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| 1 | Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome显示文摘AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. | Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen Pentti Sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 2 | Reliability of CBCT and other radiographic methods in preoperative evalua- tion of lower third molars显示文摘 | Suomalainen A Ventfi I Mattila M | 2010 | Oral and maxillofaeial radiolo- gy2010，109，2： | 1 |
| 3 | Biochar addition to agricultural soil increased CH4 uptake and water holding capacity-term pilot field study 显示文摘 | Karrhu K Mattila T Bergstrom I | 2011 | Agriculture Ecosystems & Environment2011，140，12： | 1 |
| 4 | Reliability of CBCT and other radiographic methods in preoperative evaluation of lower third molars显示文摘 | Suornalainen A Venta I Mattila M | 2010 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2010，109，2： | 1 |
| 5 | Reliability of CBCT and other radiographic methods in preoperative evaluation of lower third molars 显示文摘 | Suomalainen A Vent? I Mattila M | 2010 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2010，109，2： | 1 |
| 6 | Biochar addition to agricultural soil increased CI-L uptake and water holding capacity:Results from a short-term pilot field study显示文摘 | Karhu K Mattila T BergstrOm I | 2011 | Agriculture Ecosystems and Environmer2011，140，1： | 1 |
| 7 | Phylogenetic relationship of Fusarium langsethiae to Fusarium poaeand Fusarium sporotrichioidesas inferred by IGS,ITS,β-tubulin sequences and UP-PCR hybridization analysis显示文摘 | Mattila T Mach R L Alekhina I A | 2004 | International Journal of Food Microbiology2004，95，3： | 1 |
| 8 | Biochar addition to agricultural soil increased CH4 uptake and water holding capacity-Results from a short-term pilot field study显示文摘 | Karhu K Mattila T Bergstrom I | 2011 | Agriculture Ecosystems and Environment2011，140，12： | 1 |
| 9 | Biochar addition to agricultural soil increased CH4 uptake and water holding capacity- Results from a short-term pilot field study显示文摘 | Karhu K Mattila T Bergstrom I | 2011 | Agriculture Ecosystems and Environment2011，140，： | 1 |
| 10 | Understanding restaurant switching behavior from a cuhural perspective 显示文摘 | Lin I Y H Mattila A S | 2006 | Journal of Hospitality and Tourism Research2006，30，1： | 1 |
| 11 | Biochar addition to agricultural soil increased CH4 uptake and water holding capacity-results from a short-term pilot field study显示文摘 | Karhu K Mattila T Bergstr om I | | Agriculture Ecosystems and Environment0，，： | 1 |
| 12 | Bioactive glass S53P4 and autograft bone in treatment of depressed tibial plateau fractures-a prospective randomized 11-year fol ow-up显示文摘 | Pernaa K Koski I Mattila K | | 0，，02： | 1 |
| 13 | Bioehar addition to agrieuhural soil increased CH4 uptake and water holding capacity-term pilot field study 显示文摘 | Karrhu K Mattila T Bergstrom I | 2011 | Agriculture Ecosystems & Environment2011，140，12： | 1 |
| 14 | Vitamin D contents in edible mushrooms显示文摘 | Mattila P H Piironen V I Uusi-rauva E J | | 0，，11： | 1 |
| 15 | Biochar addition to agricultural soil increased CtL uptake and water holding capacity- results from a short-term pilot field study显示文摘 | Karhu K Mattila T Bergstrom I | 2011 | Agriculture Ecosystems and Environment2011，140，1： | 1 |
| 16 | Bioactive glass S53P4 and autograft bone in treatment of depressed tibial plateau fractures-a prospective randomized 11-year follow-up显示文摘 | Pernaa K Koski I Mattila K | | 0，，02： | 1 |
| 17 | Direct reconstruction of the pulmonary artery during the arterial switch operation: an interesting surgical option with excellent hemodynamic results 显示文摘 | Carrel T Mattila I Pfammatter JP | 1998 | Ann Thorac Stag1998，65，4： | 1 |
| 18 | Phylogenetic relationship of Fusarium langsethiae to Fusarium poae and Fusarium sporotrichioides as inferred by IGS, ITS,β-tubulin sequences and UP-PCR hybridization analysis 显示文摘 | Yli Mattila T Mach R L Alekhina I A | 2004 | International Journal of Food Microbiology2004，95，3： | 1 |
| 19 | Phylogenetic relationship of Fusarium langsethiae to Fusarium poae and Fusarium sporotrichioides as inferred by IGS, ITS, β-tubulin sequences and UPPCR hybridization analysis 显示文摘 | Yli Mattila T Mach R L Alekhina I A | 2004 | International Journal of Food Microbiology2004，95，3： | 1 |
| 20 | Vitamin D supplementation for the prevention of acute respiratory tract infection:a randomized,double-blinded trial among young Finnish men显示文摘 | Laaksi I Ruohola J P Mattila V | 2010 | J Infect Dis2010，202，5： | 1 |
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