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	题名	作者	年代	出处	被引量
1	脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。	Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊	2018	神经损伤与功能重建2018，13，4：	4
2	Effect of spinal cord preconditioning on paraplegia during cross-clamping of the thoracic aorta显示文摘	Matsuyama K Chiba Y Ihaya A Kimura T Tanigawa N Muraoka R	1997	Ann Thorac Surg1997，63，5：	2
3	High-quality Polycrystalline Silicon Thin Film Prepared by a Solid Phase Crystallization Method显示文摘	Terada N Matsuyama T Baba T	1996	J Non-crystalline Solids1996，，：	1
4	FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases显示文摘	Furumai R Matsuyama A Kobashi N	2002	Cancer Res2002，62，17：	1
5	FK228 (Depsipeptide) as a natural prodrug that inhibits class Ⅰ histone deacetylases显示文摘	Furumai R Matsuyama A Kobashi N	2002	Cancer Res2002，62，17：	1
6	Detection of anti-human platelet antibodies against integrin α2β1 using cell lines显示文摘	Hayashi T Amakishi E Matsuyama N	2014	Blood Transfus2014，12，1：	1
7	FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases 显示文摘	Furumai R Matsuyama A Kobashi N	2002	Cancer Research2002，62，17：	1
8	Release of nutrients from resin coated fertilizers as affected by temperature and time显示文摘	Tamimi Y N Matsuyama D T Robbins C L	1983	Journal of College of Tropical Agriculture and Human Resources University of Hoawaii1983，37，1：	1
9	Real-time cooperative multi-target tracking by communicating active vision agents显示文摘	Ukita N Matsuyama T	2005	Computer Vision and Image Understanding2005，97，2：	1
10	Novel ring opening reaction of 2-aryl-1,2-benzisoselenazol-3(2H)-one with thiols显示文摘	Kamigata N Takata M Matsuyama H	1986	Heterocycles1986，24，：	1
11	Relations of lysophosphatidylcholine in low-density lipo- protein with serum lipoprotein-associated phospholipase A2, paraoxonase and homocysteine thiolactonase activities in pa- tients with type 2 diabetes mellitns 显示文摘	Sonoki K Iwase M Sasaki N Ohdo S Hignchi S Matsuyama N	2009	Diabetes Res Clin Pract2009，86，2：	1
12	Effects of ozone exposure on the gene expression of ethylene biosynthetic enzymes in tomato leaves显示文摘	Nakajima N Matsuyama T Tasanori T Saji H Aono M Kubo A Kondo N	2001	Plant Physiol Biochem2001，39，：	1
13	Release of nutrients from resin coated fertilizers as affected by temperature and time显示文摘	Tamimi Y N Matsuyama D T Robbins C L	1983	Res Ext Seri-Coll Trop Agrie Human Res Univ Hawaii1983，37，：	1
14	Pulmonary lesionsassociated with Sjogren^s syndrome: radiographic and CT findings显示文摘	Matsuyama N Ashizawa K Okimoto T	2003	BrJ Radiol2003，76，912：	1
15	Estab- lishment of a cell line panel as an alternative source of platelet antigens for a screening assay of anti-human platelet antibod- ies显示文摘	HAYASHI T AMAKISHI E MATSUYAMA N	2011	Transfus Med2011，21，：	1
16	Decomposition of volatile organic compounds by a novel electrode syste integrating ceramic filter and SPCP method 显示文摘	Harada N Matsuyama T Yamamoto H	2007	Journal of Electrostatics2007，65，：	1
17	FK228 (depsipeptide) as a natural prodrug that inhibits class I histone dcacetylases 显示文摘	FURUMAI R MATSUYAMA A KOBASHI N	2002	Cancer Res2002，62，17：	1
18	Morphologicvariations of dense deposit disease: light and electron microscopic, immunohistochemical and clinical findings in 10 patients显示文摘	Joh K Aizawa S Matsuyama N	1993	Acta Pathol Jpn1993，43，10：	1
19	Nucleotide sequence and characterization of erythromycin resistance determinant that encodes macrolide 2'-phosphotransferase I in Escherichia coli显示文摘	Noguchi N Emura A Matsuyama H	1995	Antimicrob Agents Chemother1995，39，10：	1
20	Clinical outcomes of biological effe-ctive dose-based fractionated stereotactic radiation therapy for metastaticbrain tumors from non-small cell lung cancer显示文摘	Matsuyama T Kogo K Oya N	2013	Int J Radiat Oncol Biol Phys2013，85，：	1

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