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| 1 | Increased prevalence of intestinal inflammation in patients with liver cirrhosis显示文摘AIM To investigate the pathophysiology of the digestive tract in patients with liver cirrhosis.METHODS In 42 cirrhotic patients and 20control subjects, the following fecal proteinswere measured by enzyme-linkedimmunosorb6nt assay: albumin (Alb ),transferrin (Tf), and al-antitrypsin (a,-AT) as amarker for intestinal protein l0ss, hemoglobin(Hb) for bleeding, PMN-eIastase for intestinalinflammation, and secretory lgA for intestinalimmunity.RESULTS The fecaI concentrations of Hb, Alb,Tf, al-AT, and PMN’eIastase were increased in13 (3l%), 8(19%), l0(24%), 6(14%), and 1l(26%) cases among 42 patients, resPectiveIy.F6cal concentration of secretory IgA wasdecreased in 7 (l7%) of 42 patients. However,these fecal concentrations were not related tothe severity or etiology of liver cirrhosis. Theserum Alb level was significantIy decreased inpatients with intestinal protein Ioss c0mpared tothat in patients without intestinal protein loss.CONCLUSION These findings suggest that: rob6sides the weIl’known pathological conditions,Such as bleeding and protein loss, intestinaIinflammati0n and decreased intestinaI immunityare found in cirrhotic patients, @ intestinalprotein loss contributes to hypoalbuminemia incirrhotic patients, and @ intestinaI inflammationshouId not b6 0verlooked in cirrhotic patients,since it may contribute to or cause intestinalprotein Ioss and oth6r various pathologicalconditions. | Saitoh O Sugi K Lojima K Matsumoto H Nakagawa K Kayazawa M Tanaka S Teranishi T Hirata I Katsu Ki K | 1999 | World Journal of Gastroenterology1999，5，5： | 2 |
| 2 | Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy显示文摘IgG 的 Fc 区域的 Glycosylation 在安全和治疗学的抗体的临床的功效上有深刻影响。当复杂类型的 oligosaccharide 纳入了 Fc 的 Asn297 的 biantennary 为抗体受动器功能是必要的时,海藻糖和外部手臂的糖属于核心 heptasaccharide 产生结构的异质(glycoforms ) 展出唯一的生物活动。因此,有效、量的 glycan 分析技术为治疗学的抗体的发展和质量控制是日益重要的,并且 Fc 的 glycan 侧面作为批评优秀属性被认出。在过去的十年,我们 IgG-Fc 的结构 / 功能上的 glycosylation 的影响的理解通过 X 光检查结晶、原子的磁性的回声研究很快成长了,它为新奇抗体治疗学的设计提供可能性。而且,用基于 endoglycosidase 的 glycosynthases 的 chemoenzymatic glycoengineering 途径可以作为下一代的治疗学的抗体与理想的功能便于同类的 IgG glycoforms 的发展。因此, Fc glycans 是在精确药的时代的治疗学的 IgG 抗体的安全,功能,和功效的改进的肥沃的地面。 | Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd | 2018 | Protein & Cell2018，9，1： | 2 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Hyperchaos:Laboratory experiment and numerical comfirmation显示文摘 | MATSUMOTO T CHUA L O KOBAYASHI K | 1986 | IEEE Transactions on Circuits and Systems1986，33，11： | 1 |
| 5 | Preparation and properties of 5-phenyl-5 H-triazolo-oxadiazole,-thiadizaole, and - selenadizaole 显示文摘 | Matsumoto A Yoshida M Simamura O | 1974 | Bulletin of the Chemical Society of Japan1974，47，6： | 1 |
| 6 | He Double Scroll 显示文摘 | MATSUMOTO T CHUA L O | 1985 | IEEE Trans1985，32，8： | 1 |
| 7 | Maturation of human dendritic cells by cell wall skeleton of Mycobacteri- um bovis bacillus Calmette-Guerin: involvement of toll-like receptors显示文摘 | Tsuji S Matsumoto M Takeuchi O | 2000 | Infect Immun2000，68，12： | 1 |
| 8 | The efficacy of the 'BURP' maneuver during a difficult laryngoscopy显示文摘 | Takahata O Kubota M Mamiya K Akama Y Nozaka T Matsumoto H | 1997 | Anesth Analg1997，84，： | 1 |
| 9 | Maturation of human dendritic cells by cell wall skeleton of mycobacterium bovis Bacillus Calmette-Guerin: involvement of Toll-like receptors显示文摘 | Tsuji S Matsumoto M Takeuchi O | 2000 | Infect Immunity2000，123，3： | 1 |
| 10 | The Double Scroll Family显示文摘 | CHUA L O KOMURO M MATSUMOTO T | 1986 | 1EEE TransCircuit System1986，33，： | 1 |
| 11 | CT differentiation between necrotic and nonnecrotic small bowel in closed loop and strangulating obstruction显示文摘 | Makita O Ikushima I Matsumoto N | 1999 | Abdom Imaging1999，24，2： | 1 |
| 12 | Frontal nonconvulsive status epilepticus manifesting somatic hallucinations显示文摘 | Takaya S Matsumoto R Namiki C Kiyosu H Isono O Hashikawa K | 2005 | J Neurol Sci2005，234，1： | 1 |
| 13 | Rare case of biphasic tumor of the breast with prominent CD34-positive spindle cells显示文摘 | Hayashi M Tamura G Matsumoto O | 2001 | Pathol Int2001，51，9： | 1 |
| 14 | Purine derivative excretion and ruminal microbial yield in Malaysian cattle and swamp buffalo显示文摘 | Liang J B Pimpa O Matsumoto M | 1994 | Anim Feed Sci Technol1994，，47： | 1 |
| 15 | Atropine premedication attenuates heart rate variability during high thoracic epidural anesthesia显示文摘 | Kawamoto M Matsumoto C Yuge O | 1996 | Acta Anaesthesiol Scand1996，40，9： | 1 |
| 16 | Molecular phylogeny of orthopteroid insects based on mitochondrial cytochrome oxidase Ⅱ gene显示文摘 | Maekawa K Kitade O Matsumoto T | 1999 | Zool Sci1999，16，： | 1 |
| 17 | Preparation and properties of 5-phenyl-5H -triazolo -oxadiazole,-thiadizaole,and -selenadizaole显示文摘 | Matsumoto A Yoshida M Simamura O | 1974 | Bulletin of the Chemical Society of Japan1974，47，6： | 1 |
| 18 | CT differentiation between necrotic and nonnecrotic small bowel in closed loop and strangulating obstruction显示文摘 | Makita O Ikushima I Matsumoto N | 1999 | Abdom Imaging1999，24，2： | 1 |
| 19 | An Integrated Micro Fluxgate Magnetic Sensor显示文摘 | Choi S O Kawahito S Matsumoto Y | 1996 | Sensors and Actuators a-Physical1996，55，23： | 1 |
| 20 | Protein S-nitrosylation:purview and parameters显示文摘 | Hess D T Matsumoto A Kim S O | 2005 | Nat Rev Mol Cell Biol2005，6，2： | 1 |
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