production显示文摘 | Mac Neilage P F Sholes G N | 1964 | Journal of Speech Language and Hearing Research1964，7，3： | 1 |
| 8 | Statistical process control of multivariate process显示文摘 | MAC G J F KOURTI T | 1995 | Control Engineering Practice1995，3，： | 1 |
| 9 | Kallmann's syndrome:molecular pathogenesis显示文摘 | Hu Y Tanriverdi F Mac Coll G S | 2003 | Int J Biochem Cell Biol2003，35，8： | 1 |
| 10 | Experimental hybridization between the smooth flounder (Liopsetta putnami) and winter flounder (Pseudopleuronectes americanus) 显示文摘 | HOOMBEEK F K MAC PHEE G K MOROZ L | 1984 | Genetics1984，107，3： | 1 |
| 11 | Long-term therapy with sulphasalazine protects against colorectal cancer in ulcerative colitis: a retrospective study of colorectal cancer risk and compliance with treatment in Leicestershire显示文摘 | G A Moody V Jayanthi C S J Probert H Mac Kay J F Mayberry | 1996 | European Journal of Gastroenterology & Hepatology1996，，12： | 1 |
| 12 | Effect of moisture condition on concrete core strengths 显示文摘 | BARTLETT F M MAC GREGOR J G | 1994 | ACI Materials Journal1994，91，3： | 1 |
| 13 | Where is VEGF in the body? A meta-analysis of VEGF distrbution in cancer显示文摘 | KUT C MAC G F POPEL A S | 2007 | Br J Cancer2007，97，7： | 1 |
| 14 | Experimental hybridization between the smooth flounder ( Liopsetta putnami) and winter flounder ( Pseudopleuronectes americanus) 显示文摘 | Hoombeek F K Mac Phee G K Moroz L | 1984 | Genetics1984，107，3： | 1 |
| 15 | deleterious effects of salt intake other then effects on blood pressure 显示文摘 | Antonios T F Mac Gregor G A | 1995 | Clin Exp Pharmacol Physiol1995，22，： | 1 |
| 16 | Studies on the decontamination of of air by plants显示文摘 | CORNEJO J J MUNOZ F G MAC Y | 1999 | Ecotoxicology1999，8，4： | 1 |
| 17 | Landscape classification and problem specific reasoning for genetic algorithms 显示文摘 | MAC F BHRIDE G McGINNITV T M | 2005 | Krbernetes2005，34，910： | 1 |
| 18 | Allelopathy - a natural alternative for weed control显示文摘 | MACíAS F A MOLINILLO J M G VARELA R M | 2007 | Pest Management Science2007，63，4： | 1 |
| 19 | Prognostic significance of Ki-67 and topoisomerase 2 alpha expression in infiltrating ductal carcinoma of the breast:a multivariate analysis of 863 cases显示文摘 | Rudolph P Mac Grogan G Bonichon F | 1999 | Breast Cancer Res Treat1999，55，： | 1 |
| 20 | Antiproliferative effects on keratinocytes of a range of clinically used drugs with calmodulin antagonist activity显示文摘 | MAC N S DAWSON R A CROCKER G TUCKER W F BITTINER B SINGLETON J G HUNTER T TIERNEY D F | 1993 | Br J Dermatol1993，128，2： | 1 |
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