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| 1 | 一项在欧洲和中国进行的新型胃泌素释放肽前体(ProGRP)免疫检测多中心评估研究显示文摘背景在欧洲和中国进行Elecsys?胃泌素释放肽前体(ProGRP)免疫检测的多中心评估研究。方法在欧洲的3个中心和中国的2个中心,在肺癌中,通过不精密度、稳定性、方法学比较和鉴别诊断能力来评价该检测法。结果 5个分析物浓度的中间不精密度范围为变异系数:2.2%-6.0%。在不同储存条件下,血浆和血清样本均显示出良好的稳定性。在血浆中Elecsys?和ARCHITECT检测(斜率1.02,截距-2.72 pg/m L)之间表现出良好的相关性。同时,Elecsys?检测在血清和血浆样本之间表现出良好的相关性(斜率0.93,截距2.35 pg/m L;相关系数0.97)。ProGRP作为不受种族、年龄、性别或吸烟史相关影响的检测手段,可鉴别小细胞和非小细胞肺癌(NSCLC);截断值为84pg/m L时,曲线下面积为0.90,95%CI:0.87-0.93;敏感性为78.3%,特异性为95%。ProGRP浓度中位数在良性病变(38pg/m L)、其他恶性肿瘤(40 pg/m L)或NSCLC(39 pg/m L)中较低,而在3期以上慢性肾脏疾病中浓度较高(>100pg/m L)。结论 Elecsys?ProGRP检测在血清和血浆中稳定性增加,较现有检测法明显更具优势。ProGRP检测在中国的首次评价在不同种族中显示出相当的鉴别能力。 | Catharina M.KORSE Stefan HOLDENRIEDER Xiuyi ZHI Xiaotong ZAHNG Ling QIU Andrea GEISTANGER Marcus-Rene LISY Birgit WEHNL Daan van den BROEK José M.ESCUDERO Jens STANDOP Mu HU Rafael MOLINA | 2017 | 中国肺癌杂志2017，20，8： | 7 |
| 2 | Two‐Dimensional Si Nanosheets with Local Hexagonal Structure on a MoS2 Surface显示文摘 | Daniele Chiappe Emilio Scalise Eugenio Cinquanta Carlo Grazianetti Bas van den Broek Marco Fanciulli Michel Houssa Alessandro Molle | 2014 | Adv. Mater2014，，： | 7 |
| 3 | Vibrational properties of silicene and germanene显示文摘 | Emilio Scalise Michel Houssa Geoffrey Pourtois B. van den Broek Valery Afanas'ev andAndr Stesmans | 2013 | Nano Research2013，6，1： | 5 |
| 4 | Altered central pain processing after pancreatic surgery for chronic pancreatitis显示文摘 | S. A. Bouwense U. Ahmed Ali R. P. ten Broek Y. Issa C. H. van Eijck O. H. Wilder‐Smith H. van Goor | 2013 | Br J Surg2013，，13： | 3 |
| 5 | Virtual Liver Resection and Volumetric Analysis of the Future Liver Remnant using Open Source Image Processing Software显示文摘 | Joost R. Vorst Ronald M. Dam Rogier S. A. Stiphout Maartje A. den Broek Ilona H. Hollander Alfons G. H. Kessels Cornelis H. C. Dejong | 2010 | World Journal of Surgery2010，，10： | 2 |
| 6 | Topological to trivial insulating phase transition in stanene显示文摘stanene 的电子性质, graphene 的 Sn 对应物理论上用第一原则的模拟被学习。对一个 out-of-plane 电场或由量监禁效果导致的小绝缘阶段转变拓扑被预言。结果加亮潜力在门电压使用 stanene nanoribbons 控制了无驱散的基于纺纱的设备并且被用来将最小的 nanoribbon 宽度放为如此的设备,它典型地是约 5 nm。 | Michel Houssa Bas van den Broek Konstantina Iordanidou Anh Khoa Augustin Lu Geoffrey Pourtois Jean-Pierre Locquet Valery Afanas'ev Andre Stesmans | 2016 | Nano Research2016，9，3： | 2 |
| 7 | Endoscopic Trimodal Imaging Detects Colonic Neoplasia as Well as Standard Video Endoscopy显示文摘 | Teaco Kuiper Frank J.C. van den Broek Anton H. Naber Ellert J. van Soest Pieter Scholten Rosalie Ch. Mallant–Hent Jan van den Brande Jeroen M. Jansen Arnoud H.A.M. van Oijen Willem A. Marsman Jacques J.G.H.M. Bergman Paul Fockens Evelien Dekker | 2011 | Gastroenterology2011，，7： | 2 |
| 8 | Systematic review of endoscopic mucosal resection versus transanal endoscopic microsurgery for large rectal adenomas显示文摘 | R. Barendse F. van den Broek E. Dekker W. Bemelman E. de Graaf P. Fockens J. Reitsma | 2011 | Endoscopy2011，，11： | 2 |
| 9 | The role of High-Resolution Endoscopy and Narrow-Band Imaging in the evaluation of upper GI neoplasia in familial adenomatous polyposis显示文摘 | M. Lopez-Ceron F.J.C. van den Broek E.M. Mathus-Vliegen K.S. Boparai S. van Eeden P. Fockens E. Dekker | 2012 | Gastrointestinal Endoscopy2012，，： | 2 |
| 10 | Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy显示文摘Post-exposure prophylaxis(PEP)for leprosy is administered as one single dose of rifampicin(SDR)to the contacts of newly diagnosed leprosy patients.SDR reduces the risk of developing leprosy among contacts by around 60%in the first 2–3 years after receiving SDR.In countries where SDR is currently being implemented under routine programme conditions in defined areas,questions were raised by health authorities and professional bodies about the possible risk of inducing rifampicin resistance among the M.tuberculosis strains circulating in these areas.This issue has not been addressed in scientific literature to date.To produce an authoritative consensus statement about the risk that SDR would induce rifampicin-resistant tuberculosis,a meeting was convened with tuberculosis(TB)and leprosy experts.The experts carefully reviewed and discussed the available evidence regarding the mechanisms and risk factors for the development of(multi)drug-resistance in M.tuberculosis with a view to the special situation of the use of SDR as PEP for leprosy.They concluded that SDR given to contacts of leprosy patients,in the absence of symptoms of active TB,poses a negligible risk of generating resistance in M.tuberculosis in individuals and at the population level.Thus,the benefits of SDR prophylaxis in reducing the risk of developing leprosy in contacts of new leprosy patients far outweigh the risks of generating drug resistance in M.tuberculosis. | Liesbeth Mieras Richard Anthony Wim van Brakel Martin W.Bratschi Jacques van den Broek Emmanuelle Cambau Arielle Cavaliero Christa Kasang Geethal Perera Lee Reichman Jan Hendrik Richardus Paul Saunderson Peter Steinmann Wing Wai Yew | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 11 | A P-glycoprotein protects Caenorhabditis elegans against natural toxins 显示文摘 | BROEKS A JANSSEN H W CALAFAT J | 1995 | Embo J1995，14，9： | 1 |
| 12 | Chemokine receptor CCR2 is expressed by humar multiple myeloma cells and mediates migratin to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1,-2 and -3 显示文摘 | Broek IV Asossingh K Vanderkerken K | 2003 | Br J Cancer2003，88，6： | 1 |
| 13 | Atypical xanthomatosis in apolipoprotein E - deficient mice after cholesterol feeding显示文摘 | van Ree JH Gijbels MJJ van den Broek WJAA | 1995 | Atherosclerosis1995，112，2： | 1 |
| 14 | Cochlear implantation in children 显示文摘 | Van den Broek P Cohen N O' Donoghue | 1995 | Int J Pediatr Otorhinolaryngol1995，，： | 1 |
| 15 | Early versus late indomethacin treatment for patent ductus arteriosus in premature infants with respiratory distress syndrome显示文摘 | Van Overmeire B Van de Broek H Van Laer P | 2001 | J Pedlatr2001，138，2： | 1 |
| 16 | Thermodynamics of the stability of amorphous alloys of two transition metals 显示文摘 | COEHOORN R VAN DER KOLK G J VAN DEN BROEK J J MINEMURA T MIEDEMA A R | 1988 | J Less-Common Met1988，140，： | 1 |
| 17 | Review articleNew developments in colonic imaging 显示文摘 | Van den Broek FJ Fockens P Dekker E | 2007 | Aliment Pharmacol Ther2007，26，12： | 1 |
| 18 | Hair removal policies in clean surgery: systematic review of randomized, controlled trials 显示文摘 | NIEL-WEISE B S WILLE J C VAN DEN BROEK P J | 2005 | Infec Control Hosp Epidemiol2005，26，12： | 1 |
| 19 | Humidifi- cation policies for mechanically ventilated intensive care patients and prevention of ventilator-associated pneumo- nia: a systematic review of randomized controlled trials 显示文摘 | Nil-Weise B S Wille J C van den Broek P J | 2007 | J Hosp Infect2007，65，4： | 1 |
| 20 | Zinc exchange by blood cells in nearly physiologic standard conditions显示文摘 | Ton H. J. Naber Cornelis J. A. Hamer Wim J. M. Broek Hennie Roelofs | 1994 | Biological Trace Element Research (-)1994，，1： | 1 |
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