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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Pediatric non-alcoholic steatohepatitis:The first report on the ultrastructure of hepatocyte mitochondria显示文摘AIM:To investigate the ultrastructure of abnormal hepatocyte mitochondria,including their cellular and hepatic zonal distribution,in bioptates in pediatric nonalcoholic steatohepatitis(NASH).METHODS:Ultrastructural investigations were conducted on biopsy liver specimens obtained from 10children(6 boys and 4 girls)aged 2-14 years with previously clinicopathologically diagnosed NASH.The disease was diagnosed if liver biopsy revealed steatosis,inflammation,ballooned hepatocytes,Mallory hyaline,or focal necrosis,varying degrees of fibrosis in the absence of clinical,serological,or histological findings of infectious liver diseases,autoimmune hepatitis,metabolic liver diseases,or celiac disease.For ultrastructural analysis,fresh small liver blocks(1 mm3 volume)were fixed in a solution containing 2%paraformaldehyde and 2.5%glutaraldehyde in 0.1 mol/L cacodylate buffer.The specimens were postfixed in osmium tetroxide,subsequently dehydrated through a graded series of ethanols and propylene oxide,and embedded in Epon812.The material was sectioned on a Reichert ultramicrotome to obtain semithin sections,which were stained with methylene blue in sodium borate.Ultrathin sections were contrasted with uranyl acetate and lead citrate,and examined using an Opton EM 900 transmission electron microscope.RESULTS:Ultrastructural analysis of bioptates obtained from children with non-alcoholic steatohepatitis revealed characteristic repetitive mitochondrial abnormalities within hepatocytes;mainly mitochondrial polymorphisms such as megamitochondria,loss of mitochondrial cristae,and the presence of linear crystalline inclusions within the mitochondrial matrix of an increased electron density.The crystalline inclusions were particularly evident within megamitochondria(MMC),which seemed to be distributed randomly both within the hepatic parenchymal cell and the zones of hepatic lobule,without special variations in abundance.The inclusions appeared as bundles viewed longitudinally,or as an evenly spaced matrix in cross section,and frequently caused mitochondrial deformation.The average diameter of these linear structures was 10 nm and the average space between them 20 nm.Sometimes enlarged intramitochondrial granules were seen in their vicinity.Foamy cytoplasm of hepatocytes was found,resulting from the proliferation of smooth endoplasmic reticulum and glycogen accumulation.The perivascular space of Disse was frequently dilated,and contained transitional hepatic stellate cells,as well as mature and/or newly forming collagen fiber bundles.CONCLUSION:Marked ultrastructural abnormalities observed in hepatocyte mitochondria,especially their polymorphism in the form of MMC and loss of mitochondrial cristae,accompanied by foamy cytoplasm,clearly indicate a major role of these organelles in the morphogenesis of pediatric NASH.Our findings seem to prove the high effectiveness of electron microscopy in the diagnosis of the disease. | Joanna M Lotowska Maria E Sobaniec-Lotowska Sylwia B Bockowska Dariusz M Lebensztejn | 2014 | World Journal of Gastroenterology2014，20，15： | 3 |
| 3 | Prognostic impact of the Bismuth-Corlette classification:Higher rates of local unresectability in stageⅢb hilar cholangiocarcinoma显示文摘Background:The Bismuth-Corlette(BC)classification is used to categorize hilar cholangiocarcinoma by proximal extension along the biliary tree.As the right hepatic artery crosses just behind the left bile duct,we hypothesized that BCⅢb tumors would have a higher likelihood of local unresectability due to involvement of the contralateral artery.Methods:A retrospective review of a prospectively maintained database identified patients with hilar cholangiocarcinoma taken to the operating room for intended curative resection between April 2008 and September 2016.Cases were assigned BC stages based on preoperative imaging.Results:Sixty-eight patients were included in the study.All underwent staging laparoscopy after which 16 cases were aborted for metastatic disease.Of the remaining 52 cases,14 cases were explored and aborted for locally advanced disease.Thirty-eight underwent attempt at curative resection.After exclud-ing cases aborted for metastatic disease,the chance of proceeding with resection was 55.6%for BCⅢb staged lesions compared to 80.0%of BCⅢa lesions and to 82.4%for BCⅠ-Ⅲa staged lesions(P<0.05).About 44.4%of BCⅢb lesions were aborted for locally advanced disease versus 17.6%of remaining BC stages.Conclusions:When hilar cholangiocarcinoma is preoperatively staged as BCⅢb,surgeons should antici-pate higher rates of locally unresectable disease,likely involving the right hepatic artery. | Michael J Passeri Maria R Baimas-George Jesse K Sulzer David A Iannitti John B Martinie Erin H Baker Lee M Ocuin Dionisios Vrochides | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 3 |
| 4 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 5 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 6 | Quantification of Listeria monoeytogenes in minimally processed leafy vegetables using a combined method based on enrichment and 16SrRNAreal-time PCR显示文摘 | Maria A O Eliana G R Alzira M B | 2010 | Food Microbiology2010，，27： | 1 |
| 7 | Bioactive Triterpene Derivatives from Latex of Two Euphorbia Species显示文摘 | NOUREDDINE M AHMED B MARIA B | 2008 | Phytochemistry2008，69，： | 1 |
| 8 | Development of a biosensor microarray towards food screening using imaging surface plasmon resonance 显示文摘 | SABINA R R MARIA G B GIESBERS M | 2008 | Biosensors and Bioelectronics2008，24，： | 1 |
| 9 | Activated carbons developed from surplus sludge for the removal of dyes from dilute aqueous solutions 显示文摘 | Maria J M Adriana A M Dolors B | 2003 | Chemical Engineering Journal2003，94，： | 1 |
| 10 | MCM41 functionalized with ethylenediaminetriacetic acid for ion-exchange chromatography 显示文摘 | Maria C B Corrado S Anna M T | 2011 | Journal of Materials Chemistry2011，21，： | 1 |
| 11 | Alternative nuclear functions for NF-KB family members显示文摘 | Llufs E Anna B Maria C M | 2011 | Am J Cancer Res2011，1，4： | 1 |
| 12 | Statistical interpretation of the color parameters of red wines in function of their phenolic composition during aging in bottle显示文摘 | Maria M Pedro J M Begona B | 2006 | European Food Research Technolozv2006，222，： | 1 |
| 13 | Biological Response Modifier Activity of an Exopolysaccharide from Paenibacillus jamilae CP-7显示文摘 | Alfonso R B Maria J V Encarnacion M | 2001 | Clinical and Diagnostic Laboratory Immunology2001，8，4： | 1 |
| 14 | Ozonated water extends the shelf life of fresh-cut lettuce显示文摘 | DAVID B MARIA V S ALICIA M | 2005 | J Agric Food Chem2005，53，14： | 1 |
| 15 | Ef'fcl of phospholipid composition and phase on nanodisc fihns al the solid-liquid interface as studied by neutron reilectivity显示文摘 | Maria W Robert B Kell M el al | 2013 | Langmuir2013，29，9： | 1 |
| 16 | Capillary e- lectrophoresis of free fatty acids by Indirect ultraviolet detection: application to the classification of vegetable oils according to their botanical origin显示文摘 | Maria V B Aar6n E D Jests L G M | 2011 | Food Chem- istry2011，59，10： | 1 |
| 17 | The relationship between nucleoside triphosphate hydrolase ( NTPase ) isoform and Toxoplasma strain virulence in rat and human toxoplasmosis显示文摘 | Johnson M Kevin B Maria CA | 2003 | Microbes and Infection2003，5，： | 1 |
| 18 | Simple Accurate Expressions for Planar Spiral Inductances显示文摘 | Sunderarajan S M Maria M H Stephen P B | 1999 | IEEE Journal of Soild-state Circuits1999，34，10： | 1 |
| 19 | Trends in hydrological parameters of a southern Brazilian watershed and its relation to human induced changes 显示文摘 | JORGE M M GIAMPAOLO Q P MARIA V B | 1998 | Water Resources Management1998，12，4： | 1 |
| 20 | Characterisation of low-fat high-dietary fibre frankfurters显示文摘 | NURIA G M MARIA 1 A A OLGA M B | 1999 | Meat Science1999，52，： | 1 |
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