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| 1 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 2 | De novo- engineered transcription activator-like effector ( TALE ) hybrid nuclease with novel DNA binding specificity cre- ates double-strand breaks 显示文摘 | Mahfouz M M Li L Shamimuzzaman M | 2011 | Proceedings of the Nation- al Academy of Sciences of the United States of America2011，108，6： | 1 |
| 3 | Hypervascular liver lesions:differentiation of focal nodular hyperplasia from malignant tumors with dynamic gadolinium-enhanced MR imaging 显示文摘 | Mahfouz AE Hamm B Taupitz M | 1993 | Radiology1993，186，1： | 1 |
| 4 | Liver Metastases:Improved Detection with Dynamic Gadolinium-enhanced MR Imaging显示文摘 | Hamm B Mahfouz AE Taupitz M | | Radiology0，202，： | 1 |
| 5 | Associations of frac- tional pulse pressure to aortic stiffness and their impact on diastolic function and coronary flow reserve in asymptomatic diabetie patients with normal coronary angiography 显示文摘 | Mahfouz RA Elawady W Abdu M | 2013 | Cardiol J2013，20，6： | 1 |
| 6 | Investigation of High-Accuracy Indoor 3-D Positioning U- sing UWB Technology 显示文摘 | MAHFOUZ M R ZHANG Ce-min MERKL B C | 2008 | Microwave Theory and Tech- niques2008，56，6： | 1 |
| 7 | Calcification in focal nodular hyperplasias:a new problem for differentiation from fibrolamellar hepatocellular carcinoma显示文摘 | Caseiro-Alves F Zins M Mahfouz AE | 1996 | Radiology1996，198，3： | 1 |
| 8 | Three Models for determining the induction time in the browning kinetics of the Granny Smith apple under static conditions显示文摘 | VEGEL-TURENNE C MAHFOUZ M ALLAF K | 1999 | Journal of Food Engineering1999，41，： | 1 |
| 9 | New high-voltage directional and phase selection protection technique based on real power system data显示文摘 | EISSA M M MAHFOUZ M M A | 2012 | IET Generation Transmission&Distribution2012，6，11： | 1 |
| 10 | Retention of intron -1 in cathelicidin-4 rarna of egyptian nativeand frisia crossbred cattle 显示文摘 | Abou Mossallam A A Mahfouz E R Bibars M A | 2007 | J Appl Sci Res2007，3，11： | 1 |
| 11 | Preanesthetic medication in children : A comparison of intranasaldexmedetomidine versus oral midazolam 显示文摘 | GHALI A M’MAHFOUZ A K AL-BAHHANI M | 2011 | Saudi J An- aesth2011，5，4： | 1 |
| 12 | Gene expression profiling of pediatric acute myelogenous leukemia显示文摘 | Ross ME Mahfouz R Onciu M | 2004 | Blood2004，104，12： | 1 |
| 13 | Preanesthetic medication in children:A comparison of intranasal dexmedetomidine versus oral midazolam显示文摘 | Ghali AM Mahfouz AK Al-bahrani M | 2011 | Saudi J Anaesth2011，5，4： | 1 |
| 14 | Hypervascular liver lesions:differentiation of focal nodular hyperplasia from malignant tumors with dynamic gadolinium-enhanced MR imaging显示文摘 | Mahfouz AE Hamm B Taupitz M | 1993 | Radiology1993，186，1： | 1 |
| 15 | 27- Hydroxycholesterol causes remodeling in endothelial cell membrane lipid composition comparable to remodeling in the failed vein grafts of CABG patients显示文摘 | KUMMEROW F A MAHFOUZ M M ZHOU Q | 2006 | Life Sci2006，78，9： | 1 |
| 16 | Molecular assessment of neck dissections supports preserving level IIB lymph nodes in selective neck dis- section for laryngeal squamous cell carcinoma with a clinically negative neck显示文摘 | ELSHEIKH M N MAHFOUZ M E SALIM E I | 2006 | ORL J Otorhinolaryngol Relat Spec2006，68，： | 1 |
| 17 | Calcification in focal nodular hyperplasia: A new problem for differentiation from fibrolamellar hepatocellular carcinoma 显示文摘 | Caseiro-Alves F Zins M Mahfouz A E | 1996 | Radiology1996，198，3： | 1 |
| 18 | Liver metastases:improved detection with dynamic gadolinium-enhanced MR imaging显示文摘 | Hamm B Mahfouz AE Taupitz M | 1997 | Radiology1997，202，： | 1 |
| 19 | Novel 5-(2-hydroxyphenyl)-3-substituted-2,3-dihydro- 1,3,4-oxadiazole-2-thione derivatives: Promising antieaneer agents显示文摘 | Aboraia A S Abdel-Rahman H M Mahfouz N M | 2006 | Bioorg Med Chem2006，14，： | 1 |
| 20 | Design, synthesis and antiinflammatory activity of some 1,3,4 oxadiazole de rivatives显示文摘 | Omar F A Mahfouz N M Rahman M A | 1996 | Eur J Med Chem1996，31，6： | 1 |
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