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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Appling the TranstheoreticalModel to Exercise:A Systematic and Comprehensive Review of theLiterature显示文摘 | Spencer L Adams T B Malone S | 2006 | Health Promotion Practice2006，7，4： | 1 |
| 3 | Paraquat poisoning;a review of nineteen cases显示文摘 | Malone J D Carmody M Keogh B | 1971 | J Ir Med Assoc1971，64，405： | 1 |
| 4 | Overview of the line-imaging VISAR diagnostic at the National Ignition Facility (NIF) 显示文摘 | MALONE R M FROGGET B C KAUFMAN M I | 2006 | Proceedings of SPIE2006，6342，： | 1 |
| 5 | Organic Antimony Compounds as Lubricant Additives显示文摘 | H H Farmer B W Malone H F Tompkins | 1967 | Lubrication Engineering1967，23，3： | 1 |
| 6 | The Effects of 8 Weeks of Creatine Monohydrate and Glutamine Supplementation on Body Composition and Performance Measures 显示文摘 | Lehmkubl M Malone M Justice B | 2003 | The Journal of Strength & Conditioning Research2003，17，3： | 1 |
| 7 | A geographic information system forecast model for strategic control of fasciolosis in Ethiopia显示文摘 | Yilma J M Malone J B | 1998 | Vet Parasitol1998，74，7： | 1 |
| 8 | Long-term follow-up of efficancy and safety of megavoltage ridiotherapy in high-risk giant cell tumors of bone显示文摘 | Malone S O'sullivan B Catton C | 1995 | Int J Radiat Oncol Biol Phys1995，33，3： | 1 |
| 9 | Use of satellite remote sensing and geographic information systems to model the distribution and abundance of snail intermediate hosts in Africa: A preliminary model for Biomphalaria pfeifferi in Ethiopia显示文摘 | Kristensen T K Malone J B Carrol J C | 2001 | Acta Trop2001，79，1： | 1 |
| 10 | 1-alky-2-acetyl-snglycero-3-phosphocholine (platelet-activatingfactor) stimulate clcUm influx in rabbit plateters 显示文摘 | Lee TC Malone B Blank ML | 1981 | Biochem Biophys Res Commun1981，102，4： | 1 |
| 11 | Policies and structures for spinning off new companies from research and development organizations 显示文摘 | Edward B Roberts Denis E Malone | 1995 | Working Paper1995，，3： | 1 |
| 12 | Policies and structures for spinning out new companies from research and development organizations显示文摘 | Roberts E B Malone D E | 1996 | R&D Management1996，26，1： | 1 |
| 13 | Sclerosing rhabdomyosarcoma in childhood:case report and review of the literature显示文摘 | Vadgama B Sebire N J Malone M Ramsay A D | 2004 | Pediatr Dev Pathol2004，7，4： | 1 |
| 14 | Organic Antimony Compounds as Lubricant Additive 显示文摘 | Farmer H H Malone B W Tompkins H F | 1967 | Lub Eng1967，23，3： | 1 |
| 15 | Biology-based mapping of vector-borne parasites by geographic information systems and remote sensing显示文摘 | Malone J B | 2005 | Parassitologia2005，47，1： | 1 |
| 16 | Microarrays, deep sequencing and the true measure of the transeriptome 显示文摘 | Malone J H Oliver B | 2011 | BMC Biology2011，9，1： | 1 |
| 17 | The effects of 8 weeks of creatine monohydrate and glutamine supplementation on body composition and performance measures显示文摘 | Lehmkuhl M Malone M Justice B | 2003 | J Strength Cond Res2003，17，3： | 1 |
| 18 | Organic Anti- mony Compounds as Lubricant Additives 显示文摘 | Farmer H H Malone B W Tompkins H F | 1967 | Lubrication Engineering1967，23，3： | 1 |
| 19 | Appling the transtheoretical model to exercise: A systematic and comprehensive review of the literature 显示文摘 | Spencer L Adams T B Malone S | 2006 | Health Promotion Practice2006，7，4： | 1 |
| 20 | Is there a place for medical students as teachers in the education of junior residents?显示文摘 | Wirth K Malone B Barrera K | 2014 | Am J Surg2014，207，： | 1 |
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