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| 1 | Cannabidiol does not display drug abuse potential in mice behavior显示文摘Recent evidence suggests that cannabidiol(CBD)may be useful for the treatment of different neuropsychiatric disorders.However,some controversy regarding its profile as a drug of abuse hampers the further development of basic and clinical studies.In this study,the behavioral profile of CBD as a potential drug of abuse was evaluated in C57BL/6J mice.Reinforcing properties of CBD(15,30,and 60 mg/kg;i.p.)were assessed using the conditioned place preference(CPP)paradigm.Spontaneous withdrawal symptoms and motor activity in the open field were examined 12 h after the last CBD administration(30 mg/kg/12 h,i.p.,6 days).CBD plasma concentrations were measured at 2,4,8,12,and 24 h after the administration of CBD(30 mg/kg,i.p.).Furthermore,an oral CBD selfadministration paradigm(50 mg/kg;CBD water-soluble 1.2 mg/mL)was performed to evaluate whether this drug produced any effects on motivation compared with a non-reinforcing substance(water).We found that CBD failed to induce CPP,withdrawal symptoms,or altered motor behavior 12 h after its administration.At that time,only traces of CBD were detected,ensuring that the lack of alterations in somatic signs and locomotor activity was not due to residual drug in plasma.Interestingly,mice displayed similar motivation and consumption of CBD and water.Taken together,these results show that CBD lacks activity as a drug of abuse and should stimulate the development of the basic and clinical studies needed to elucidate its potential therapeutic use for the treatment of neuropsychiatric and drug use disorders. | Adrián Viudez-Martínez María S.García-Gutiérrez Juan Medrano-Relinque Carmen M.Navarrón Francisco Navarrete Jorge Manzanares | 2019 | Acta Pharmacologica Sinica2019，40，3： | 2 |
| 2 | Selenium pharmaconutn - tion in sepsis : to give or not to give Is this still the question 显示文摘 | Manzanares W Langlois PL Hanly G | 2013 | Nutrition2013，29，1112： | 1 |
| 3 | Dilute sulfuric acid pretreatment of cardoon for ethanol produc- tion 显示文摘 | Ballesteros I Ballesteros M Manzanares P | 2008 | Biochemical Engineering Journal2008，42，1： | 1 |
| 4 | Plasma Fatty Acid-Binding Protein 4 Increases with Renal Dysfunction in Type 2 Diabetic Patients without Microalbuminuria显示文摘 | Cabré Anna Lázaro Iolanda Girona Josefa Manzanares Josep M Marimón Francesc Plana Núria Heras Mercedes Masana Lluís | 2008 | Clinical Chemistry2008，，1： | 1 |
| 5 | Hypontre- mia in the neurocritioal care patient: an approach based on current evidence显示文摘 | Manzanares W Aramendi I Langloispl etal | 2015 | Med Intensiva2015，39，4： | 1 |
| 6 | The Distribution and Origin of Trace Elements in a UK Coal:the Importance of Pyrite显示文摘 | Spears D A Manzanares Papayanopous L I Booth C A | 1999 | Fuel1999，78，14： | 1 |
| 7 | Triggering ovulation with gonadotropin-releasing hormoneagonist in in vitro fertilization patients with polycystic ovariesdoes not cause ovarian hyperstimulation syndrome despitevery high estradiol levels 显示文摘 | Manzanares MA G 6 mez-Palomares JL Ricciarelli E | 2010 | Fertil Steril2010，93，4： | 1 |
| 8 | Cannabidiol as a Potential Treatment for Anxiety Disorders 显示文摘 | Blessing EM Steenkamp MM Manzanares J | 2015 | Neurotherapeutics2015，12，4： | 1 |
| 9 | Risk of Episiotomy and Perineal Lacerations Recurring After First Delivery显示文摘 | Sebastian Manzanares Davinia Cobo Maria Dolores Moreno‐Martínez Mar Sánchez‐Gila Alicia Pineda | 2013 | Birth2013，，4： | 1 |
| 10 | Epidural analgesia and the rate of cesarean delivery显示文摘 | Rodriguez Hesles Valavdzquez C Manzanares Galan S | | 0，，9： | 1 |
| 11 | On the im- plementation of security policies with adaptative encryption 显示文摘 | Manzanares A I Sierra C J M Marquez J T | 2006 | Computer Communications2006，29，2： | 1 |
| 12 | Differential Expression of three α- galactosidases Genes and single β- galactosidase gene from Aspergillus niger显示文摘 | de Vries R P Van Den Broeck H C Dekkers E Manzanares P de Graaff L Visser J | 1999 | Applied and Enviromental Microbiology1999，65，6： | 1 |
| 13 | Purification and characterization of anα -L -rhamnosidase from Aspergillus niger 显示文摘 | Manzanares P de Graaff L H Visser J | 1997 | FEMS Microbiology Letters1997，157，2： | 1 |
| 14 | Evaluation ofsteam explosion pre-treatment for enzymatic hydrolysis ofsunflower stalks显示文摘 | Ruiz E Cara C Manzanares P | 2008 | Enzyme and Microbial Technology2008，42，2： | 1 |
| 15 | Purification and characterization of an α-L -rhamnosidase from Aspergillus nidulans 显示文摘 | Manzanares P Orejas M Ibanez E | 2000 | Letters in Applied Microbiology2000，31，3： | 1 |
| 16 | Mapping of one major gene and of QTLs involved in resistance to clubroot in Brassica napus显示文摘 | Manzanares -Danleux MJ Delourme R Baron F | 2000 | Theor Appl Genet2000，101，5： | 1 |
| 17 | Turgor maintenance, osmotic adjustment and soluble sugar and praline accumulation in 49 pea cultivars in response to water stress显示文摘 | Francisco J Manzanares M Eusebio F | 1998 | Field Crops Res1998，59，3： | 1 |
| 18 | Evaluation of steam explosion pre-treatment for enzymatic hydrolysis of sunflower stalks显示文摘 | Encarnacion Ruiz Cristobal Cara Paloma Manzanares | 2008 | Enzyme and Microbial Technology2008，42，： | 1 |
| 19 | Learning strategies used by beginning and intermediate ESL students 显示文摘 | O' Malley J M Chamot A U Stewner - Manzanares G Kupper L and Russo R 1985 | 1985 | Language Learning1985，35，1： | 1 |
| 20 | Learning strategies used by beginning and intermediate ESL students 显示文摘 | OMalley J M Chamot A U Stewner - Manzanares G | 1985 | Language learning1985，35，1： | 1 |
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