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| 1 | Adiponectin deficiency exacerbates lipopolysaccharide/ D-galactosamine-induced liver injury in mice显示文摘瞄准:在 Kupffer 房间的功能上检验 adiponectin 的效果,脂肪的多糖(LPS ) 的关键调节的人导致了肝损伤。方法:D-galactosamine (GalN ) 和 LPS intraperitoneally 被注入 adiponectin-/- 老鼠和野类型老鼠。Kupffer 房间,从 Sprague-Dawley 孤立老鼠,是 preincubated 与或没有 adiponectin,然后与 LPS 对待。结果:在猛烈老鼠, GalN/LPS 注射显著地降低了幸存率,显著地提起了丙氨酸转氨酶和肿瘤坏死 factor-alpha (TNF-alpha ) 的血浆层次并且显著地减少了与野类型老鼠相比的 IL-10 层次。在肝的 TNF-alpha 基因表示是哪个更高并且 IL-10 的那些比在野类型老鼠在猛烈老鼠是更低的。在有教养的 adiponectin-pre-treated Kupffer 房间, LPS 显著地降低了 TNF-alpha 层次并且在培养基和他们的各自的基因表示层次提起了 IL-10 层次,与没有 adiponectin-pre-treatment 的 Kupffer 房间相比。结论:Adiponectin supresses TNF-alpha 生产并且响应 LPS 刺激由 Kupffer 房间导致 IL-10 生产,并且 adiponectin 的缺乏提高导致 LPS 的肝损伤。 | Hitoshi Matsumoto Shinji Tamura Yoshihiro Kamada Shinichi Kiso Juichi Fukushima Akira Wada Norikazu Maeda Shinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro Shimomura Norio Hayashi | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 2 | Clinical impacts of mesothelin expression in gastrointestinal carcinomas显示文摘Mesothelin,C-ERC/mesothelin is a 40-kD a cell surface glycoprotein that is normally present on normal mesothelial cells lining the pleura,peritoneum,and pericardium.Moreover,mesothelin has been shown to be overexpressed in several human cancers,including virtually all mesothelioma and pancreatic cancer approximately 70% of ovarian cancer and extra bile duc cancer,and 50% of lung adenocarcinomas and gastric cancer.The full-length human mesothelin gene encodes the primary product,a 71-k Da precursor protein.The71-kD a mesothelin precursor is cleaved into two products40-k Da C-terminal fragment that remains membranebound via glycosylphosphatidylinositol anchor,and a31-kD a N-terminal fragment,megakaryocyte potentiating factor,which is secreted into the blood.The biologica functions of mesothelin remain largely unknown However,results of recent studies have suggested tha the mesothelin may play a role of cell proliferation and migration.In pancreatic cancer,mesothelin expression was immunohistochemically observed in all cases,bu absent in normal pancreas and in chronic pancreatitis Furthermore,the expression of mesothelin was correlated with an poorer patient outcome in severa human cancers.The limited mesothelin expression in normal tissues and high expression in many cancers makes it an attractive candidate for cancer therapy.The present review discusses the expression and function o mesothelin in cancer cells and the utility of mesothelin as a target of cancer therapy. | Takahiro Einama Futoshi Kawamata Hirofumi Kamachi Hiroshi Nishihara Shigenori Homma Fumihiko Matsuzawa Tatsuzo Mizukami Yuji Konishi Munenori Tahara Toshiya Kamiyama Okio Hino Akinobu Taketomi Satoru Todo | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，2： | 4 |
| 3 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 4 | Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis显示文摘 | Mitsuhiro Yokoyama Hideki Origasa Masunori Matsuzaki Yuji Matsuzawa Yasushi Saito Yuichi Ishikawa Shinichi Oikawa Jun Sasaki Hitoshi Hishida Hiroshige Itakura Toru Kita Akira Kitabatake Noriaki Nakaya Toshiie Sakata Kazuyuki Shimada Kunio Shirato | 2007 | The Lancet2007，，9567： | 2 |
| 5 | Fouling and structural changes of Shirasu porous glass (SPG) membrane used in aerobic wastewater treatment process for microbubble aeration显示文摘 | Chun Liu Hiroshi Tanaka Lei Zhang Jing Zhang Xia Huang Jin Ma Yoshiaki Matsuzawa | 2012 | Journal of Membrane Science2012，，： | 2 |
| 6 | Critical Function for SIP, a Ubiquitin E3 Ligase Component of the β-Catenin Degradation Pathway, for Thymocyte Development and G1 Checkpoint显示文摘 | Toru Fukushima Juan M. Zapata Netai C. Singha Michael Thomas Christina L. Kress Maryla Krajewska Stan Krajewski Ze’ev Ronai John C. Reed Shu-ichi Matsuzawa | 2006 | Immunity2006，，1： | 2 |
| 7 | Siah-1, SIP, and Ebi Collaborate in a Novel Pathway for β-Catenin Degradation Linked to p53 Responses显示文摘 | Shu-ichi Matsuzawa John C. Reed | 2001 | Molecular Cell2001，，5： | 2 |
| 8 | Siah-1, SIP and Ebi collaborate in a novelpathway for β-Catenin degradation linked to p53 response 显示文摘 | Matsuzawa S Reed JC | 2001 | Molcell2001，7，5： | 2 |
| 9 | Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Yoshihisa Okamoto Kazuhisa Maeda Hiroshi Kuriyama Kikuko Hotta Makoto Nishida Masahiko Takahashi Masahiro Muraguchi Yasukazu Ohmoto Tadashi Nakamura Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2000 | Circulation: Journal of the American Heart Association2000，，11： | 2 |
| 10 | Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages显示文摘 | Noriyuki Ouchi Shinji Kihara Yukio Arita Makoto Nishida Akifumi Matsuyama Yoshihisa Okamoto Masato Ishigami Hiroshi Kuriyama Ken Kishida Hitoshi Nishizawa Kikuko Hotta Masahiro Muraguchi Yasukazu Ohmoto Shizuya Yamashita Tohru Funahashi Yuji Matsuzawa | 2001 | Circulation: Journal of the American Heart Association2001，，8： | 2 |
| 11 | A new phosphorescent phosphor with high brightness SrAl2O4:Eu^2 + ,Dy^3+ 显示文摘 | Matsuzawa T Aoki Y Takcuchi N | 1996 | Electrochemical Society1996，143，： | 1 |
| 12 | Biology of mouse mammary tumor virus(MMTV)显示文摘 | Matsuzawa A Nakano H Yoshimoto T | 1995 | Caner Lett1995，90，1： | 1 |
| 13 | Airway pressure release ventilation reduces the increase in bronchoalveolar lavage fluid high - mobility group box - 1 levels and lung water experi- mental acute respiratory distress syndrome induced by lung lavage 显示文摘 | Matsuzawa Y Nakazawa K Yamamura A | 2010 | Eur J Anaesthesiol2010，27，8： | 1 |
| 14 | The metabolic syndrome:a global public health problem and a new definition 显示文摘 | Zimmet P Magliano D Matsuzawa Y | 2005 | Journal of Atherosclerosis and Thrombosis2005，12，6： | 1 |
| 15 | Effect of hydrophobic chain length of amphiphilic silicone oil (copolymer) on the nonionic surfactant - layer curvature 显示文摘 | KANEKO M MATSUZAWA K UDDIN M H | 2004 | Journal of Physical Chemistry B2004，108，12： | 1 |
| 16 | Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia显示文摘 | Weyer C Funahashi T Tanaka S Hotta K Matsuzawa Y Pratley R E | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 17 | Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease显示文摘 | Zoccali C Mallamaci F Tripepi G Benedetto FA Cutrupi S Parlongo S Malatino LS Bonanno G Seminara G Rapisarda F Fatuzzo P Buemi M Nicocia G Tanaka S Ouchi N Kihara S Funahashi T Matsuzawa Y | 2002 | J Am Soc Nephrol2002，13，1： | 1 |
| 18 | Physiological roles of ASKI-mediated signal transduction in oxidative stress-and endoplasmic reticulum stress-induced apoptosis : advanced findings from ASKI knockout mice显示文摘 | Matsuzawa A Nishitoh H Tobiume K Takeda K Ichijo H | 2002 | Antioxid Redox Signal2002，4，3： | 1 |
| 19 | Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside - Rb2,20 (R) - and 20 (S) - ginsenoside - Rg3, of red ginseng 显示文摘 | Mochizuki M Yoo YC Matsuzawa K | 1995 | Biol Pharm Bu111995，18，9： | 1 |
| 20 | Adiponectin and metabolic syndrome显示文摘 | Matsuzawa Y Funahashi T Kihara S | 2004 | Arterioscler Thromb Vasc Biol2004，24，： | 1 |
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