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| 1 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 2 | Arkadia amplifies TGF-β superfamily signalling through degradation of Smad7 显示文摘 | Daizo K Masahiko A Akioshi K | 2003 | EMBO J2003，22，24： | 1 |
| 3 | Distribution of amylase,nitrogen,and minerals in rice kernels with various characters显示文摘 | TOMIO I MASAHIKO T EIKO A | 2003 | Agric Food Chem2003，54，： | 1 |
| 4 | Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm显示文摘 | Masahiko O Koichi Y Hiroki A | 2010 | Atherosclerosis2010，208，： | 1 |
| 5 | Removal of formaldehyde by activated carbons containing amino groups 显示文摘 | Sciki T Naohito K Takeo N Mamiko A Masahiko 1 | 1999 | Journal of Colloid and Interface Science1999，214，1： | 1 |
| 6 | Corrosion inhibition of carbon steel by molydbate-bdnzotriasole mixed inhibitor in concentrated lithium bromide solution at elevated temperature显示文摘 | Masahiko I Michihiko A Tanno K | 1987 | Boshoku Gijutsu1987，36，3： | 1 |
| 7 | Simuhaneous doping analysis of main urinary metabolites of anabolic steroids in horse by ion-trap gas chrtography-tandem mass spectrometry显示文摘 | Masayuki Y Sugako A Masahiko K | 2008 | Analytical Sciences2008，24，9： | 1 |
| 8 | Solubilization of Some Synthetic Perfumes by Anionic-nonionic Mixed Surfactant Systensl显示文摘 | Yoshikazu T Hirotaka U Masahiko A | 1995 | Langmuir1995，11，： | 1 |
| 9 | Solubilization of Some Synthetic Perfumes by Anionic-nonionic Mixed Surfactant Systensl 显示文摘 | Yoshikazu T Hirotaka U Masahiko A | 1994 | J Phys Chem1994，98，： | 1 |
| 10 | Guidelines for diagnosis and management of pediatric food allergy in Japan显示文摘 | Tokuko M Sankei N Masahiko A | | 0，，04： | 1 |
| 11 | Prognostic impact of ventlatory efficiency in heart disease patients with preserved exercise tolerance显示文摘 | Hideki T Hitoshi A Masahiko K | 2006 | Circ J2006，70，： | 1 |
| 12 | Predictive factors for interstitial lung disease, antitumor response, and survival in non small-cell lung cancer patients treated with Gefitinib显示文摘 | Masahiko A lsamu O Nobuyuki Y | 2006 | Journal of Clinical Oncology2006，24，16： | 1 |
| 13 | Gonad formation, sex differentiation gonad maturation processes in artificially pro- duced juveniles of the abalone, Haliotis discus lfannai 显示文摘 | MASAHIKO A KAORU H | 2004 | Aquaculture2004，239，： | 1 |
| 14 | Effect of Preparation Temperature on Cyclic CO2Captureand Multiple Carbonation-Calcination Cycles for a New Ca-Based CO2Sorbent显示文摘 | Masahiko A Toshiyuki N Junro M Yoichi N Haruhiko O | 2001 | Industial and Engineering ChemistryResearch2001，69，： | 1 |
| 15 | Synthesis of bismuth layer-structured ferroelectric particles by hydrothermal method and the fabrication of oriented ceramics 显示文摘 | Mitsutoshi K Masahiko K Akira A | 2004 | J Ceram Soc Jpn2004，112，5： | 1 |
| 16 | Synthesis and applications of surfactants containing fluorine显示文摘 | | 1999 | Colloid and Interface Science1999，4，： | 1 |
| 17 | Impact of pretreatment whole -tumor perfusion computed tomography and 18F -fluorodeoxyglucose positron emission tomography/computed tomography measurements on local control of non-small cell lung cancer treated with stereotactic body radiotherapy 显示文摘 | MASAHIKO A HIROYOSHI A MARIKO S | 2016 | J Radia Res2016，57，1： | 1 |
| 18 | Spontaneous vesicles formation from aqueous solution of didodecy ldimethy lammonium bromide and sodium dodecyl sulfate mixtures显示文摘 | Yukishige K Hirotaka U Masahiko A | 1995 | Langmuir1995，11，7： | 1 |
| 19 | The comparative effects of single intravenous doses of omeprazole and famotidine on intragastric PH 显示文摘 | Yasunobu A Masahiko L Jun Ichi T | 2004 | J Gastroenterol2004，39，1： | 1 |
| 20 | Significance of integrinα5 gene espression as a prognostic factor in node-negtive non-small lung cancer显示文摘 | TOSHIHIKO T MASAHIKO H | 2000 | Clin Cancer Res2000，6，1： | 1 |
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