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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 3 | Analysis of genomic rearrangement and subsequent gene deletion of the attenuated Orf virus strain D1701显示文摘 | Rosita Cottone Mathias Büttner Berthilde Bauer Marco Henkel Eduard Hettich Hanns-Joachim Rziha | 1998 | Virus Research1998，，1： | 3 |
| 4 | High body mass index predicts multiple prostate cancer lymph node metastases after radical prostatectomy and extended pelvic lymph node dissection显示文摘Our aim is to evaluate the association between body mass index(BMI)and preoperative total testosterone(TT)levels with the risk of single and multiple metastatic lymph node invasion(LNI)in prostate cancer patients undergoing radical prostatectomy and extended pelvic lymph node dissection.Preoperative BMI,basal levels of TT,and prostate-specific antigen(PSA)were evaluated in 361 consecutive patients undergoing radical prostatectomy with extended pelvic lymph node dissection between 2014 and 2017・Patients were grouped into either nonmetastatic,one,or more than one metastatic lymph node invasion groups.The association among clinical factors and LNI was evaluated.LNI was detected in 52(14.4%)patients:28(7.8%)cases had one metastatic node and 24(6.6%)had more than one metastatic node.In the overall study population,BMI correlated inversely with TT(r=-0.256;P<0.0001).In patients without metastases,BMI inversely correlated with TT(r=-0.282;P<0.0001).In patients with metastasis,this correlation was lost.In the overall study population,BMI(odds ratio[OR]=1.268;P=0.005)was the only in dependent clinical factor associated with the risk of multiple metastatic LNI compared to cases with one metastatic node.In the nonmetastatic group,TT was lower in patients with BMI>28 kg m^2(P<0.0001).In patients with any LNI,this association was lost(P=0.232).The median number of positive nodes was higher in patients with BMI>28 kg m^2(P-0.048).In our study,overweight and obese patients had a higher risk of harboring multiple prostate cancer lymph node metastases and lower TT levels when compared to patients with normal BMI. | Antonio B Porcaro Alessandro Tafuri Marco Sebben Tania Processali Marco Pirozzi Nelia Amigoni Riccardo Rizzetto Aliasger Shakir Maria Angela Cerruto Matteo Brunelli Salvatore Siracusano Walter Artibani | 2020 | Asian Journal of Andrology2020，22，3： | 3 |
| 5 | Scholarly networks on resilience, vulnerability and adaptation within the human dimensions of global environmental change显示文摘 | Marco A. Janssen Michael L. Schoon Weimao Ke Katy B?rner | 2006 | Global Environmental Change2006，，3： | 2 |
| 6 | Mathematical simulation of radial heat transfer in packed beds by pseudohomogeneous modeling显示文摘Uniform flow regime and constant effective thermal conductivity inside packed beds are commonly accepted in the evaluation of the fluid dynamics and heat transfer in such systems.However,several authors have confirmed the presence of an oscillatory velocity profile caused by the effective contribution of porosity profile in the fluid dynamic behavior of packed beds,which directly influences the heat transfer inside the beds.This paper describes the application of a pseudo-homogeneous mathematical model for describing heat transfer in packed beds with oscillatory profiles of velocity and porosity,using a radius-dependent model for effective thermal conductivity k r.Several temperature profiles were obtained in a packed bed system with thermal source located on the wall.The simulated temperature and effective thermal conductivity obtained from simulations were compared with experimental data and calculation from a model based on uniform k r fitting.The results indicate that the proposed mathematical modeling was capable of better representing the heat transfer in the packed bed. | Rodrigo Béttega Marcos Flávio Pinto Moreira Ronaldo Guimaraes Corrêa José Teixeira Freire | 2011 | Particuology2011，9，2： | 2 |
| 7 | Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias显示文摘 | Steven L Higgins John D Hummel Imran K Niazi Michael C Giudici Seth J Worley Leslie A Saxon John P Boehmer Michael B Higginbotham Teresa De Marco Elyse Foster Patrick G Yong | 2003 | Journal of the American College of Cardiology2003，，8： | 2 |
| 8 | Immediate and late effects of chronic stress in the testes of prepubertal and adult rats显示文摘这研究的目的是在 prepubertal 和成年老鼠的睾丸上调查长期的应力的效果并且评估任何改变是否能被颠倒什么时候强调正式就职被结束。老鼠被分到八的 76 男性组织取决于处理的类型(控制或强调) ,应力在被开始的年龄(prepubertal 或成年人) ,和评估的时间(立即或迟了) 。压力刺激 6 个星期被申请。在最后压力刺激以后立即评估的强调 prepubertal 和成年老鼠分别地在 SP-I 和 SA-I 组被包括。迟了的 prepubertal (系统程序设计语言) 和成年人(柳安) 强调老鼠组织 6 个星期在最后压力刺激以后被评估。匹配年龄的老鼠被用作控制(CP-I, CA-I, CP-L,和 CA-L 组) 。到在 SP-I 组的老鼠的压力刺激的申请导致了身体重量和生精的小管直径减小。在 SA-I 组的老鼠也显示出几功能(睾丸激素水平和精子参数) 并且词法(阴囊的重量和生精的小管直径) 减小。在系统程序设计语言组的老鼠显示出增加的身体重量和 intertubular 分隔空间容量、绝对的密度和减少的管状的分隔空间容量的密度。在柳安组的老鼠介绍了仅仅减少的精子生存能力。压力刺激在所有学习组在老鼠支持了变化。成年老鼠的睾丸是长期的应力影响的大多数。然而,强调成年老鼠从阴囊的改变恢复了很好。 | Carina T Ribeiro Diogo B De Souza Waldemar S Costa Francisco J B Sampaio Marco A Pereira-Sampaio | 2018 | Asian Journal of Andrology2018，20，4： | 2 |
| 9 | Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis显示文摘 | Paolo Muratori Luigi Muratori Rodolfo Ferrari Fabio Cassani Giampaolo Bianchi Marco Lenzi Luis Rodrigo Antonio Linares Dolores Fuentes Francesco B Bianchi | 2003 | The American Journal of Gastroenterology2003，，2： | 2 |
| 10 | Development of a selective enzyme- linked immunosorbent assay for 1- naphthol- the major metabolite of carbaryl(1- naphthyl n- methylcarbamate)显示文摘 | Marco M P Hammock B D | 1994 | J Agric Food Chem1994，42，4： | 1 |
| 11 | Enrichment of tomato fruit with health -promoting anthocyanins by expression of select transcription factors 显示文摘 | Eugenio B Lucilla T Marco G | 2008 | Nature Biotechnology2008，26，11： | 1 |
| 12 | Bird communities as hioindicators: The focal species concept in agricultural land- scape 显示文摘 | Emilio P D Marco B Renato M | 2006 | Ecological Indicators2006，，6： | 1 |
| 13 | A simple and fast method for the determination of endo- and exo-cellulase activity in cellulase preparations using filter paper 显示文摘 | MARCOS H L S MARTINHO R ELBA P D S B | 2012 | Enzyme and Microbial Technology2012，51，1： | 1 |
| 14 | SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information 显示文摘 | Marco B Stefan B Andrew W | 2014 | Nucleic Acids Res2014，42，1： | 1 |
| 15 | Effects of selective alpha1- and alpha2- adrenergic blockade on coronary flow reserve after coronary stenting 显示文摘 | Gregorini L Marco J Farah B | 2002 | Circulation2002，106，23： | 1 |
| 16 | Functional effects of high clopi- dogrel maintenance dosing in patients with inadequate platelet inhibition on standard dose treatment显示文摘 | Dominick J Marco A Steven B | 2008 | Am J Cardiol2008，101，： | 1 |
| 17 | Biotransformation of α-,β-,γ-,and δ-Hexachlorocyclohexane Under Methanogenic Conditions显示文摘 | MIDDELDORP P J M MARCO J ZEHNDER A J B | 1996 | Environmental Science & Technology1996，30，7： | 1 |
| 18 | Topical application of capsaicin for treatment of oral neuropathic pain and trigeminal neuralgia显示文摘 | EPSTEIN J B MARCOE J H | 1994 | Oral Surg Oral Med Oral Pathol1994，77，2： | 1 |
| 19 | Pilomatricoma in childhood:a retrospective study from three European paediatric centres显示文摘 | CIGLIANO B BALTOGIANNIS N DE MARCO M | 2005 | Eur J Pediatr2005，164，11： | 1 |
| 20 | Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis:serum inflammatory biomarkers,clinical efficacy,and microbiological eradication显示文摘 | Francesco B Paolo T Marco M | 2013 | Ther Clin Risk Manag2013，9，4： | 1 |
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