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| 1 | Low rates of adherence for tumor necrosis factor-α inhibitors in Crohn's disease and rheumatoid arthritis: Results of a systematic review显示文摘AIM:To investigate adherence rates in tumor necrosis factor-α (TNF-α)-inhibitors in Crohn's disease (CD) and rheumatoid arthritis (RA) by systematic review of medical literature. METHODS:A structured search of PubMed between 2001 and 2011 was conducted to identify publications that assessed treatment with TNF-α inhibitors providing data about adherence in CD and RA. Therapeutic agents of interest where adalimumab, infliximab and etanercept, since these are most commonly used for both diseases. Studies assessing only drug survival or continuation rates were excluded. Data describing adherence with TNF-α inhibitors were extracted for each selected study. Given the large variation between definitions of measurement of adherence, the definitions as used by the authors where used in our calculations. Data were tabulated and also presented descriptively. Sample size-weighted pooled proportions of patients adherent to therapy and their 95%CI were calculated.To compare adherence between infliximab, adalimumab and etanercept, the adherence rates where graphed alongside two axes. Possible determinants of adherence were extracted from the selected studies and tabulated using the presented OR. RESULTS:Three studies on CD and three on RA were identified, involving a total of 8147 patients (953 CD and 7194 RA). We identified considerable variation in the definitions and methodologies of measuring adherence between studies. The calculated overall sample size-weighted pooled proportion for adherence to TNF-α inhibitors in CD was 70% (95%CI:67%-73%) and 59% in RA (95%CI:58%-60%). In CD the adherence rate for infliximab (72%) was highercompared to adalimumab (55%), with a relative risk of 1.61 (95%CI:1.27-2.03), whereas in RA adherence for adalimumab (67%) was higher compared to both infliximab (48%) and etanercept (59%), with a relative risk of 1.41 (95%CI:1.3-1.52) and 1.13 (95%CI:1.10-1.18) respectively. In comparative studies in RA adherence to infliximab was better than etanercept and etanercept did better than adalimumab. In three studies, the most consistent factor associated with lower adherence was female gender. Results for age, immunomodulator use and prior TNF-α inhibitors use were conflicting. CONCLUSION:One-third of both CD and RA patients treated with TNF-α inhibitors are non-adherent. Female gender was consistently identified as a negative determinant of adherence. | Herma H Fidder Maartje MJ Singendonk Mike van der Have Bas Oldenburg Martijn GH van Oijen | 2013 | World Journal of Gastroenterology2013，19，27： | 2 |
| 2 | Abdominosacral resection for priary irresectable and locally recurrent rectal cancer 显示文摘 | Mannaerts GH Rutten H J Martijn H | 2001 | Dis Colon Rectum2001，44，6： | 1 |
| 3 | Overcoming ego depletion: The influence of exemplar priming on self-control performance显示文摘 | MARTIJN C ALBERTS H J E M MERCKELBACH H | 2007 | Euro J Soc Psychol2007，37，： | 1 |
| 4 | Radiotherapy for locoregional relapses of rectal carcinoma after initial radical surgery: definite but limited influence on relapse- free survival and survival显示文摘 | Lybeert ML Martijn H De Neve W | 1992 | Int J Radiat Oncol Biol Phys1992，24，2： | 1 |
| 5 | Genetic characterization of type 2 porcine circovirus(PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential Pck-restriction fragment lenth polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2显示文摘 | Martijn F Patrick G H Mike G | 2000 | J Clin Microbiol2000，38，7： | 1 |
| 6 | Radicality of resection and survival after multimodality treatment is influenced by subsite of locally recurrent rectal cancer显示文摘 | Kusters M Dresen RC Martijn H | | 0，，： | 1 |
| 7 | Overcoming ego depletion: The influence of exemplar priming on self-control performance 显示文摘 | MARTIJN C ALBERTS H J E M MERCKELBACH H | 2007 | Eur J Soc Psychol2007，37，2： | 1 |
| 8 | Fighting self-control failure:Overcoming ego depletion by increasing self-awareness显示文摘 | Alberts H J Martijn G Vries N K | | 0，，： | 1 |
| 9 | Review of Organic Ran- kine Cycle (ORC) Architectures for Waste Heat Recovery显示文摘 | Steven L Henk H Martijn B | 2015 | RenewSustEnergRev2015，47，： | 1 |
| 10 | Radical resection after IORT-containing multimodality treatment is the most important determinant for outcome in patients treated for locally recurrent rectal cancer显示文摘 | Dresen RC Gosens MJ Martijn H | | 0，，： | 1 |
| 11 | Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis显示文摘 | Richard P G ten Broek Martijn W J Stommel Chema Strik Cornelis J H M van Laarhoven Frederik Keus Harry van Goor | 2014 | The Lancet2014，，9911： | 1 |
| 12 | Photodynamic therapy in oncology 显示文摘 | Martijn T Paul B Schellens J H M | 2006 | Oncologist2006，11，9： | 1 |
| 13 | Genetic characterization of type 2 porcine circovirus(PCV-2) from pigs with postweaning multisystemic wasting syndrome in different geographic regions of North America and development of a differential PCK-restriction fragment length polymorphism assay to detect and differentiate between infections with PCV-1 and PCV-2显示文摘 | Martijn F Patriek G H Mike G | 2000 | J Clin Microbiol2000，38，7： | 1 |
| 14 | Comparison of intraoperative radiation therapy-containing multimodality treatment with historical treatment modalities for locally recurrent rectal cancer 显示文摘 | Mannaerts GH Rutten H J Martijn H | 2001 | Dis Colon Rectum2001，44，12： | 1 |
| 15 | Radical resec- tion after IORT-containing multimodality treatment is the mostimportant determinant for outcome in patients treated for locally recurrent rectal cancer 显示文摘 | Dresen RC Gosens M J Martijn H | 2008 | Ann Surg Oncol2008，15，7： | 1 |
| 16 | Radical resection after IORT-containing muhimodality treatment is the most important determinant for outcome in patients treated for locally recurrent rectal cancer显示文摘 | Dresen RC Gosens MJ Martijn H | 2008 | Ann Surg Oncol2008，15，7： | 1 |
| 17 | Genetic characterization of type 2 porcine circovirus (PCV2) from pigs with postweaning muhisystemic wasting syndrome in different geographic regions of North America and development of a differential restriction fragment lenth polymorphism assay to detect and differentiate between infections with PCV1 and PCV2 显示文摘 | MARTIJN F PATRICK G H MIKE G | 2000 | J Clin Mierobiol2000，38，7： | 1 |
| 18 | Radiotherapy for locoregional relapses of rectal carcinoma after initial radical surgery:definite but limited influence on relapse-free survival and survival显示文摘 | Lybeert ML Martijn H De Neve W | 1992 | Int J Radiat Oncol Biol Phys1992，24，2： | 1 |
| 19 | Radical resection after IORT-containing multimodality treatment is the most important determinant for outcome in patients treated for locally recurrent rectal cancer显示文摘 | Dresen RC Gosens MJ Martijn H | 2008 | Ann Surg Oncol2008，15，7： | 1 |
| 20 | Patterns of local recurrence in locally advanced rectal cancer after intra-operative radiotherapy containing multimodality treatment显示文摘 | Kusters M Holman FA Martijn H | 2009 | Radiother Oncol2009，92，2： | 1 |
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