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| 1 | Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats显示文摘AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in rats.METHODS:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were dissected.Colonic mucus content was estimated using Alcian blue dye binding technique.In colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were evaluated.The activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were measured.Concentrations of nucleic acids(DNA and RNA)and total protein were also estimated in colon tissues.Colonic levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were estimated.In cross section of colitis tissue the histopathological changes were observed.RESULTS:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls respectively.Naringenin supplementation,significantly and dose dependently increased the colonic mucus content.The elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0.05;26.74±3.17 nmol/L,P<0.01 nmol/L and 17.74±2.69 nmol/L,P<0.01)compared to AA(59.90±16.34 nmol/L)group while the decreased levels of T-GSH and NP-SH and activities of CAT and SOD found increased by NG treatments in dose dependent manner.The decreased values of nucleic acids and total protein in AA group were also significantly(P<0.01)increased in all three NG supplemented groupsrespectively.NG pretreatment inhibited the TNF-levels(123.76±3.76 pg/mg,122.62±3.41 pg/mg and121.51±2.61 pg/mg vs 134.24±4.78 pg/mg,P<0.05)compared to AA group,respectively.Interleukins,IL-1 and IL-6 levels were also decreased in NG50+AA(314.37±16.31 pg/mg and 292.58±23.68 pg/mg,P<0.05)and NG100+AA(416.72±49.62 pg/mg and 407.96±43.87 pg/mg,P<0.05)when compared to AA(352.46±8.58 pg/mg and 638.58±115.98pg/mg)group.Similar decrease(P<0.05)was seen in PGE2and NO values when compared to AA group.The group pretreated with MES,as a reference drug,showed significant(P<0.01)protection against the changes induced in colon tissue by AA administration respectively.CONCLUSION:In present study,NG produced antioxidant and anti-inflammatory effects demonstrating protective effect in inflammatory bowel disease. | Salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed | 2013 | World Journal of Gastroenterology2013，19，34： | 20 |
| 2 | 澳大利亚初级保健诊所新发腰背痛患者的预后:起始队列研究显示文摘目的估计初级保健诊所内新发腰背痛患者的1年预后,并确定其预后因素。设计1年随访队列研究。地点澳大利亚悉尼的初级保健诊所。参试者初级保健诊所接诊的973例非特异性腰背痛连续患者(平均年龄43.3岁,男性54.8%)。该起始队列患者腰背痛时间不足两周,征集自170名全科医生、理疗师或按摩师诊所。主要评估指标参试者完成基线调查问卷后,分别于初次就诊后6周、3个月和21个月时复查评估。评估内容包括:工作恢复情况、功能恢复情况和疼痛消失情况。潜在预后因素与恢复所需时间的关联性用Cox回归建模分析。结果12个月随访率〉97%。基线时工作能力下降的患者半数在14天内恢复了以前的工作状态(95%可信区间11-17天),83%在3个月内恢复。残疾(中位恢复时间31天,25-37天)和疼痛(中位58天,52-63天)则需要较长的时间才能恢复。只有72%的受试者于基线访问后12个月获得完全康复。高龄、赔偿诉讼、疼痛较重、就诊前腰背痛时间较长、就诊前因疼痛活动减少天数较多、抑郁情绪以及预期危险持续与所需恢复时问较长相关。结论在这个急性腰背痛初级保健患者队列,患者的预后并不像临床指南声称的那样乐观。多数患者的恢复缓慢。近三分之一的患者在腰背痛发作后1年尚未恢复。 | Nicholas Henschke Christopher G Maher Kathryn M Refshauge Robert D Herbert Robert G Cumming Jane Bleasel John York Anurina Das James H McAuley 蓝恭涛(译) | 2008 | 英国医学杂志中文版2008，11，6： | 2 |
| 3 | Static response of sands reinforced with randomly distributed fibers 显示文摘 | Maher M H Gray D H | 1990 | Journal of Geotechnieai Engineering1990，116，11： | 1 |
| 4 | A model for synch-ronous collaborative design using CAD and database management显示文摘 | Maher M L Rutherford J H | 1997 | Research in Engineering Design1997，9，7： | 1 |
| 5 | Mechanical properties of kaolinite/fiber soil composite 显示文摘 | M H Maher Y C HO | 1994 | Journal of Geotechnical Engineering1994，120，8： | 1 |
| 6 | Holocene sediment accumulation rates in the western Loess Plateau, China, and a 2 500-year record of agricultural activity, revealed by OSL dating显示文摘 | Roberts H M Wintle A G Maher B A | 2001 | The Holocene2001，11，： | 1 |
| 7 | The mycotoxin Patulin increases colonic epithelial permeability in vitro显示文摘 | Mohan H M Collins D Maher S | 2012 | Food and Chemical Toxicology2012，50，11： | 1 |
| 8 | Mechanical properties of kaolinite/fiber soil composite 显示文摘 | Maher M H Ho Y C | 1994 | Journal of Geotechnical Engineering1994，，120： | 1 |
| 9 | Adipose tissue stearoylCoA desaturase mRNA is increased by obesity and decreased by polyunsaturated fatty acids显示文摘 | Jones B H Maher M A Banz W J | 1996 | Am J Physiol1996，271，： | 1 |
| 10 | Static response of sand reinforced with randomly distributed fibers 显示文摘 | MAHER M H GRAY D H | 1990 | Journal of Geotechnical Engineering1990，116，8： | 1 |
| 11 | Leaching requirement and salinity threshord for the yield and agronomic characteristic of halophytes under salt stress显示文摘 | El-Sayed H El-Haddad M Noaman Maher | 2001 | Journal of Arid Environments2001，，49： | 1 |
| 12 | Imaging of primary non -Hodgkin' s lyre phoma of the liver显示文摘 | Maher M M McDermott S R Fenlon H M Conroy D O'Keane J C Carney D N | 2001 | Clin Radiol2001，56，： | 1 |
| 13 | Static response of sands reinforced with randomly distributed fibers显示文摘 | Maher M D H Gray | 1990 | Journal of Geotechnical Engineering (ASCE)1990，116，11： | 1 |
| 14 | High performance liquid chromatographic determination of some co-administered anticancer drugs in pharmaceutical preparations and in spiked human plasma 显示文摘 | Fahmy O T Korany M A Maher H M | 2004 | J Pharm Biomed Anal2004，34，5： | 1 |
| 15 | Holocene loess accumulation and soil development at the western edge of the Chinese Loess Plateau:implications for magnetic proxies of palaeorainfall显示文摘 | Maher B A Hu mengyu Roberts H M | 2003 | Quaternary science Reviews2003，22，5167： | 1 |
| 16 | Imaging of primary non-Hodgkin's lymphoma of the liver显示文摘 | Maher M M McDermott S R Fenlon H M | 2001 | Clin Radiol2001，56，4： | 1 |
| 17 | Static response of sands reinforced with randomly distributed fibers显示文摘 | Maher M D H Gray | 1990 | Journal of Geotechnical Engineering (ASCE)1990，116，11： | 1 |
| 18 | High performance liquid chromatographic determination of some coadministered anticancer drugs in pharmaceutical preparations and in spiked human plasma 显示文摘 | Fahmy O T Korany M A Maher H M | 2004 | J Pharm Biomed Anal2004，34，： | 1 |
| 19 | Epidermal growth factor receptor and Ink4a/Arf显示文摘 | Robert M Bachoo Elizabeth A Maher Keith L Ligon Norman E Sharpless Suzanne S Chan Mingjian James You Yi Tang Jessica DeFrances Elizabeth Stover Ralph Weissleder David H Rowitch David N Louis Ronald A DePinho | 2002 | Cancer Cell2002，，3： | 1 |
| 20 | Co-evolution as a computational and cognitive model of design显示文摘 | Maher M L Tang H H | 2003 | Research in Engineering Design2003，14，1： | 1 |
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