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| 1 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 2 | Early recanalization and plasma brain natriuretic peptide as an indicator of left ventricular function after acute myocardial infarction显示文摘 | TERUO I MASASHI S ISAO Y | 2002 | Am Heart J2002，143，： | 1 |
| 3 | Electric double- layer capacitor composed of activated carbon fiber cloth electrodes and solid polymer electrolytes containing al- kylammonium salts 显示文摘 | Masashi I Masayuki M Mitsuo I | 1994 | J Electrochem Soc1994，141，7： | 1 |
| 4 | The clinical po- tential of pretreatment serum testosterone level to improve the efficiency of prostate cancer screening显示文摘 | Masashi Y Takashi I Hiroyoshi S | 2007 | Eur Urol2007，51，： | 1 |
| 5 | Effects of G-CSF on cardiac remodeling after acute myocardial infarction in swine显示文摘 | Koji I Hiroyuki T Masashi O | 2004 | Biochem Biophys Res Commun2004，325，4： | 1 |
| 6 | Functional screening using a microRNA virus library and microarrays:a new high-throughput assay to identify tumor-suppressive microRNAs显示文摘 | Masashi I Koji O Naoto T | 2010 | Carcinogenesis2010，31，8： | 1 |
| 7 | Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease A secretion 显示文摘 | Masashi A Nobuhisa I Ayumu Y | 2007 | Biochem Biophys Res Comm2007，352，： | 1 |
| 8 | Ionic association of lithium salts in propylene carbonate/1, 2-dimethoxyethane mixed systems for lithium batteries显示文摘 | Masashi I Shi Q W Yoshiharu M | 1993 | J Power Sources1993，45，2： | 1 |
| 9 | Periodic response of a rigid block resting on a footing subjected to harmonic excitation 显示文摘 | Kunihito M Masashi I Toshimi S | 1991 | Earthquake Engineering & Structural Dynamics1991，20，7： | 1 |
| 10 | Analytical expressions for three different modes in harmonic motion of sliding structures 显示文摘 | Masashi I Matsui K Kosaka I | 1992 | Earthquake Engineering & Structural Dynamics1992，21，9： | 1 |
| 11 | Serpentine locomotion with robotic snakes 显示文摘 | Masashi S Masakazu F Tetsuya I | 2002 | IEEE Control Systems Maga- zine2002，22，1： | 1 |
| 12 | 显示文摘 | Takashi K Wataru S Masashi I | 2002 | J Cardio2002，40，2： | 1 |
| 13 | Anhydrous protonconducting electrolyte membranes based on hyperbranched polymer with phosphonic acid groups for high-temperature fuel cells显示文摘 | Takahito I Keita H Masashi T | 2008 | Journal of Power Sources2008，，178： | 1 |
| 14 | Acetic aciddoped poly ( ethylene oxide) - modified poly ( methacrylate) :a new proton conducting polymeric gel dectrolyte 显示文摘 | Qiao J L Nobuko Y Masashi I | 2002 | Electrochim Acta2002，47，： | 1 |
| 15 | Synthesis of yttrium aluminum garnet by the glycothermal method显示文摘 | MASASHI I HIROYUKI O HIROSHI K TOMOYUKI I | 1991 | Journal of the American Ceramic Society1991，74，6： | 1 |
| 16 | Early recanalization and plasma brain natriuretic peptide as an indicator of left ventricular function after acute myocardial infarction 显示文摘 | Terou I Masashi S Isao Y | 2002 | Am Heart J2002，143，： | 1 |
| 17 | Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin 显示文摘 | Naoya T Masashi K Satoru I | 2006 | Am J Respir Cell Mol Biol2006，35，： | 1 |
| 18 | Behavior of Additives on the Coal Solubility and Aggregation 显示文摘 | CHEN Chong Masashi I | 1999 | Energy & Fuels1999，13，： | 1 |
| 19 | Early Recanalization and Plasma Brain Natriuretic Peptide as an Indicator of Left Ventricular Function after AMI 显示文摘 | Teruo I Masashi S Isao Y | 2002 | Am Heart J2002，143，： | 1 |
| 20 | Air-Stable n-Type Organic Field-Effect Transistors Based on Carbonyl-Bridged Bithiazole Derivatives显示文摘 | YUTAKA I MASASHI N MAKOTO K | 2010 | Adv Funct Mater2010，20，： | 1 |
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