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| 1 | B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors显示文摘The most common digestive system(DS)cancers,including tumors of the gastrointestinal tract(GIT)such as colorectal cancer(CRC),gastric cancer(GC)and esophageal cancer(EC)as well as tumors of DS accessory organs such as pancreatic and liver cancer,are responsible for more than one-third of all cancerrelated deaths worldwide,despite the progress that has been achieved in anticancer therapy.Due to these limitations in treatment strategies,oncological research has taken outstanding steps towards a better understanding of cancer cell biological complexity and heterogeneity.These studies led to new molecular target-driven therapeutic approaches.Different in vivo and in vitro studies have revealed significant expression of B7 homologue 3(B7-H3)among the most common cancers of the GIT,including CRC,GC,and EC,whereas B7-H3 expression in normal healthy tissue of these organs was shown to be absent or minimal.This molecule is able to influence the biological behavior of GIT tumors through the various immunological and nonimmunological molecular mechanisms,and some of them are shown to be the result of B7-H3-related induction of signal transduction pathways,such as Janus kinase 2/signal transducer and activator of transcription 3,phosphatidylinositol 3-kinase/protein kinase B,extracellular signal-regulated kinase,and nuclear factor-κB.B7-H3 exerts an important role in progression,metastasis and resistance to anticancer therapy in these tumors.In addition,the results of many studies suggest that B7-H3 stimulates immune evasion in GIT tumors by suppressing antitumor immune response.Accordingly,it was observed that experimental depletion or inhibition of B7-H3 in gastrointestinal cancers improved antitumor immune response,impaired tumor progression,invasion,angiogenesis,and metastasis and decreased resistance to anticancer therapy.Finally,the high expression of B7-H3 in most common cancers of the GIT was shown to be associated with poor prognosis.In this review,we summarize the established data from different GIT cancer-related studies and suggest that the B7-H3 molecule could be a promising prognostic biomarker and therapeutic target for anticancer immunotherapy in these tumors. | Petar Rasic Maja Jovanovic-Tucovic Marija Jeremic Slavisa M Djuricic Zorica V Vasiljevic Maja Milickovic Djordje Savic | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 2 |
| 2 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 3 | Description of the entropy algorithm as applied in the Datex-Ohmeda S/5 Entropy Module显示文摘 | VIERTIO-OJA H MAJA V SARKELA M | 2004 | Acta Anaesthesiol Scand2004，48，2： | 1 |
| 4 | Description of the entropy algorithm as applied in the Datex Ohmeda S/5 Entropy Module 显示文摘 | ViertioOja H Maja V Sarkela M | 2004 | Acta Anaesthesiol Scand2004，48，2： | 1 |
| 5 | Description of the entropy algorithm as applied in the Datex-Ohmeda S/5 Entropy Module显示文摘 | Viertio-Oja H Maja V Sarkeh M | 2004 | Acte Anaesthesiol Scand2004，48，： | 1 |
| 6 | Description of the entropy algorithm applied in the Datex-Ohmeda s/5Entropy Module显示文摘 | Viertio-Oja H Maja V Sarkela M | | 0，，02： | 1 |
| 7 | Description of the Entropy algorithmas applied in the Datex-Ohmeda S/5 Entropy Module显示文摘 | Viertio-Oja H Maja V Sarkela M | 2004 | Acta Anaesthesiol Scand2004，48，： | 1 |
| 8 | Description of the Entropy algorithm as applied in the Datex-Ohmeda S/5 Entropy Module显示文摘 | Viertio-Oja H Maja V Sarkela M | 2004 | Acta Anaesthesiol Scand2004，48，： | 1 |
| 9 | Description of the en - tropy algorithm as applied in the Datex - Ohrneda S/5 Entropy- Module显示文摘 | Viertio - OjaH Maja V SarkelaM | 2004 | ActaAnaesthesiolScand2004，48，2： | 1 |
| 10 | Description of the Entropy algorithm as applied in the Datex-Ohmeda S/5 Entropy Module显示文摘 | Vierti-Oja H Maja V S-rkel M | 2004 | Acta Anaesthesiologica Seandinavica2004，48，： | 1 |
| 11 | Description of the Entropy algorithm as applied in the Datex-Ohmcda S/5entropy module显示文摘 | VIERTIO-OJA H MAJA V SARKELA M | 2004 | Acta Anaesthesiol Scand2004，48，2： | 1 |
| 12 | Description of the Entropy algorithm as applied in the Datex-Ohmeda S/5 Entropy Module显示文摘 | Vierti(o)-Oja H Maja V S(a)kel(a) M | 2004 | Acta Anaesthesiol Scand2004，48，2： | 1 |
| 13 | Description of the entropy algo- rithm as applied in the Datex-ohmeda s/5 entropy module显示文摘 | Viertiooja H Maja V Sarkela M | 2004 | Acta An- aesthesiol Scand2004，48，： | 1 |
| 14 | Description of the entropy algorithm as applied in the Datex-Ohmeda S/5 entropy module显示文摘 | Viertio-Oja H Maja V Sarkela M | 2004 | Acta Anaesthesiol Scand2004，48，： | 1 |
| 15 | Description of the entropy algorithm as applied in the Datex-Ohmeda S/5 Entropy Module显示文摘 | Maja V Sarkela M | 2004 | Acta Anaesthesiol Scand2004，48，2： | 1 |
| 16 | Differences in risk factors for local and distant recurrence after breast-conserving therapy or masteetomy for stage Ⅰ and Ⅱ breast cancer:Pooled results of two large european randomized trials显示文摘 | Adri C V Maja N Johannes L | 2001 | J Clin Oncol2001，19，6： | 1 |
| 17 | Delayed vaccine virus replication in chickens vaccinated subcutaneously with an immune complex Infectious bursal disease vaccine:Quantification of vaccine virus by real-time polymerase chain reaction显示文摘 | Judit I Maja V Krisztina U | 2005 | Can J Vet Res2005，69，2： | 1 |
| 18 | Description of the Entropy algorithm as applied in the Datex-Ohmeda S/5 Entropy Module显示文摘 | ViertiO-Oja H Maja V Sarkela M | 2004 | Acta Anaesthesiol Scand2004，48，： | 1 |
| 19 | Description of the Entropy al- gorithm as applied in the Datex-Ohmeda S/5 entropy module 显示文摘 | Viertio-Oja H Maja V Sarkela M | 2004 | Aeta Anaesthesiol Seand2004，48，： | 1 |
| 20 | Bridging the gap between social animal and unsocial machine A survey of social signal processing显示文摘 | Alessandro V Maja P Dirk H | 2012 | IEEE Transactions on Affective Computing2012，3，1： | 1 |
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