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| 1 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 2 | Strategic management of technical functions 显示文摘 | Adler P S McDonald D W MacDonald F | 1992 | Sloan Management Review1992，33，2： | 1 |
| 3 | Marked redution of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhage 显示文摘 | Klimo P Kestle JR MacDonald J D | 2004 | J Neurosurgery2004，100，2： | 1 |
| 4 | Baseline predic, tors of tolerability to carvedilol in patients with chronic heart failure显示文摘 | KRUM H NINIO D MacDONALD P | 2000 | Heart2000，849，6： | 1 |
| 5 | pH Measurements of High Temperature Aqueous Environments with Stabilized-Zirconia Membranes 显示文摘 | Hettiarachchi S Kedzierzawski P Macdonald D D | 1985 | J Electrochem Soc1985，132，8： | 1 |
| 6 | Outbreak of Listeriosis among Mexican immigrants as a result of consumption of illicitly produced Mexican-style cheese显示文摘 | MACDONALD P D WHITWAM R E BOGGS J D | 2005 | Clin Infect Dis2005，40，5： | 1 |
| 7 | Banding of u- rea increased ammonia volatilization in a dry acidic soil显示文摘 | ROCHETTE P MACDONALD J D ANGERS D A | 2009 | Journal of Environ- mental Quality2009，38，： | 1 |
| 8 | Unused fertilizer nitrogen in arable soils-its contribution to nitrate leaching显示文摘 | Macdonald A J Powlson D S Poulton P R | 1989 | J of Sci Food Agric1989，46，： | 1 |
| 9 | A review ofworldwide contamination of cereal grains and animal feed withFusarium mycotoxins显示文摘 | Placinta C M D' Mello J P F Macdonald A M C | 1999 | Animal Feed Science and Technology1999，78，12： | 1 |
| 10 | The utility of PBPK in the safety assessment of chloroform and carbon tetrachloride显示文摘 | DELIC J I LILLY P D MACdONALD A J | 2000 | Regulatory Toxicology and Pharmacology2000，32，2： | 1 |
| 11 | External Reference Electrodes for Use in High-Temperature Aqueous Systems 显示文摘 | Macdonald D D Scott A C Wentrcek P | 1979 | J Electrochem Soc1979，126，6： | 1 |
| 12 | Associations among body condition score, body weight, somatic cell count, and clinical mastiffs in seasonally calving dairy cattle显示文摘 | Berry D P Lee J M Macdonald K A | 2007 | Journal of dairy science2007，90，： | 1 |
| 13 | Effects of suspended sediments on aquatic ecosystems 显示文摘 | Newcombe C P MacDonald D D | 1991 | Nor Am J Fish Manag1991，11，： | 1 |
| 14 | A review of worldwide contamination of cereal grains and animal feed with Fusariummycotoxins显示文摘 | Placinta C M D\'Mello J P F Macdonald A M C | 1999 | Animal Feed Science & Technology1999，78，1： | 1 |
| 15 | Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease显示文摘AIM To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on wholebody and hepatic fat oxidation of patients with nonalcoholic fatty liver disease(NAFLD).METHODS Participants were randomised into either circuit exercise training(EX;n = 13;3 h/wk without changes in dietary habits),or dietary energy restriction(ER) without changes in structured physical activity(ER;n = 8).Respiratory quotient(RQ) and whole-body fat oxidation rates(Fatox) were determined by indirect calorimetry under basal,insulin-stimulated and exercise conditions.Severity of disease and steatosis was determined by liver histology;hepatic Fatox was estimated from plasma β-hydroxybutyrate co.ncentrations;cardiorespiratory fitness was expressed as VO2 peak.Complete-case analysis was performed(EX:n = 10;ER:n = 6).RESULTS Hepatic steatosis and NAFLD activity score decreased with ER but not with EX.β-hydroxybutyrate concentrations increased significantly in response to ER(0.08 ± 0.02 mmol/L vs 0.12 ± 0.04 mmol/L,P = 0.03) but remained unchanged in response to EX(0.10 ± 0.03 mmol/L vs 0.11 ± 0.07 mmol/L,P = 0.39).Basal RQ decreased(P = 0.05) in response.to EX,while this change was not significant after ER(P = 0.38).VO_(2peak)(P < 0.001) and maximal Fa_(tox) during aerobic exercise(P = 0.03) improved with EX but not with ER(P > 0.05).The increase in β-hydroxybutyrate concentrations was correlated with the reduction in hepatic steatosis(r =-0.56,P = 0.04).CONCLUSION ER and EX lead to specific benefits on fat metabolism of patients with NAFLD.Increased hepatic Fat_(ox) in response to ER could be one mechanism through which the ER group achieved reduction in steatosis. | Ilaria Croci Nuala M Byrne Veronique S Chachay Andrew P Hills Andrew D Clouston Trisha M O'Moore-Sullivan Johannes B Prins Graeme A Macdonald Ingrid J Hickman | 2016 | World Journal of Hepatology2016，8，27： | 1 |
| 16 | A review of worldwide contamination of cereal grains and animal feed with Fusarium mycotoxins显示文摘 | PLACINTA C M MELLO J P F D MACDONALD A M C | 1999 | Animal Feed Science and Technology1999，78，12： | 1 |
| 17 | The medial approach for Arthroscopic assisted fixation of lateral tibial plateau fractures: patient selection and mid-to-long term results 显示文摘 | Levyb A Herrera D A Macdonald P | 2008 | Orthop Trauma2008，22，3： | 1 |
| 18 | Word knowledge and vocabulary instruction显示文摘 | MACDONALD P | 2001 | International Conference on Engineering Education2001，，8： | 1 |
| 19 | A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer显示文摘 | HU X MACDONALD D M HUETTNER P C | 2009 | Gynecol Oncol2009，114，3： | 1 |
| 20 | Associations among body condition score,body weight,somatic cell count,and clinical mastitis in seasonally calving dairy cattle显示文摘 | BERRY D P LEE J M MACDONALD K A | 2007 | Journal of Dairy Science2007，90，2： | 1 |
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