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| 1 | Significance of serum leptin and adiponectin levels in Egyptian patients with chronic hepatitis C virus associated hepatic steatosis and fibrosis显示文摘AIM:To study serum levels of leptin and adiponectin in patients with chronic hepatitis C virus infection genotype-4(HCV-4) related steatosis and fibrosis.METHODS:We prospectively studied 45 untreated men with chronic HCV-4,with proven steatosis(group Ⅰ,30 patients),and fibrosis(group Ⅱ,15 patients),on liver biopsy.In addition,15 healthy men(group Ⅲ),matched for age,and body mass index were included.However,we excluded another five patients with steatohepatitis,and six patients with cirrhosis.We measured total serum leptin and adiponectin levels,as potential predictors for liver steatosis and fibrosis.Also,a correlation between these adipokines and various clinical and laboratory data were evaluated.All subjects were selected from Tropical and Internal medicine departments,Menoufiya University Hospital,Menoufiya,Egypt,during the period from February 2010 to August 2011.RESULTS:In group Ⅰ,severity of hepatic steatosis was mild,moderate,and severe,in 19 patients(63.5%),8 patients(26.5%),and 3 patients(10%),respectively.In contrast,in group Ⅱ,hepatic fibrosis was found to be in stage 1,2,and 3,in 6 patients(40%),in 6 patients(40%),and in 3 patients(20%),respectively.On comparing group Ⅰ with group Ⅱ,there was a significant decrease in serum adiponectin levels(131.4 ± 7.91 pg/mL vs 436 ± 9.75 pg/mL,P < 0.001),while there was no significant difference between both groups regarding serum leptin levels(34.69 ± 7.69 ng/mL vs 35.17 ± 1.06 ng/mL,P > 0.05).However,in the same group,when compared with group Ⅲ,there was a significant increase in serum leptin levels(34.69 ± 7.69 ng/mL vs 10.69 ± 0.84 ng/mL,P < 0.001),while there was a significant decrease in serum adiponectin levels(131.4 ± 7.91 pg/mL vs 342.4 ± 44.48 pg/mL,P < 0.001).In contrast,in group Ⅱ,when compared with group Ⅲ,there was a significant increase in serum leptin and adiponectin levels(35.17 ± 1.06 ng/mL vs 10.69 ± 0.84 ng/mL,P < 0.001,and 436 ± 9.75 pg /mL vs 342.4 ± 44.48 pg/mL,P < 0.05,respectively),while there was no significant difference between both groups regarding serum creatinine(0.83 ± 0.34 vs 0.89 ± 0.24,P > 0.05).On the other hand,serum leptin was not correlated with serum adiponectin in group Ⅰ and in group Ⅱ(r = 0.09,P > 0.05,and r =-0.1,P > 0.05,respectively).However,serum adiponectin was significantly negatively correlated with serum aspartate transaminase in group Ⅰ,but no correlation detected in group Ⅱ(r =-0.39,P > 0.05,and r =-0.03,P > 0.05).CONCLUSION:In male patients with chronic HCV-4,serum adiponectin levels are elevated in hepatic fibrosis,but decreased in steatosis.Therefore,in contrast to leptin,adiponectin may be used as a non-invasive marker. | Tarek E Korah Sawsan El-Sayed Maathir K ElShafie Ghada E Hammoda Manal A Safan | 2013 | World Journal of Hepatology2013，5，2： | 7 |
| 2 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 3 | Melatonin and/or rowatinex attenuate streptozotocin-induced diabetic renal injury in rats显示文摘The study aimed to explore the prophylactic effect of melatonin, rowatinex; a naturally occurring renal drug, and its combination on diabetic nephropathy in type 2 diabetic rats. Diabetes was induced by intraperitoneal injection of a single dose of streptozotocin(50 mg/g body weight). Three days before diabetes induction, rats were daily treated with melatonin, rowatinex and their combination continuously for 8 weeks. Evaluation was done through measuring blood urea nitrogen(BUN), serum uric acid, serum creatinine, urine creatinine, creatinine clearance, nitric oxide(NO), malondialdehyde(MDA), superoxide dismutase(SOD), glutathione(GSH), total antioxidant capacity(TAC),kidney injury molecule-1(KIM-1), heat shock protein-70(HSP-70), caspase-3, transforming growth factor β1(TGFβ1), DNA degradation by the comet assay and total protein contents. Histopathologic study was also done for the kidney and the pancreas. Drastic changes in all measured parameters of the diabetic rats were observed. Treatment with melatonin and rowatinex showed amelioration to variable degrees. In conclusion, melatonin showed the most potent effect on protecting rats from deleterious action of diabetic nephropathy followed by its combination with rowatinex. | Tarek K Motawi Samia A Ahmed Manal A Hamed Shohda A El-Maraghy Wessam M Aziz | 2019 | The Journal of Biomedical Research2019，33，2： | 2 |
| 4 | Bio-energy and Economic Analysis of Soybean-based Crop Production Systems in Central India显示文摘 | MANAL K G SAHA K P GHOSH P K | 2002 | Biomass and Bio2-energy2002，23，5： | 1 |
| 5 | Electrostatic fabrication of ultrafine conducting fibers:polyaniline/polyethylene oxide blends显示文摘 | Ian D Norris Manal M Shaker Frank K | 2000 | Synthetic Materials2000，114，： | 1 |
| 6 | Scalp Nerve Block in Chil-dren Undergoing a Supratentorial Craniotomy:A Randomized Con-trolled Study显示文摘 | Manal el Gohary MG Girgis K Nabil S | 2009 | Asian Journal of Scientific Research2009，2，： | 1 |
| 7 | Kinematic and kinetic analysis of planned and unplanned gait termination in chil- dren 显示文摘 | Ridge ST Henley J Manal K | 2012 | Gait Posture2012，37，2： | 1 |
| 8 | Echinococcus granulosus in Jordan:Assessment of Various Antigenic Preparations for Use in the Serodiagnosis of Surgically Confirmed Cases Using Enzyme immuno Assays and the Indirect Haemagglutination Test显示文摘 | Manal A Nasrieh Sami K Abdel-Hafez | 2004 | Diagnostic Microbiology and Infectious Disease2004，48，： | 1 |
| 9 | Electrostatic fabrication of ultrafine conducting fibers: polyaniline/polyethylene oxide blends显示文摘 | Ian D Norris Manal M Shaker Frank K Ko Alan G MacDiarmid | 2000 | Synthetic Metals2000，，2： | 1 |
| 10 | The influence of foot progressionangle on the knee adduction moment during walking and stairclimbing in pain free individuals with knee osteoarthritis 显示文摘 | Guo M Axe MJ Manal K | 2007 | Gait Posture2007，26，3： | 1 |
| 11 | Gait and neuromuscular asymmetries after acute anterior eruciate ligament rupture 显示文摘 | Gardinier ES Manal K Buchanan TS | 2012 | Med Sci Sports Exert2012，44，8： | 1 |
| 12 | The influence of foot abduction on differences between two-dimensional and three-dimensional rearfoot motion显示文摘 | MCCLAY I MANAL K | 1998 | Foot Ankle1998，19，1： | 1 |
| 13 | A novel method for displaying gait and clinical movement analysis data 显示文摘 | Manal K Stanhope S J | 2004 | Gait and Posture2004，20，2： | 1 |
| 14 | Three-dimensional kinetic analysis of running: significance of secondary planes of motion显示文摘 | MCCLAY I MANAL K | 1999 | Med Sci Sports Exe1999，31，11： | 1 |
| 15 | Comparison of surface mounted markers and attach ment methods in estimating tibial rotations during walking :an in vivo study 显示文摘 | McClay I | 2000 | Gait and Posture2000，11，： | 1 |
| 16 | Effects of X-Stop device on sagittal lumbar spinekinematics in spinal stenosis显示文摘 | Manal S Efthimios K Malcolm N | 2006 | J Spine Disord Tech2006，19，5： | 1 |
| 17 | The influence of foot progression angle on the knee adduction moment during walking and stair climbing in pain free individuals with knee osteoarthritis显示文摘 | Guo M Axe M J Manal K | 2007 | Gait Posture2007，26，： | 1 |
| 18 | Estimation of ligament loading and anterior tibial translation in healthy and ACL-deficient knees during gait and the influence of in- creasing tibial slope using EMG-driven approach 显示文摘 | Shao Q MacLeod TD Manal K | 2010 | J Bi- omech2010，43，13： | 1 |
| 19 | A three-dimensional data visualization technique for reporting movement pattern deviations显示文摘 | Chang C C Hamill J | 2005 | Journal of Biomechanics2005，38，11： | 1 |
| 20 | The influence of foot progression angle on the knee adduction moment during walking and stair climbing in pain free individuals with knee osteoarthritis 显示文摘 | Guo M Axe M J Manal K | 2007 | Gait Posture2007，26，3： | 1 |
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