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| 1 | Review of natural products with hepatoprotective effects显示文摘The liver is one of the most important organs in the body,performing a fundamental role in the regulationof diverse processes,among which the metabolism,secretion,storage,and detoxification of endogenous and exogenous substances are prominent.Due to these functions,hepatic diseases continue to be among the main threats to public health,and they remain problems throughout the world.Despite enormous advances in modern medicine,there are no completely effective drugs that stimulate hepatic function,that offer complete protection of the organ,or that help to regenerate hepatic cells.Thus,it is necessary to identify pharmaceutical alternatives for the treatment of liver diseases,with the aim of these alternatives being more effective and less toxic.The use of some plants and the consumption of different fruits have played basic roles in human health care,and diverse scientific investigations have indicated that,in those plants and fruits so identified,their beneficial effects can be attributed to the presence of chemical compounds that are called phytochemicals.The present review had as its objective the collecting of data based on research conducted into some fruits(grapefruit,cranberries,and grapes)and plants[cactus pear(nopal)and cactus pear fruit,chamomile,silymarin,and spirulina],which are consumed frequently by humans and which have demonstrated hepatoprotective capacity,as well as an analysis of a resin(propolis)and some phytochemicals extracted from fruits,plants,yeasts,and algae,which have been evaluated in different models of hepatotoxicity. | Eduardo Madrigal-Santillán Eduardo Madrigal-Bujaidar Isela álvarez-González María Teresa Sumaya-Martínez José Gutiérrez-Salinas Mirandeli Bautista ángel Morales-González Manuel García-Luna y González-Rubio J Leopoldo Aguilar-Faisal José A Morales-González | 2014 | World Journal of Gastroenterology2014，20，40： | 10 |
| 2 | Model for end-stage liver disease-Na score or Maddrey discrimination function index, which score is best?显示文摘AIM: To compare the ability of model for end-stage liver disease(MELD)-Na and Maddrey discrimination function index(DFI) to predict mortality at 30 and 90 d in patients with alcoholic hepatitis(AH).METHODS: We prospectively assessed 52 patients with AH. Demographic, clinical and laboratory parameters were obtained. MELD-Na and Maddrey DFI were calculated on admission. Short-term mortality was assessed at 30 and 90 d. Receiver operating characteristic curve analysis was performed. RESULTS: Thirty-day and 90-d mortality was 44% and 58%, respectively. In the univariate analysis, sodium levels was associated with mortality at 30 and 90 d(P = 0.001 and P = 0.03). Child stage, encephalopathy, ascites, or types of treatment were not associated with mortality. MELD-Na was the only predictive factor for mortality at 90 d. For 30-d mortality area under the curve(AUC) was 0.763(95%CI: 0.63-0.89) for Maddrey DFI and 0.784 for MELD-Na(95%CI: 0.65-0.91, P = 0.82). For 90-d mortality AUC was 0.685(95%CI: 0.54-0.83) for Maddrey DFI and 0.8710 for MELD-Na(95%CI: 0.76-0.97, P = 0.041). CONCLUSION: AH is associated with high shortterm mortality. Our results show that MELD-Na is a more valuable model than DFI to predict short-term mortality. | Mercedes Amieva-Balmori Scherezada María Isabel Mejia-Loza Roberto Ramos-González Felipe Zamarripa-Dorsey Eli García-Ruiz Nuria Pérez y López Eumir I Juárez-Valdés Adriana López-Luria José María Remes-Troche | 2015 | World Journal of Hepatology2015，7，17： | 2 |
| 3 | Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation显示文摘 | Jose A. Rodríguez-Navarro Laura Rodríguez María J. Casarejos Rosa M. Solano Ana Gómez Juan Perucho Ana María Cuervo Justo García de Yébenes María A. Mena | 2010 | Neurobiology of Disease2010，，3： | 2 |
| 4 | Application of Matrix Solid-phase Dispersion to the Determination of a New Generation of Fungicides in Fruits and Vegetables显示文摘 | Navarro M Picó Y Marín R | 2002 | Journal of Chromatography A2002，，968： | 1 |
| 5 | Evidence for differential cortical input to direct pathway versus indirect pathway striatal projection neurons in rats 显示文摘 | Lei W L Jiao Y Del Mar N | 2004 | J Neurosci2004，24，38： | 1 |
| 6 | Evidence for differential cortical input to direct pathway versus indirect pathway striatal projection neurons in rats显示文摘 | Lei WL Jiao Y Del Mar N | 2004 | J Neurosci2004，24，8： | 1 |
| 7 | Existence of Positive Solutions of a Fourth-order Boundary Value Problem显示文摘 | MAR Y | 2005 | Appl Math Comput2005，168，： | 1 |
| 8 | Evidence for differential cortical input to direct pathway versus indirect pathway striatal projection neurons in rats 显示文摘 | Lei WL Jiao Y Del Mar N | 2004 | J Neurosci2004，24，38： | 1 |
| 9 | Lois De Pertes De Charge Dans Les Conduits Karstiques: Base Th6orique Et Observations显示文摘 | Jeannin P Y Mar&hal J C | 1995 | Bulletin D'' Hydrog6- ologie De 1'' Universit6 De Neuchfitel1995，14，： | 1 |
| 10 | Computerized- tomography-guided percutaneous tumor ablation using acetic acid injection in an aldosterone producing tumor-- a novel therapy 显示文摘 | Liang H L Liang H L Mar G Y | 2000 | Zhonghua Yi Xue Za Zhi2000，63，11： | 1 |
| 11 | Multiplicity results for second-order two-point boundary value problems with superlinear or sublinear nonlinearities显示文摘 | MAR Y THOMPSON B | 2005 | Journal of Mathematical Analysis and Applications2005，303，2： | 1 |
| 12 | Retardation of polymer oxidation by natural antioxidant gossypol:Part 1-Kinetics of oxygen consumption显示文摘 | Mar'in A P Shlyapnikov Y A Mametov E S | 1992 | Polymer Degradation and Stability1992，35，2： | 1 |
| 13 | Nodal solutions for nonlinear eigenvalue problems显示文摘 | MAR Y THOMPSON B | 2004 | Nonlinear Analysis : Theory Methods & Applications2004，59，5： | 1 |
| 14 | Fast hadamard transform using the H diagram显示文摘 | Mar H Y Sheng C L | 1973 | IEEE Transactions on Computers1973，22，10： | 1 |
| 15 | Multiplicity of positive solutions for second order three point boundary value problem显示文摘 | MAR Y | 2001 | Comput Math Appl2001，40，： | 1 |
| 16 | Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model显示文摘 | Jin Y Atkinson SJ Mars JA | 2002 | Int J Cancer2002，98，： | 1 |
| 17 | High noise vehicle plate recognition using grey system显示文摘 | Hsu Y T Lin C B Mar S C | 1998 | The Journal of Grey System1998，10，3： | 1 |
| 18 | The protective role of inter- leukin-33 in myocardial ischemia and reperfusion is associat- ed with decreased HMGB1 expression and up-regulation ofthe P38 MAPK signaling pathway显示文摘 | MAR S ttU X R ttU G Y | 2015 | PLoS one2015，10，01： | 1 |
| 19 | Magnetic mi- crosphere-confined grapheme for the extraction of poly- cyclic aromatic hydrocarbons from environmental water samples coupled with high performance liquid chroma- tography-fluorescence analysis 显示文摘 | WANGWN MAR Y WU Q H | 2013 | Journal of Chroma- tography A2013，1293，： | 1 |
| 20 | Role of liver biopsy in the management of liver dysfunction after hematopoietic stem-cell transplantation in a hepatitis B virus-prevalent patient population显示文摘 | Mar S Y | | Transplantation0，76，1： | 1 |
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