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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | MeSH pesticide trace analysis using solid-phase extraction and gas chromatography with electron capture and tandem mass spectrometric detection in water samples显示文摘 | Martinez Vidal J L Pablos Espada M C Garrido Frenich A | | Jounal of Chromatography A0，，： | 2 |
| 3 | Resistance to β-lactam/elavulanate resistance in Escherichia coli 显示文摘 | Martinez J L Cercenado E Rodriguez-Creixems M | 1987 | Lancet1987，2，8573： | 2 |
| 4 | Analytic relation between bulk moduli and lattice constants显示文摘 | Cohen M L Martinez G | 1987 | Phys Rev B1987，35，17： | 1 |
| 5 | Textural and physicochemical changes in salmon (Salmo salar) treated with commercial liquid smoke flavoudngs显示文摘 | MARTINEZ O SALMERON L GUILLEN M D | 2007 | Food Chemistry2007，100，2： | 1 |
| 6 | NF-Y and Sp1 are involved in transcriptional regulation of rat SND p102 gene显示文摘 | RODRIGUEZ L OCHOA B MARTINEZ M J | 2007 | Biochem Biophys Res Commun2007，356，1： | 1 |
| 7 | Computational prediction of novel components of lung transcription networks 显示文摘 | Martinez M J Smith A D Li B L | 2007 | Bioinformatics2007，23，1： | 1 |
| 8 | Landau level spectroscopy of ultrathin graphite layers显示文摘 | Sadowski M L Martinez G Potemski M | | 0，，26： | 1 |
| 9 | Detection of asymmetric giaucomatous damage using automated pupillography, the swinging flashlight method and the magnified-assisted swinging flashlight method 显示文摘 | WAISBOURD M LEE B ALI MH LU L MARTINEZ P FARIA B | 2015 | Eye (Lond)2015，29，10： | 1 |
| 10 | Evidence for Cu Ion Formation by Dissolution and Dealloying the Al2CuMg Intermetallic Compound in Rotating Ring--dish Collection Experiments 显示文摘 | BUCHHEIT R G MARTINEZ M A MONTES L P | 2000 | J of the Electrochemical Society2000，147，： | 1 |
| 11 | Abseislc acid in the response of Fortune mandarins to chilling: effect of maturity and high-temperature conditioning 显示文摘 | Lafuente M T Martinez T Zacarias L | 1997 | J SeiFoodAgrie1997，73，： | 1 |
| 12 | A New Method of Generating Differential GPS Corrections显示文摘 | Martinez J L Martinez M A Gareia-Cerezo A | 2000 | Control Engineering Practice2000，8，3： | 1 |
| 13 | Aluminium anodisation for Au-CeO2/Al2O3-AI monoliths preparation显示文摘 | Sanz O Martinez L M Echave F J | 2009 | Chemical Engineering Journal2009，151，13： | 1 |
| 14 | Structural studies of the polysaccharide isolated from Spondias purpurea gum exudate显示文摘 | PINTO G L D MARTINEZ M MENDOZA J A | 1996 | Carbohydr Res1996，290，： | 1 |
| 15 | Pga26 mediates filamentationand biofilm formation and is required for virulence in Candidaalbicans 显示文摘 | Laforet L Moreno I Sanchez-Fresneda R Martinez-Esparza M Martinez J P Argiielles J C | 2011 | FEMS Yeast Res2011，11，： | 1 |
| 16 | Hesperidin produces antinociceptive response and synergistic interaction with ketorolac in an arthritic gout-type pain in rats 显示文摘 | Martinez A L Gonzilez-Trujano M E Cbaivez M | 2011 | Pharmacology Biochemistry and Behavior2011，97，4： | 1 |
| 17 | Deletion or substi- tution of the aphthovirus 3r NCR abrogates infectivity and virus replieation显示文摘 | SAIZ M GOMEZ S MARTINEZ S E et a l | 2001 | J Gen Virol2001，82，1： | 1 |
| 18 | Elimination of pesticide residues from virgin olive oil by ultraviolet light: preliminary results 显示文摘 | Nieto Martinez L Hodaifa G Casanova M S | 2009 | Journal of Hazardous Materials2009，168，1： | 1 |
| 19 | 3D beamforming with ultrasonic divided ring arrays显示文摘 | ULLATE L G MARTINEZ O PARRILLA M | 2002 | Ultrasoincs2002，40，1： | 1 |
| 20 | Characterization of the entire cystatin gene family in barley and their target cathepsin L-like eysteine -proteases, partners in the hordein mobilization during seed germination 显示文摘 | MARTINEZ M CAMBRA I CARRILLO L | 2009 | Plant Physiology2009，151，3： | 1 |
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