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| 1 | Upper gastrointestinal tract capsule endoscopy using a nurse-led protocol: First reported experience显示文摘AIM To test the feasibility and performance of a novel upper gastrointestinal(GI) capsule endoscope using a nurse-led protocol. METHODS We conducted a prospective cohort analysis of patients who declined gastroscopy(oesophagogastroduodenoscopy, OGD) but who consented to upper GI capsule endoscopy. Patients swallowed the upper GI capsule following ingestion of 1 liter of water(containing simethicone). A series of positional changes were used to exploit the effects of water flow and move the upper GI capsule from one gravity-dependent area to another using a nurse-led protocol. Capsule transit time, video reading time, mucosal visualisation, pathology detection and patient tolerance was evaluated.RESULTS Fifty patients were included in the study. The mean capsule transit times in the oesophagus and stomach were 28 s and 68 min respectively. Visualisation of the following major anatomical landmarks was achieved(graded 1-5: Poor to excellent): Oesophagus, 4.8(± 0.5); gastro-oesophageal junction(GOJ), 4.8(± 0.8); cardia, 4.8(± 0.8); fundus, 3.8(± 1.2); body, 4.5(± 1); antrum, 4.5(± 1); pylorus, 4.7(± 0.8); duodenal bulb, 4.7(± 0.7); second part of the duodenum(D2), 4.7(± 1). The upper GI capsule reached D2 in 64% of patients. The mean video reading time was 48 min with standard playback mode and 20 min using Quickview(P = 0.0001). No pathology was missed using Quickview. Procedural tolerance was excellent. No complications were seen with the upper GI capsule. CONCLUSION The upper GI capsule achieved excellent views of the upper GI tract. Future studies should compare the diagnostic accuracy between upper GI capsule and OGD. | Hey-Long Ching Ailish Healy Victoria Thurston Melissa F Hale Reena Sidhu Mark E McAlindon | 2018 | World Journal of Gastroenterology2018，24，26： | 9 |
| 2 | Capsule endoscopy:Current practice and future directions显示文摘Capsule endoscopy(CE)has transformed investigation of the small bowel providing a non-invasive,well tolerated means of accurately visualising the distal duodenum,jejunum and ileum.Since the introduction of small bowel CE thirteen years ago a high volume of literature on indications,diagnostic yields and safety profile has been presented.Inclusion in national and international guidelines has placed small bowel capsule endoscopy at the forefront of investigation into suspected diseases of the small bowel.Most commonly,small bowel CE is used in patients with suspected bleeding or to identify evidence of active Crohn’s disease(CD)(in patients with or without a prior history of CD).Typically,CE is undertaken after upper and lower gastrointestinal flexible endoscopy has failed to identify a diagnosis.Small bowel radiology or a patency capsule test should be considered prior to CE in those at high risk of strictures(such as patients known to have CD or presenting with obstructive symptoms)to reduce the risk of capsule retention.CE also has a role in patients with coeliac disease,suspected small bowel tumours and other small bowel disorders.Since the advent of small bowel CE,dedicated oesophageal and colon capsule endoscopes have expanded the fields of application to include the investigation of upper and lower gastrointestinal disorders.Oesophageal CE may be used to diagnose oesophagitis,Barrett’s oesophagus and varices but reliability in identifying gastroduodenal pathology is unknown and it does not have biopsy capability.Colon CE provides an alternative to conventional colonoscopy for symptomatic patients,while a possible role in colorectal cancer screening is a fascinating prospect.Current research is already addressing the possibility of controlling capsule movement and developing capsules which allow tissue sampling and the administration of therapy. | Melissa F Hale Reena Sidhu Mark E McAlindon | 2014 | World Journal of Gastroenterology2014，20，24： | 9 |
| 3 | A multibit E A modulator in floating-body SOS/SOI CMOS for extreme radiation environments显示文摘 | CHRISTOPHER F E WILLIAM R W MARK B | 1999 | IEEE J of Solid State Circuits1999，34，7： | 1 |
| 4 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 5 | Anisotropic effects on the strain rate dependence of a wrought magnesium alloy 显示文摘 | MATTHEW T T MARK F H PHILLIP M G HAITHAM E K WILBURN R W | 2009 | Scripta Materialia2009，60，： | 1 |
| 6 | The effects of land-uso history on soil properties and nutrient dynamics in northern hardwood forests of the ad- irondack mountains 显示文摘 | Larry E F Canham C D Marks P L | 2004 | Ecosystems2004，7，2： | 1 |
| 7 | The Risk of Catheter-related Bloodstream Infection with Femoral Venous Catheters asCompared to Subclavian and Internal Jugular Venous Catheters: A Systematic Review of the Literature and Meta- analysis显示文摘 | Marik P E Mark F Wendy H | 2012 | Critical Care Medicine2012，40，8： | 1 |
| 8 | Navy shipboard time synchronization service options and analysis 显示文摘 | GLASS Mark E O'DONOGHUE Karen F | 2008 | IEEE Computer and Information Science2008，46，： | 1 |
| 9 | Cellulase for commodity products from cellulosic biomass显示文摘 | Michael E H Mark F R Charles E | 1999 | Current Opinion in Biotechnology1999，10，4： | 1 |
| 10 | Bayesian stochastic frontier a- nalysis using WinBUGS 显示文摘 | JIM E GRIFFIN MARK F J STEEL | 2007 | Journal of Productivity Analysis2007，27，5： | 1 |
| 11 | Fault-tolerant control performance comparison of three and five-phase PMSG for marine current turbine applications显示文摘 | Mark F Ben Elghali S Benbouzid M E H | 2014 | IEEE Transactions on Sustainable Energy2014，50，11： | 1 |
| 12 | Kalman filtering for attitude estimation显示文摘 | Lefferta E J Markely F L Shuster M D | 1982 | Journal of Guidance Control and Dynamics1982，5，5： | 1 |
| 13 | Degradation of explosives-related compounds using nickel catalysts显示文摘 | MARK E F CHARLES E S JEAN M L | 2007 | Chemosphere2007，，67： | 1 |
| 14 | Dose-response analysis for nasopharyngeal carcinoma:a historical perspective显示文摘 | Marks J E Bedwinek J M Lee F | 1982 | Cancer1982，50，6： | 1 |
| 15 | Stationary and moving convective bands in hurricanes显示文摘 | Willoughby H E Marks F D Jr Feinberg R J | | 0，，22： | 1 |
| 16 | Synthesis and initial SAR studies of 3, 6-disubstituted pyrazolo pyrimidines: A new class of KDR kinase inhibitors 显示文摘 | MARK E F WILLIAM F H ROBERT S R | 2002 | Bicorg Med Chem Lett2002，12，19： | 1 |
| 17 | Visualization of the distal intratemporal facial nerve with MR imaging: use of an oblique plane显示文摘 | Mark L P Yetkin F Z Hendrix L E | 1992 | Radiology1992，182，： | 1 |
| 18 | Effects on Carbon Storage of Conversion of Old-growth Forests to Young Forests显示文摘 | William K Ferrell Jerry F Franklin | 1990 | Science1990，247，4943： | 1 |
| 19 | Inlejrating oxalate dexensitizers with total- each two- step adhesive 显示文摘 | TAY F R PASHLEY D H MARK Y E | 2003 | J Dentres2003，82，9： | 1 |
| 20 | A Randomized Trial of Calcium Supplementation for Childhood Lead Poisoning 显示文摘 | Morri E Markowitz MD Mark Sinnett PharmD John F & Rosen MD | 2004 | PEDIATRICS2004，113，2： | 1 |
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