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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Production of taxol and its analogues from cell cultures of Taxus wallichiana显示文摘 | Veeresham C Mamatha R Babu C P | 2003 | Pharmaceutical Biology2003，41，6： | 1 |
| 3 | Geochemistry of fluoride rich groundwater in Kolar and Tumkur Districts of Karnataka显示文摘 | Mamatha P Sudhakar M R | 2010 | Environmental Earth Sciences2010，61，1： | 1 |
| 4 | Geochemistry of fluoride rich groundwater in Kolar and Tumkttr Districts of Karnataka显示文摘 | Mamatha P Sudhakar M R | 2010 | Environmental Earth Sciences2010，61，1： | 1 |
| 5 | Geochemistry of fluoride rich groundwater in Kolar and Tumkur Districts of Karnataka显示文摘 | Mamatha P Sudhakar M R | 2010 | Environmental Earth Sciences2010，61，1： | 1 |
| 6 | Medium optimization of gammalinolenic acid production in Mucor rouxii CFR-G15 using RSM 显示文摘 | Mamatha S Ravi R Venkateswaran G | 2008 | FABT2008，1，4： | 1 |
| 7 | Effect of processing on major carotenoid levels in corn (Zea mays) and selected vegetables: Bioavailability of lutein and zeaxanthin from processed corn in mice显示文摘 | MAMATHA B S ARUNKUMAR R BASKARAN V | 2012 | Food and Bioprocess Technology2012，5，4： | 1 |
| 8 | Production of taxol and its analogs from cell cultures of Taxus wallichiana 显示文摘 | Veeresham C Mamatha R Prasad Babu CH | 2003 | Pharma Biol2003，41，： | 1 |
| 9 | Int J Elec trochem Sci显示文摘 | Manjunatha J G Swamy B E K Deepa R Krishna V Mamatha G P Chandra U Shankar S S Sherigara B S | 2009 | 4 : 6622009，4，： | 1 |
| 10 | Medium optimization of γ-linolenic acid production in Mucor rouxii CFR-G15 using RSM显示文摘 | MAMATHA S S RAVI R VENKATESWARAN G | 2008 | Food Biooroeess Teeimol2008，1，4： | 1 |
| 11 | Production of taxol and its analogues from cell cultures of Taxus wallichiana显示文摘 | VEERESHAM C MAMATHA R PRASAD BABU C H | 2003 | Pharmaceutical Biology2003，41，6： | 1 |
| 12 | Cytosolic iron superoxide dismutase is a part of the triacylglycerol biosynthesis complex in oleaginous yeast 显示文摘 | Sumana Raychaudhuri Mamatha M Reddy Naveen R Rajkumar | 2003 | Biochem J2003，372，： | 1 |
| 13 | Geochemistry of fluoride rich groundwater in Kolar and Tumkur Districts of Karnataka显示文摘 | Mamatha P Sudhakar M R | 2010 | Environmental earth science2010，61，1： | 1 |
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