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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Pentoxifylline treatment and penile calcifications in men Nith Peyronie's disease显示文摘 | James F Smith Alan W Shindel Yun-Ching Huang Raul I Clavijo Lawrence Flechner Benjamin N Breyer Michael L Eisenberg Tom F Lue | 2011 | Asian Journal of Andrology2011，13，2： | 2 |
| 3 | The interaction between water movement,sediment dynamics and submersed macrophyte显示文摘 | MADSEN J D CHAMBERS P A JAMES W F | 2001 | Hydrobiologia2001，，444： | 1 |
| 4 | Comprehensive, quantitative, congener-specific analysis of eight aroclors and complete PCB congener assignments 显示文摘 | George M F Robert E W James C C | 1996 | Chernosphere1996，33，： | 1 |
| 5 | The permeability of fibrous porous media显示文摘 | JACKSON W G JAMES F D | 1986 | The Canadian Journal of Chemical Engineering1986，64，3： | 1 |
| 6 | Esthesioneuroblastoma:Continued Follow-up of a single Institution' s Experience 显示文摘 | Andrew H James F Paul W | 2006 | Arch Otolaryngol Head Neck Surg2006，132，： | 1 |
| 7 | Meteor: a constraint-based FIR filter design program显示文摘 | KENNETH S THOMAS W P JAMES F K | 1992 | IEEE Transactions on Signal Processing1992，40，8： | 1 |
| 8 | Therapeutic Choices in Reflux Disease: Defining the criteria for selecting a proton pump inhibitor 显示文摘 | James W F | 2004 | Am J Med2004，117，5： | 1 |
| 9 | Sleep Apnea Following Stroke显示文摘 | Harbison J A James O F W Gibson G J | 2000 | Crebrovase Dis2000，10，2： | 1 |
| 10 | Coaxial electrohydrodynamic spraying of plasmid DNA/polyethylenimine (PEI) polyplexes for enhanced monviral gene delivery显示文摘 | Yun W Zheng F James Lee L | 2010 | Biotechnology and Bioengineering2010，4，105： | 1 |
| 11 | Practice recommendations for preventing heel pressure ulcers显示文摘 | Evonne F Suzy S W James B | 2008 | Ostomy Wound Manage2008，54，10： | 1 |
| 12 | Ground-water modeling: Recent developments显示文摘 | CHARLES R F JAMES W M | 1980 | Groundwater1980，18，6： | 1 |
| 13 | Human capital heterogeneity,collaborative relationships,and publication patterns in a multidisciplinary scientific alliance:a comparative case study of two scientific teams显示文摘 | JOSEPH F P JAMES B W HARALD M F | 2004 | Research Policy2004，，33： | 1 |
| 14 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009，113，： | 1 |
| 15 | Cadmium toxicity among wildlife in the Colorado Rocky Mountaion显示文摘 | James R L Gene E L John W F | | 0，，13： | 1 |
| 16 | Extraintestinal pathogenic Escherichia coli 显示文摘 | James L S Pina M F Nereus W G | 2007 | Foodborne Pathog Dis2007，4，： | 1 |
| 17 | The use of probane in domestic refrigerators显示文摘 | James R W Missenden J F | 1992 | International Journal of Refrigeration1992，15，2： | 1 |
| 18 | Role of transition metal catalysis in the formation of natural gas显示文摘 | Mango F D Hightower J W James A T | 1994 | Nature1994，368，： | 1 |
| 19 | Sediment resuspension and light attenuation in peoria lake: Can macrophytes improve water quality in this shallow system? 显示文摘 | James W F Best E P Barko J W | 2004 | Hydrobiologia2004，515，1： | 1 |
| 20 | Role of transitional-metal catalysis in the formation of natural gas 显示文摘 | Mango F D Hightower J W James A T | 1994 | Nature1994，，368： | 1 |
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