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| 1 | Cannabidiol does not display drug abuse potential in mice behavior显示文摘Recent evidence suggests that cannabidiol(CBD)may be useful for the treatment of different neuropsychiatric disorders.However,some controversy regarding its profile as a drug of abuse hampers the further development of basic and clinical studies.In this study,the behavioral profile of CBD as a potential drug of abuse was evaluated in C57BL/6J mice.Reinforcing properties of CBD(15,30,and 60 mg/kg;i.p.)were assessed using the conditioned place preference(CPP)paradigm.Spontaneous withdrawal symptoms and motor activity in the open field were examined 12 h after the last CBD administration(30 mg/kg/12 h,i.p.,6 days).CBD plasma concentrations were measured at 2,4,8,12,and 24 h after the administration of CBD(30 mg/kg,i.p.).Furthermore,an oral CBD selfadministration paradigm(50 mg/kg;CBD water-soluble 1.2 mg/mL)was performed to evaluate whether this drug produced any effects on motivation compared with a non-reinforcing substance(water).We found that CBD failed to induce CPP,withdrawal symptoms,or altered motor behavior 12 h after its administration.At that time,only traces of CBD were detected,ensuring that the lack of alterations in somatic signs and locomotor activity was not due to residual drug in plasma.Interestingly,mice displayed similar motivation and consumption of CBD and water.Taken together,these results show that CBD lacks activity as a drug of abuse and should stimulate the development of the basic and clinical studies needed to elucidate its potential therapeutic use for the treatment of neuropsychiatric and drug use disorders. | Adrián Viudez-Martínez María S.García-Gutiérrez Juan Medrano-Relinque Carmen M.Navarrón Francisco Navarrete Jorge Manzanares | 2019 | Acta Pharmacologica Sinica2019，40，3： | 2 |
| 2 | The Distribution and Origin of Trace Elements in a UK Coal:the Importance of Pyrite显示文摘 | Spears D A Manzanares Papayanopous L I Booth C A | 1999 | Fuel1999，78，14： | 1 |
| 3 | On the im- plementation of security policies with adaptative encryption 显示文摘 | Manzanares A I Sierra C J M Marquez J T | 2006 | Computer Communications2006，29，2： | 1 |
| 4 | Learning strategies used by beginning and intermediate ESL students 显示文摘 | O' Malley J M Chamot A U Stewner - Manzanares G Kupper L and Russo R 1985 | 1985 | Language Learning1985，35，1： | 1 |
| 5 | Learning strategies used by beginning and intermediate ESL students 显示文摘 | OMalley J M Chamot A U Stewner - Manzanares G | 1985 | Language learning1985，35，1： | 1 |
| 6 | Water dissociation effects in ion transport through anionic exchange membranes with thin cationic exchange surface films显示文摘 | Ramirez P Manzanares J A Mafé S | 1991 | Ber Bunsenges Phys Chem1991，95，1： | 1 |
| 7 | Model for ion transport in bipolar membranes 显示文摘 | Mafé S Manzanares J A Ramirez P | 1990 | Pbys Rev A1990，42，10： | 1 |
| 8 | Tempera- ture effects on counterion binding to spherical polyelec- trolytes : the charge- discharge transition of lignosulfonate 显示文摘 | Mafe S Manzanares V A Kontturi A K | 1995 | Bioelectrochemistry and Bioenergetics1995，38，： | 1 |
| 9 | Rate constant for ion transfer in inhomogeneous media at the interface of immiscible electrolytes显示文摘 | Kontturi K Manzanares J A Murtomaki L | 1997 | Journal of Physical Chemistry B1997，101，10： | 1 |
| 10 | Production of fuel ethanol from steam- explosion pretreated olive tree pruning显示文摘 | Cristo' bal Cara a Encarnacio' n Ruiz a Mercedes Ballesteros b Paloma Manzanares b Ma Jose' Negro b Eulogio Castro a | 2007 | Fuel2007，5，8： | 1 |
| 11 | The increasing complexity of the Snail gene superfamily in metazoan evolution显示文摘 | Manzanares M Locascio A Nieto M A | 2001 | Trends Genet2001，17，4： | 1 |
| 12 | Optimizing liquid hot water pretreatment conditions to enhance sugar recovery from wheat straw for fuel-ethanol production 显示文摘 | Perez J A Ballesteros I Ballcsteros M Sdez F Negro M J Manzanares P | 2008 | Fuel2008，87，： | 1 |
| 13 | Air-coupled MUMPs capacitive micrornachined ultrasonic transducers with resonant cavities显示文摘 | MANZANARES A O ESP1NOSA F M | 2012 | Ultrasonics2012，52，： | 1 |
| 14 | Learning strategies used by beginning and intermediate ESL students 显示文摘 | O'MALLEY J M CHAMOT A U STEWNER- MANZANARES G | 1985 | Language Learning1985，35，1： | 1 |
| 15 | Biofilm growth and bed fluidization in a fluidized bed reactor packed with support materials of low density显示文摘 | Teran R A Saucedo Baca N Ramirez Papayanopoulos Manzanare L | 2004 | Eng Life Sci2004，4，2： | 1 |
| 16 | Improving the amylolytic activity of Saccharomyces cerevisiae glucoamylase by the addition of a starch binding domain 显示文摘 | LATORRE-GARCIA L ADAM A C MANZANARES P | 2005 | J Biotechnol2005，118，2： | 1 |
| 17 | Modelling the transport of carbonic acid anions through anion-exchange membranes显示文摘 | Nikonenko V Lebedev K Manzanares J A | 2003 | Electrochimica Acta2003，48，： | 1 |
| 18 | EAD and PEBD:two energy-aware duplication scheduling algorithms for parallel tasks on homogeneous clusters显示文摘 | ZONG Ziliang MANZANARES A RUAN Xiaojun | 2011 | IEEE Transactions on Computers2011，60，3： | 1 |
| 19 | Hyaluronic acid combined with mannitol to improve protection against free-radical endothelial damage:experimental model显示文摘 | BELDA J I ARTOAL A GARCA MANZANARES M D | 2005 | J Cataract Refract Surg2005，31，6： | 1 |
| 20 | Ion-exchange fibers and drugs: a transient study显示文摘 | VUORIO M MANZANARES J A MURTOMAKI L | 2003 | Journal of Controlled Release2003，91，3： | 1 |
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