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    题名 作者 年代 出处 被引量
1Effects of extract of Ginkgo biloba with venlafaxine on brain injury in a rat model of depression显示文摘Background Recent studies have indicated that chronic stress may give rise to brain damage, which is related to the genesis of depression. The purpose of this study is to investigate the effects of extract of Ginkgo biloba (EGb) and venlafaxine on depression.Methods Rats were treated with chronic and comprehensive stress to create a depression model. Immunohistochemistry was used to detect the expression of brain-derived neurotrophic factor (BDNF) in the hippocampal CA3 neurons of rats treated with different drugs. Behavioral changes of these rats were also examined. Results The expression of BDNF in the hippocampal CA3 neurons of the depression model decreased with a reduction in exploring behavior and a significant increase in fecal production. The expression of neuron nitric-oxide synthase (nNOS) protein also increased in the rats compared to normal controls. The rats treated with EGb and venlafaxine showed an increase in expression of BDNF and exploring behavior compared to untreated rats, but a decrease in nNOS and fecal production.Conclusions Rats sustain damage to the brain after being subjected to chronic and comprehensive stress. Our research has indicated that combined EGb with venlafaxine enhances the protection of neurons and decreases damage to the brain, while relieving the side effects of synthetic antidepressants.QINXiao-song JINKui-he DINGBao-kun XIEShou-fu MAHui 2005Chinese Medical Journal2005,,5:8
2Effect of ginsenoside Rgl and Rhl on the anti-tumor activity of dendritic cell显示文摘AIM: To study the effect of ginsenoside Rgl and Rhl on the anti - tumor activity of dendritic cells (DC). METHODS: Effect of Rgl and Rhl on the production of IL- 12 p40 protein was detected by ELISA, and the IL- 12 p40 mRNA level of DC was monitored by RT- PCR. Anti - tumor activity of DC- LPAK was detemnined by neutral red staining assay. RESULTS: The results of ELLSA showed that Rgl and Rhl significantly enhanced the production of IL- 12 p40 of DC. Rgl at 1 mg/L and Rhl at 100 mg/L upregulated the IL- 12 p40 mRNA level. Rgl and Rhl enhanced the anti - tumor ability of DC, induced lyrnphokine and PHA activated killer (DC-LPAK) on human papillate tumor cell line. Each dose of Rgl can obviously accelerate the eytotoxity to L929 at the E: T ratio of 5 : 1 (P<0.05,0.01 ), while only Rhl 10 mg/L enhanced the eytotoxity ability of DC- LPAK (P < 0.05). CONCLUSION: Rgl and Rhl enhanced the production of IL-12 p40. This effect may be mediated by the increase in the mRNA level. As a result, Rg1 and Rhl oromote the ability of DC to stimulate the cytotoxitie aetieity of DC - LPAK.WANGYi HAOYu LOUJin-li MAHui QIUQuan-ying 2004中国病理生理杂志2004,20,10:3
3显示文摘LuoXinmin(罗新民) ZhangJingwen(张静文) MaHui(马辉)eta1 2011光学学报2011,7,:1
4显示文摘ZhangJingwen(张静文) LuoXinmin(罗新民) MaHui(马辉)etal 2011材料热处理2011,36,9:1
5显示文摘MAHui WANGYa-chaO MAYong-kun etal(马辉 王亚超 马永昆 等) 2014现代食品科技2014,30,3:1
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