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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | 膨胀岩石室内试验ISRM建议方法草案显示文摘 | Madsen F T 刘元高 | 2002 | 岩石力学与工程学报2002，21，4： | 5 |
| 3 | The interaction between water movement,sediment dynamics and submersed macrophyte显示文摘 | MADSEN J D CHAMBERS P A JAMES W F | 2001 | Hydrobiologia2001，，444： | 1 |
| 4 | Cyclone induced storm surge and flood forecasting in the northern bay of Bengal 显示文摘 | MADSEN H JAKOBSEN F | 2004 | Coastal Engineering2004，51，4： | 1 |
| 5 | Papillary glioneuro-nal tumor--a new tumor entity 显示文摘 | Broholm H Madsen F F Wagner A A | 2002 | Clin Neuropathol2002，21，1： | 1 |
| 6 | Tranexamic acid given intraop- eratively reduces blood loss after total knee replacement : a randomized controlled study 显示文摘 | Veien M Sorensen JV Madsen F et cd | 2002 | Acta Anaesthesiol Scan2002，46，： | 1 |
| 7 | Functional domain analysis of the Remorin protein LjSYMREM1in Lotus japonicus显示文摘 | Tóth K Stratil T F Madsen E B | 2012 | PLoS One2012，7，30： | 1 |
| 8 | Comparison of annual maximum series and partial duration series methods for modeling extreme hydrological events, 1, At-site modeling显示文摘 | Madsen H Rasmussen P F Rosbjerg D | 1997 | Water Resources Research1997，33，4： | 1 |
| 9 | Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein显示文摘 | Larsen F Madsen HO Sim RB | 2004 | J Biol Chem2004，279，21： | 1 |
| 10 | Therapeutic effect of turquoise versus blue light with equal irradiance in preterm infants with jaundice显示文摘 | Ebbesen F Madsen P Stφrings | 2007 | Acta Paediatr2007，96，6： | 1 |
| 11 | On the transformation of struvite into newberyite in aqueous systems 显示文摘 | Boistelle R Abbona F Madsen H E | 1983 | Phys Chem Miner1983，9，5： | 1 |
| 12 | Effect of oral nitroglycerin and cold stress on myocardial perfusion in areas subtended by stenosed and nonstenosed coronary arteries显示文摘 | BOTTCHER M MADSEN M M RANDSBAEK F | 2002 | Am J Cardiol2002，89，： | 1 |
| 13 | Hemiarthroplasty or internal fixation for intracapsular displaced femoral neck fractures:randomised controlled trial显示文摘 | Frihagen F Nordsletten L Madsen JE | 2007 | BMJ2007，335，7632： | 1 |
| 14 | Mannose-bingding lectin deficiency-Revised 显示文摘 | Garred P Larsen F Madsen HO | 2003 | Mol Immunol2003，40，24： | 1 |
| 15 | Hemiarthroplasty or internal fixation for intracapsular displaced femoral neck fractures:randomized controlled trial显示文摘 | Frihagen F Nordsletten L Madsen JE | 2007 | BMJ2007，335，7632： | 1 |
| 16 | Tranexamic acid given intraoperatively reduces blood loss after total knee replacement:a randomized, controlled study显示文摘 | Veien M Sorensen JV Madsen F | 2002 | Acta Anaesthesiol Scand2002，46，10： | 1 |
| 17 | Garden 's classification of femoral neck fractures:an assessment of interobserver variation显示文摘 | Frandsen PA Andersen E Madsen F | 1998 | J Bone Joint Surg Br1998，70，： | 1 |
| 18 | The interaction between water movement,sediment dynamics and sub- mersed macrophytes显示文摘 | Madsen J D Chambers P A James W F | 2001 | Hydrobiologia2001，444，123： | 1 |
| 19 | Complexation graft copolymer networks:swelling properties, calcium binding and proteolytic enzyme inhibition 显示文摘 | Madsen F Peppas N A | 1999 | Biomaterials1999，20，18： | 1 |
| 20 | Development of pectin matrix tablets for colonic delivery of model drug ropivacaine显示文摘 | Ahrabi S F Madsen G Dyrstad K | 2000 | Eur J Pharm Sci2000，10，1： | 1 |
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