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| 1 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 2 | Damage detection using the frequency-response-function curvature method 显示文摘 | Sampaio R P C Maia N M | 1999 | Journal of Sound and Vibration1999，226，： | 1 |
| 3 | Biological relevance of E-cadherin-catenin complex proteins in primary epithelial ovarian tumours显示文摘 | Faleiro-Rodrigues C Macedo-Pinto M Maia S S | | 0，，02： | 1 |
| 4 | Effect of finishing time and techniques on marginal sealing ability of two composite restorative materials显示文摘 | Lopes GC Franke M Maia HP | 2002 | J Prosthet Dent2002，88，1： | 1 |
| 5 | A review of vibration-based structural health monitoring with special emphasis on composite materials 显示文摘 | Montalv-o D Maia N M M Ribeiro A M R | 2006 | Shock and Vibration Digest2006，38，4： | 1 |
| 6 | A functional variant at a prostate cancer predispositionlocus at 8q24 is associated with PVT1 expression显示文摘 | Meyer KB Maia AT O'Reilly M | 2011 | PLoS Genet2011，7，10： | 1 |
| 7 | Nitrogen incorporation into titanium diboride films deposited by dc magnetron sputtering: Structural modifications 显示文摘 | SANCHEZ C M T FONSECA-FILHO H D MAIA DA COSTA M E H | 2009 | Thin Solid Films2009，517，19： | 1 |
| 8 | Perspective on fluid and solid dynamics in different pars plana vitrectomy systems显示文摘 | Magalh(a)es O Jr Maia M Rodrigues EB | | 0，，： | 1 |
| 9 | The use of transmissibility properties to estimate FRFs on modified structures 显示文摘 | Almeida R A B Urgueira A P V Maia N M M | 2010 | Shock and Vi- bration2010，17，4： | 1 |
| 10 | The transmissibility concept in multiple degrees of freedom systems 显示文摘 | Maia N M M Silva J M M Ribeiro A M R | 2001 | Mechanical Systems and Signal Processing2001，15，1： | 1 |
| 11 | Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection显示文摘 | VENTURA CV MAIA M VENTURA BV | 2016 | Arq Bras Oftalmol2016，79，1： | 1 |
| 12 | On the use of the transmissibility concept for the evaluation of frequency response functions显示文摘 | Urgueira A P V Almeida R A B Maia N M M | 2011 | Mechanical Systems and Signal Processing2011，25，3： | 1 |
| 13 | Angioten sin(1-7) antagonist A-779 attenuates the potentiation of bra dykinin by captopril in rats 显示文摘 | MAIA L G RAMOS M E FERNANDES L | 2004 | J Cardiovasc Pharmacol2004，43，： | 1 |
| 14 | Evolution of Peroxide-induced Thermomechanical Degradation of Polypropylene along the Extruder显示文摘 | A V Machado J M Maia S V Canevarolo | 2004 | J Appl Polym Sci2004，91，4： | 1 |
| 15 | Effect of grassland management on soil carbon sequestration in Rond(o)nia and Mato Grosso states,Brazil显示文摘 | MAIA S F OGLE S M CERRI C P | 2009 | Geoderma2009，149，12： | 1 |
| 16 | Solutions for a resonant elliptic system with coupling in RN显示文摘 | Furtado M F Maia L A Silva E A B | | 0，，： | 1 |
| 17 | Liver transplant for the treatment of giant hepatic hemangioma 显示文摘 | Ferraz AA Sette M J Maia M | 2004 | Liver Transpl2004，10，11： | 1 |
| 18 | Subretinal injection of preservative- free triamcinolone acetonide and supernatant vehicle in rabbits: an electron microscopy study 显示文摘 | Maia M Penha FM Farah ME | 2008 | Graefe''s Arch Clin Exp Ophthalmol2008，246，： | 1 |
| 19 | Refined X-ray crystallographic structure of the poliovirus 3C gene product 1 1 Edited By D. Rees显示文摘 | Steven C Mosimann Maia M Cherney Samuel Sia Steve Plotch Michael N.G James | 1997 | Journal of Molecular Biology1997，，5： | 1 |
| 20 | Damage detection using the frequency-response-function curvature method显示文摘 | Sampaio R P C Maia N M M Silva J M M | 1999 | Journal of Sound and Vibration1999，，5： | 1 |
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