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| 1 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 2 | Rice Drying,Storage and Processing:Effects of Post-Harvest Operations on Grain Quality显示文摘Various post-harvest processes of rice are commonly employed,especially during the off-season,to ensure its consumption feasibility,which often affect the grain quality.Different forms of drying,storage and processing of rice are evaluated to identify their effects on grain quality.Microwave drying has emerged as an alternative to the widely-used intermittent-drying and fixed-bed-dryer methods of drying paddy rice.Control of drying-air temperatures(between 40℃ and 60℃)according to the rice variety can improve quality,especially for exotic varieties.Keeping stored grain in hygroscopic balance,with water content between 11%to 15%,at temperatures between 16℃ and 20℃ and with intergranular relative humidity near 60%,allows 12 months of storage in a controlled environment without significant deterioration.Other innovations,notably the application of artificial refrigeration to grain stored in bulk in vertical cylindrical silos and the use of impermeable packaging for storage,ensure the conservation of grain mass.The different stages and equipments used to obtain polished,brown and parboiled rice result in significant changes in the nutritional value of rice because of the removal of the outermost layers of the grains.Polishing reduces the nutritional value and physical homogeneity of rice.Brown rice retains more bioactive compounds and nutrients because it does not lose the outer layer of the grains in the polishing processes.Parboiled rice,although less nutritious than brown rice,has better grain integrity and milling yield and less loss of nutrients than white rice. | Amanda MÜLLER Marcela Trojahn NUNES Vanessa MALDANER Paulo Carteri CORADI Rosana Santos de MORAES Samuel MARTENS Andressa Fernandes LEAL Vladison Fogliato PEREIRA Cristielle König MARIN | 2022 | Rice science2022，29，1： | 3 |
| 3 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 4 | Long-term cardiovascular outcomes in men with obstructive sleep apnea hypopnea with or without treatment with continuous positive airway pressure: an observational study显示文摘 | MARIN J M CARRIZO S J VICENTE E | 2005 | Lancet2005，365，： | 1 |
| 5 | Aortic root dilatation in young men with normally functioning bicuspid aortic valves 显示文摘 | Nistri S Sorbo MD Marin M | 1999 | Heart1999，82，2： | 1 |
| 6 | Normal Spinal Bone Marrow in Adult:Dynamic Gadolinium-enhanced MR Imaging显示文摘 | Jean M Marine D Eric L | 2003 | Radiology2003，229，： | 1 |
| 7 | Determination of adipate plasticizers in poly(vinyl chloride) by microwave- assisted extraction 显示文摘 | J M Cano M L Marin A Sanchez | 2002 | Journal of Chromatography A2002，963，： | 1 |
| 8 | Multiplex PCR assay for the identification and differentiation of all Brucella species and the vaccine strains BruceUa abortus S19 and RBS1 and Brucella melitensis Revl显示文摘 | Garcia Y D Marin C M de Miguel M J | | 0，，04： | 1 |
| 9 | Phosphorus clusters:synthesis in the gas-phase and possible cagelike and chain structures显示文摘 | Bulgakov A V Bobrenok O F Kosyakov V I Pzerov I Marine W Hed~n M Rohmund F Campbell E E B | | 0，，： | 1 |
| 10 | Role of universal 16S rRNA gene PCR and sequencing in diagnosis of prosthetic joint infection显示文摘 | Marin M Garcia-Lechuz JM Alonso P | 2012 | J Clin Microbiol2012，50，3： | 1 |
| 11 | Long-term cardiovascular outcomes in men with ob- structive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure an observational study显示文摘 | MARIN J M CARRIZO S J VICENTE E | 2005 | Lancet2005，365，： | 1 |
| 12 | Varicella prevention in the United States: A review of successes and challenges 显示文摘 | MARIN M MEISSNER HC SEWARD JF | 2008 | Pediatrics2008，122，3： | 1 |
| 13 | Boron removal by the duckweed Lemna gibba : A potential method for the remediation of boron-pol- luted waters显示文摘 | MARIN C M D ORON G | 2007 | Water Research2007，41，： | 1 |
| 14 | Behavioral and neuroendocrine effects of the exposure to chronic restraint or variable stress in early adolescent rats显示文摘 | CRUZ F C MARIN M T LE ~O R M | 2012 | International Journal of Developmental Neuroscience2012，30，1： | 1 |
| 15 | Influence of Thermal Conditions on the Combustion Synthesis of Si2N2O Phase显示文摘 | Pradeilles N Record M C Marin A R M | 2008 | Materials Research Bulletion2008，43，： | 1 |
| 16 | P73 is a human p53-related protein that can induce apoptosis 显示文摘 | Marin M Kaelin WG | 1997 | Nature1997，389，2： | 1 |
| 17 | Afamily with a milder formofadultdominant polycystic kidney disease not linked to the PKD1 (16p) orPKD2(4q) genes显示文摘 | ALVAREZ V MARIN R | 1997 | J Med Genet1997，34，4： | 1 |
| 18 | Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment显示文摘 | Rodfigues C M Marin J G Brites D | 1999 | Gut1999，45，3： | 1 |
| 19 | Studies on the origin of microorganisms multiplying during manufacture of dry cured raw ham显示文摘 | CORNEJO I CARRASCOSA A V MARIN M E | 1992 | Fleischwirtschaft1992，72，10： | 1 |
| 20 | Ethanol affects calmodulin and the calmodulin-binding proteins neuronal nitric oxide synthase and aII spectrin(a-fodrin) in the nucleus of growing and differentiated rat astrocytes in pri mary cuhure显示文摘 | Tomas M Marin MP Protoles M | 2007 | Toxicol Vitro2007，21，： | 1 |
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