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| 1 | Pancreatic acinar cell carcinoma: a multi-institutional study 显示文摘 | Matos J M Schmidt C M Turrini O | 2009 | J Gastrointest Surg2009，13，8： | 1 |
| 2 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 3 | Dramatic change in Citrus tristeza virus populations in the Dominican Republic显示文摘 | MATOS L A HILF M E CAYETANO X A FELIZ A O HARPER S J FOLIMONOVA S Y | 2013 | Plant Disease2013，97，： | 1 |
| 4 | Multilocus PCR-RFLP analysis of Cryptosporidium isolates from HIV-infected patients from Portugal显示文摘 | Alves M Matos O Antunes F | 2001 | Ann Trop Med Parasitol2001，95，6： | 1 |
| 5 | Pancreas divisum: evaluation with secretin-enhanced magnetic resonance cholangiopancreatography显示文摘 | Matos C Metens T Deviere J Delhaye M Le Moine O Cremer M | 2001 | Gastrointest Endose2001，53，： | 1 |
| 6 | Esterification of Oleic Acid Using 12-Tungstophosphoric Supported in Flint Kaolin of the Amazonia显示文摘 | Júnior O D S L Cavalcanti R M Matos T M D | 2013 | Fuel2013，108，： | 1 |
| 7 | Crack tip deformation -elds and fatigue crack growth rates in Ti-6Al-4V显示文摘 | KORSUNSKY A M SONG X BELNOUE J JUN T HOFMANN F DE MATOS P F P NOWELL D DINI D APRICIO-BLANCO O WALSH M J | 2009 | International Journal of Fatigue2009，31，1112： | 1 |
| 8 | Antiproliferative effect and cell cycle modulaton by melatonin on GH3 cells 显示文摘 | Fornas O Mato M E Webb S M | 2000 | Hormone Res2000，53，： | 1 |
| 9 | Soil microbial biomass under different tillage and levels of applied pig slurry显示文摘 | Balota E L Machineski O Matos M A | 2012 | Revista Brasileira de Engenharia Agrícola e Ambiental2012，16，5： | 1 |
| 10 | Multilocus PCR-RFLP analysis of Cryptosporidium isolates from HIV-infected patients from Portugal显示文摘 | Alves M Matos O Antanes F | 2001 | Annals of Tropical Medicine & Parasitology2001，95，6： | 1 |
| 11 | Antiproliferative effect and cell cycle modulaton by melatonin on GH3 cells 显示文摘 | Fornas O Mato ME Webb M | 2000 | Hormone Res2000，53，： | 1 |
| 12 | Quinovic acid glycosides from Guettarda Angelica 显示文摘 | Matos M E O Sousa M P Machado M I L | 1986 | Phytochemistry1986，25，6： | 1 |
| 13 | A simple approach to reduce dimensionality from comprehensive two-dimensional liquid chromatography coupled with a multichannel detector显示文摘 | MATOS J T V DUARTE R M B O DUARTE A C | 2013 | Analytica Chimica Acta2013，804，： | 1 |
| 14 | Disposable biosensors for determination of bio- genic amines 显示文摘 | Alonso - Lomillo M A Dominguez - Renedo O Matos P | 2010 | Anal Chim Acta2010，665，1： | 1 |
| 15 | Diabetes and oral tumors in Hungary显示文摘 | Ujpal M Matos O Bldok G | | 0，，07： | 1 |
| 16 | Multilocus PCR-RFLP analysis of Cryptosporidium isolates from HIV-infected patients from Portugal显示文摘 | Alves M Matos O Antunes F | 2001 | Annals of Tropical Medicine &Parasitology2001，95，6： | 1 |
| 17 | A novel wavelength dispersive device with a dispersive element based on staircase-like straight and parallel arrayed waveguides显示文摘 | MATOS O M CALVO M L CHEBEN P | 2007 | Opt Commun2007，270，1： | 1 |
| 18 | Diabetes mellitus and tumors of the oral cavity-epidemiologic correlations显示文摘 | Ujpál M Matos O Bíbok G | | 0，，： | 1 |
| 19 | Morphological and yield components and isozyme characterization of Portuguese rye populations显示文摘 | CARNIDE V PINTO-CARNIDE O MATOS M ct al | 1997 | Appl Genet1997，，： | 1 |
| 20 | Photoactive extracts from Thevetia peruviana with antifungal properties against Cladosporium cucumerinum显示文摘 | GATA-GONCALVES L NOGUEIRA J M F MATOS O | 2003 | J Photochem Photobiol B Biol2003，70，1： | 1 |
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