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| 1 | New therapeutic options opened by the molecular classification of gastric cancer显示文摘Gastric cancer(GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with GC. | Mihaela Chivu-Economescu Lilia Matei Laura G Necula Denisa L Dragu Coralia Bleotu Carmen C Diaconu | 2018 | World Journal of Gastroenterology2018，24，18： | 14 |
| 2 | The effect of hy- poxia on gill morphology and ionoregulatory status in the Lake Qinghai scaleless carp, Gymnocypris przewalskii 显示文摘 | Matey V Richards J G Wang Y | 2008 | Journal of Experimental Biology2008，211，7： | 1 |
| 3 | Neuroendocrine differ- entiation in castration-resistant prostate cancer: a systematic diag- nostic attempt 显示文摘 | Matei DV Renne G Pimentel M | 2012 | Clin Genitourin Cancer2012，10，： | 1 |
| 4 | Neuroendocrine differentiation in castration-resistant prostate cancer: a systematic diagnostic attempt 显示文摘 | Matei DV Renne G Pimentel M | 2012 | Clin Genitourin Cancer2012，10，3： | 1 |
| 5 | Neuroendocrine dif- ferentiation in castration-resistant prostate cancer: a systematic diagnostic attempt显示文摘 | Matei DV Renne G Pientel M | 2012 | Clin Genitonrin Cancer2012，10，： | 1 |
| 6 | Sewflurane improves eleetrophysiologieal recovery of rat hippocampal slice CA1 pyramidal neurons 'after hypoxia显示文摘 | MATEI G PAVLIK R McCADDEN T et ol | 2002 | J Neurosurg Anesthesiol2002，14，4： | 1 |
| 7 | Neuroendocrine differentiation in castration-resistant prostate cancer: a systematic diagnostic attempt 显示文摘 | MATEI D V RENNE G PIMENTEL M | 2012 | Clin Genitourin Cancer2012，10，3： | 1 |
| 8 | Precision and accu- racy of thermal calibration of atomic force microscopy cantilevers 显示文摘 | MATEI G A THORESON E J PRATT J R | 2006 | Re- view of Scientific Instruments2006，77，08： | 1 |
| 9 | Sevoflurane improves electrophysiological recovery of rat hippocampal slice CA1 pyramidal neurons after hypoxia显示文摘 | Matei G Pavlik R Mccadden T | 2002 | J Neurosurg Anesthesiol2002，14，4： | 1 |
| 10 | Relationships between four measures of genetic distance and breeding behavior in spring wheat 显示文摘 | Benin G Matei G Oliveira A C | 2012 | Genetics and Molecular Research2012，11，3： | 1 |
| 11 | Activity of 2 methoxyestradinl (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritone carcinomatosis: a Hoosier Oncology Group trial 显示文摘 | Matei D Schilder J Sutton G | 2009 | Gynecol Oncol2009，115，1： | 1 |
| 12 | Sevoflurane improves elec- trophysiological recovery of rat hippocampal slice CA1 pyramidal neurons after hypoxia显示文摘 | Matei G Pavlik R Mccadden T | 2002 | J Neurosurg Anesthesiol2002，14，4： | 1 |
| 13 | Neuroendocrine differentiation in castration-resistant prostate cancer: a systematic diagnostic attempt 显示文摘 | Matei DV Renne G Pimentel M | 2012 | Chn (nitouin Cancer2012，10，： | 1 |
| 14 | Influence of electrolyte ion- solvent interactions on the performances of supercapacitors porous carbon electrodes 显示文摘 | Decaux C Matei G C Dahbi M | 2014 | J Power Sources2014，263，： | 1 |
| 15 | The effect of hypoxia on gill morphology and ionoregulatory status in the Lake Qinghai scaleless carp, Gymnocypris przewalskii 显示文摘 | Matey V Richards J G Wang Y | 2008 | The Journal of Experimental Biology2008，211，： | 1 |
| 16 | Behavior of hydrophobic isotopic exchange catalysts in the presence of tritiated water显示文摘 | POSTOLACHE C MATEI L IONITA G | 2005 | Fusion Science and Technology2005，48，： | 1 |
| 17 | The effect of hy- poxia on gill morphology and ionoregulatory status in the Lake Qinghai scaleless carp,Gymnocypris przew- alskii 显示文摘 | Matey V Richards J G Wang Y X | 2008 | Journal of' Experimental Biology2008，211，7： | 1 |
| 18 | Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through Met显示文摘 | Peinado H Alec?kovic′M Lavotshkin S Matei I Costa-Silva B Moreno-Bueno G | 2012 | Nat Med2012，18，6： | 1 |
| 19 | Passively synchronized erbium (1550 nm) and ytterbium (1040 nm) mode-locked fiber lasers sharing a cavity显示文摘 | Matei Rusu Robert Herda Oleg G | 2004 | Optics Letters2004，29，： | 1 |
| 20 | Gastrointestinal cancer stem cells as targets for innovative immunotherapy显示文摘The role of cancer stem cells in gastrointestinal cancer-associated death has been widely recognized.Gastrointestinal cancer stem cells(GCSCs)are considered to be responsible for tumor initiation,growth,resistance to cytotoxic therapies,recurrence and metastasis due to their unique properties.These properties make the current therapeutic trials against GCSCs ineffective.Moreover,recent studies have shown that targeting stem cell surface markers or stemness associated pathways might have an additional off-target effect on the immune system.Recent advances in oncology and precision medicine have opened alternative therapeutic strategies in the form of cancer immunotherapy.This approach differs from classical anti-cancer therapy through its mechanism of action involving the activation and use of a functional immune system against tumor cells,instead of aiming physically destruction of cancer cells through radio-or chemotherapy.New immunological approaches for GCSCs targeting involve the use of different immune cells and various immune mechanisms like targeting specific surface antigens,using innate immune cells like the natural killer and T cells,T-cell chimeric antigen receptor technology,dendritic cell vaccine,or immune checkpoint inhibitors.In this respect,better understandings of immune regulatory mechanisms that govern anti-tumor response bring new hope in obtaining long-term remission for cancer therapy. | Mihaela Chivu-Economescu Laura G Necula Lilia Matei Denisa Laura Dragu Ana I Neagu Irina Alexiu Coralia Bleotu Carmen Cristina Diaconu | 2020 | World Journal of Gastroenterology2020，26，14： | 1 |
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