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| 1 | Antimicrobial potential of selected brown seaweeds from Vedalai coastal waters,Gulf of Mannar显示文摘Objective:To evaluate the antimicrobial activity of Turbinaria conoides(T.conoides).Padina gymnospora(P.gymnospora) and Sargassum tenerrimum against human bacterial and fungal pathogens.Methods:The antimicrobial activities of the extracts against various organisms were tested by using disc diffusion method.Results:The methanol extract showed the better result than the other extracts.Whereas,the strong antibacterial inhibition was noted in methanol extracts of P.gymnospora against Bacillus subtilus(26.33±1.86) and the mild inhibition of ethanol extracts from T.conoides against Klebsiella pneumoniae(2.33±0.51).Acetone extraction of P. gymnospora had strong antifungal inhibition against Cryptococcus neoformans(23.00±1.78), and acetone extract of T.conoides had mild inhibition against Aspergillus niger(3.00±0.89). Conclusions:The seven different solvent extracts of seaweeds used in the present study have shown significant bacterial action.Further,a detailed study on the principle compound in the seaweeds which is responsible for antimicrobial activity is still needed and it can be achieved by using advanced separation techniques. | Manivannan K Karthikai devi G Anantharaman P Balasubramanian T | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 9 |
| 2 | Human sperm immobilization effect of Carica papaya seed extracts: an in vitro study显示文摘Aim: To examine if the seed extracts of Carica papaya, which showed antispermatogenic/sperm immobilization properties in animal models, could cause human sperm immobilization in vitro. Methods: Chloroform extract, benzene chromatographic fraction of the chloroform extract, its methanol and ethyl acetate sub-fractions and the isolated compounds from the sub-fractions i.e., ECP 1 & 2 and MCP 1 & 2, of the seeds of Cadca papaya were used at concentrations of 0.1%, 0.5%, 1% and 2%. Sperm motility was assessed immediately after addition of extracts and every 5 minutes thereafter for 30 minutes. Results: There were dose-dependent spermicidal effects showing an instant fall in the sperm motility to less than 20 % at 2 % concentration. Isolated compounds ECP 1 & 2 were more effective inducing a motility of less than 10%. Many of the spermatozoa became vibratory on the spot. Total inhibition of motility was observed within 20 - 25 min at all concentrations of all products. Scanning and transmission electron microscopy revealed deleterious changes in the plasma membrane of the head and mid-piece of spermatozoa. Sperm viability test and the number of abnormal spermatozoa after completion of incubation suggested that the spermatozoa were infertile. The effects were spermicidal but not spermiostatic as revealed by the sperm revival test. Conclusion: The results reveal spermicidal activity in vitro of the seed extracts of Carica papaya. | Nirmal K Lohiya Lalit K Kothari B Manivannan Pradyumna K Mishra Neelam Pathak | 2000 | Asian Journal of Andrology2000，2，2： | 6 |
| 3 | Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy显示文摘 | Leal EC Manivannan A Hosoya K | 2007 | Invest Ophthalmol Vis Sci2007，48，11： | 1 |
| 4 | Selective toxicity of Zn O nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation显示文摘 | Premanathan M Karthikeyan K Jeyasubramanian K Manivannan G | 2011 | Nanomedicine2011，7，2： | 1 |
| 5 | Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy显示文摘 | Leal EC Manivannan A Hosoya K Terasaki T Ctmha-Vaz J Ambrosio AF | 2007 | Invest Ophthalmol Vis Sci2007，48，11： | 1 |
| 6 | An overview of fluoroquino- lones显示文摘 | Somasundaram S Manivannan K | 2013 | Annu Rev Res Biol2013，3，3： | 1 |
| 7 | Electrical and FTIR studies on Al substituted Mn-Zn mixed ferrites 显示文摘 | CHANDRASEKARAN G SELVANANDAN S MANIVANNANE K | 2004 | J Mater Sci Mater Electro2004，15，： | 1 |
| 8 | Electrical and FTIR studies on A1 substituted Mn-Zn mixed ferrites显示文摘 | CHANDRASEKARAN G SELVANANDAN S MANIVANNANE K | 2004 | Journal of Materials Science: Materials in Electronics2004，15，1： | 1 |
| 9 | Tuning the position of the redox couples in materials with NA- SICON structure by anionic substitution显示文摘 | Padhi A K Manivannan V Goodenough J B | 1998 | J Electro- chem Soc1998，145，： | 1 |
| 10 | Preperoxisomal vesicles can form in the absence of PEX3 显示文摘 | Knoops K Manivannan S Cepinska M N | 2014 | J Cell Biol2014，204，5： | 1 |
| 11 | Antibacterial properties of selected green seaweeds from Vedalai Coastal Waters; Gulf of Mannar Marine biosphere reserve 显示文摘 | Karthikaidevi G Manivannan K Thirumaran C | 2009 | Global J Pharmacol2009，3，2： | 1 |
| 12 | Antidiabetic activity of the mangrove species Ceriops decandra in alloxan-induced diabetic rats显示文摘 | Nabeel M A Kathiresan K Manivannan S | 2010 | J Diabetes2010，2，2： | 1 |
| 13 | Effect of unilateral eyestalk ablation on the biochemicalchanges of edible portunidae crab portunus sanguinolen-tus ( HERBST) 显示文摘 | Sudhakar M Manivannan K Soundarapandian P | 2009 | Middle-East Journal of ScientificResearch2009，4，3： | 1 |
| 14 | Effect of Medium Composition on Glucose Oxidase Production by Penicillium fellutanum Isolated from Mangrove Rhizosphero soil显示文摘 | Manivannan S Kathiresan K | 2007 | Resoaroh Journal of Microbi- ology2007，2，3： | 1 |
| 15 | Tuning the position of the redox couples in materials with NA- SICON structure by anionic subsitiution 显示文摘 | Goodenough J B Manivannan V Padhi A K | 1998 | J Elect- rochem Soc1998，145，5： | 1 |
| 16 | Tuning the Position of the Redox Couples in Materials with NASICON Struc ture by Anionic Substitution显示文摘 | Padhi A K Manivannan V Goodenough J B | 1998 | Journal of the Electrochemical Society1998，145，5： | 1 |
| 17 | Electrical and FTIR studies on Al substituted Mn-Zn mixed ferrites显示文摘 | CHANDRASEKARAN G SELVANANDAN S MANIVANNANE K | 2004 | J Mater Sci- Mater Electro2004，15，1： | 1 |
| 18 | Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy显示文摘 | Leal EC Manivannan A Hosoya K | 2007 | Invest Ophthalmol Vis Sci2007，48，11： | 1 |
| 19 | Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy显示文摘 | Leal EC Manivannan A Hosoya K Terasaki T Cunha-Vaz J Ambrosio AF | 2007 | Invest Ophthcdmol Vis Sci2007，48，11： | 1 |
| 20 | On the geometric equivalence of certain discrete integrable Heisenberg ferromagnetic spin chains显示文摘 | DANIEL M MANIVANNAN K | 1999 | Journal of Mathematical Physics1999，40，6： | 1 |
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