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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | The x-Kernel: A platform for accessing internet resourees 显示文摘 | L L Peterson N C Hutchinson S W O'Malley H C Rao | 1990 | IEEE Computer (S0018-9162)1990，23，5： | 1 |
| 3 | Assessment of bio- markers of protein anabolism in skeletal muscle during the life span of the rat : sarcopenia despite elevated protein synthesis 显示文摘 | Kimball S R O' Malley J P Anthony J C | 2004 | Am J Physiol Endocrinol Metab2004，287，4： | 1 |
| 4 | High-level JAG1 mRNA and protein predict poor outcome in breast cancer显示文摘 | Dickson B C Mulligan A M Zhang H Lockwood G O' Malley F P Egan S E | 2007 | Mod Pathol2007，20，： | 1 |
| 5 | As sessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated pro rein synthesis显示文摘 | KIMBALL S R O'MALLEY J P ANTHONY J C | 2004 | Am J Physiol Endocrinol Metab2004，287，4： | 1 |
| 6 | An evaluation of the Sysmex NE-8000 hematology analyzer显示文摘 | Hallawell R O Malley C Hussein S | 1991 | Am J Clin Pathol1991，96，： | 1 |
| 7 | Low dose CT of the heart: A quantum leap into a new era of cardiovascular imaging 显示文摘 | Mallei E Martini C De Crescenzo S | 2010 | Radiol Med2010，115，： | 1 |
| 8 | An evaluation of the Sys mex NE-8000 hematology analyzer显示文摘 | Hallawell R Malley C Hussein S | 1991 | Am J Clin pathol1991，96，5： | 1 |
| 9 | Signaling organogenesis in parasitic angiosperms : xenognosin generation, perception, and response显示文摘 | Keyes S J O'malley R C Kim D | 2000 | Journal of Plant Growth Regulation2000，19，2： | 1 |
| 10 | An evaluation of the Sysmex NE-8000 hematology analyzer显示文摘 | Hallawell R O'Malley C Hussein S | 1991 | Am J Clin Pathol1991，96，5： | 1 |
| 11 | The skeletal response to estrogen is impaired in female but not in male steroid receptor coactivator (SRC)-1 knock out mice显示文摘 | Modder U I Sanyal A Xu J O'Malley B W Spelsberg T C Khosla S | 2008 | Bone2008，42，： | 1 |
| 12 | Breast implants following mastectomy in women with early-stage breast cancer:prevalence and impact on survival显示文摘 | Le G M O'Malley C D Glaser S L | 2005 | Breast Cancer Res2005，7，2： | 1 |
| 13 | Agonist- antagonist common drive during fatiguing knee exten- sion efforts using surface electromyography 显示文摘 | Mullany H O'Malley M Gibson A S C | 2002 | Journal of Electromyography and Kinesiology2002，12，5： | 1 |
| 14 | Breast implants following mastectomy in women with early-stage breast cancer:prevalence and impact on survival显示文摘 | Le G O' Malley C Glaser S | 2005 | Breast Cancer Res2005，7，2： | 1 |
| 15 | An evaluation of the Sysmex NE-8000 hematology analyzer显示文摘 | Hallawell R O'Malley C Hussein S | 1991 | Am J Clin Pathol1991，96，： | 1 |
| 16 | Genetic variation in the extreme endemic Pedicularis furbishiae (Scrophulariaceae)显示文摘 | Waller D M O'Malley D M Gawler S C | 1987 | Cons Biol1987，1，： | 1 |
| 17 | Marked prolongation of porcine renal xenograft survival in baboons through the use of α-1, 3 galactosyltransferase gene-knock out donors and the cotransplantation of vascularized thymic tissue显示文摘 | Yamada K Yazawa K Shimizu A Iwanaga T Hisashi Y Nuhn M O'Malley P Nobori S Vagefi P A Patience C Fisherman J Cooper D K C Hawley R J Greenstein J Schuurman H-J Awwad M Sykes M Sachs D H | 2005 | Nature Medicine2005，11，1： | 1 |
| 18 | Estimating Cloud Type from Pyranometer Observations 显示文摘 | Duchon C E Malley M S | 1999 | Journal of Applied Meteorology1999，38，1： | 1 |
| 19 | Estimating cloud type from pyranometer observations显示文摘 | DUCHON C E O'MALLEY M S | 1999 | Journal of Applied Meteorology1999，38，1： | 1 |
| 20 | Pro- ceedings of the National Academy of Sciences of the United States of America显示文摘 | Schweitzer B Wiltshire S Lambert J O'Malley S Kukanskis K Zhu Z Kingsmore S F Lizardi P M Ward D C | 2000 | 97(18) : 101132000，97，10： | 1 |
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