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| 1 | Radiofrequency ablation of liver tumors: Actual limitations and potential solutions in the future显示文摘Over the past decade,radiofrequency ablation(RFA) has evolved into an important therapeutical tool for the treatment of non resectable primary and secondary liver tumors.The clinical benefit of RFA is represented in several clinical studies.They underline the safety and feasibility of this new and modern concept in treating liver tumors.RFA has proven its clinical impact not only in hepatocellular carcinoma(HCC) but also in metastatic disease such as colorectal cancer(CRC).Due to the increasing number of HCC and CRC,RFA might play an even more important role in the future.Therefore,the refinement of RFA technology is as important as the evaluation of data of prospective randomized trials that will help define guidelines for good clinical practice in RFA application in the future.The combination of hepatic resection and RFA extends the feasibility of open surgical procedures in patients with extensive tumors.Adverse effects of RFA such as biliary tract damage,liver failure and local recurrence remain an important task today but overall the long term results of RFA application in treating liver tumors are promising.Incomplete ablation of liver tumors due to insufficient technology of ablation needles,tissue cooling by the neighbouring blood vessels,large tumor masses and ablation of tumors in close vicinity to heat sensitive organs remain difficult tasks for RFA.Future solutions to overcome these limitations of RFA will include refinement of ultrasonographic guidance(accuracy of probe placement),improvements in needle technology(e.g.needles preventing charring)and intraductal cooling techniques. | Beat M Künzli Paolo Abitabile Christoph A Maurer | 2011 | World Journal of Hepatology2011，3，1： | 15 |
| 2 | Liver resections can be performed safely without Pringle maneuver: A prospective study显示文摘AIM To evaluate liver resections without Pringle maneuver, i.e., clamping of the portal triad. METHODS Between 9/2002 and 7/2013, 175 consecutive liver resections(n = 101 major anatomical and n = 74 large atypical > 5 cm) without Pringle maneuver were performed in 127 patients(143 surgeries). Accompanying, 37 wedge resections(specimens < 5 cm) and 43 radiofrequency ablations were performed. Preoperative volumetric calculation of the liver remnant preceeded all anatomical resections. The liver parenchyma was dissected by waterjet. The median central venous pressure was 4 mmH g(range: 5-14). Data was collected prospectively. RESULTS The median age of patients was 60 years(range: 16-85). Preoperative chemotherapy was used in 70 cases(49.0%). Liver cirrhosis was present in 6.3%, and liver steatosis of ≥ 10% in 28.0%. Blood loss was median 400 mL(range 50-5000 mL). Perioperative blood transfusions were given in 22/143 procedures(15%). The median weight of anatomically resected liver specimens was 525 g(range: 51-1850 g). One patient died postoperatively. Biliary leakages(n = 5) were treated conservatively. Temporary liver failure occurred in two patients.CONCLUSION Major liver resections without Pringle maneuver are feasible and safe. The avoidance of liver inflow clamping might reduce liver damage and failure, and shorten the hospital stay. | Christoph A Maurer Mikolaj Walensi Samuel A Kaser Beat M Künzli Rene Lotscher Anne Zuse | 2016 | World Journal of Hepatology2016，8，24： | 6 |
| 3 | 急性冠状动脉综合征发生1个月后的生长分化因子15水平与主要出血风险增加相关显示文摘用双重抗血小板治疗的急性冠状动脉综合征(acutecoronarysyndromes,ACS)患者在初次就诊测量的生长分化因子15(growthdifferentiationfactor-15,GDF-15)与大出血相关。 | Lindholm D Hagstrm E James SK Becker RC Cannon CP Himmelmann A Katus HA Maurer G López-Sendón JL Steg PG Storey RF Siegbahn A Wallentin L 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 5 |
| 4 | Glycosaminoglycans enhance human leukemic cell growth in vitro显示文摘 | Maurer A M Han Z C Dhermy D | 1994 | Leuk Res1994，18，11： | 2 |
| 5 | Episodes of hypocarbia and early-onset sepsis are risk factors for cystic periventricular leukomalacia in the preterm infant显示文摘 | B. Resch K. Neubauer N. Hofer E. Resch U. Maurer J. Haas W. Müller | 2011 | Early Human Development2011，，1： | 2 |
| 6 | Y chromosome microdeletion screening in infertile2men 显示文摘 | Maurer B Simoni M | 2000 | J Endocrinol Invest2000，23，10： | 1 |
| 7 | GRI pursues goal of commercial through-casing resistivity measurement 显示文摘 | Maurer I-I M Fanini O Strack K M | 1996 | Oil and Gas1996，32，2： | 1 |
| 8 | Regional chemotherapy of gastro-intestinal cancer显示文摘 | Maurer CA Bomer M Buchler MW | 1997 | Dig Surg1997，14，： | 1 |
| 9 | Effects of gene dosage,promoters,and substrates on unfolded protein stress of recombinant Pichia pastoris显示文摘 | Hohenblum H Gasser B Maurer M | 2004 | Biotechnol Bioeng2004，85，4： | 1 |
| 10 | Nutrients in urine/ energetical aspects of removal and recovery 显示文摘 | Maurer M Schwegler P Larsen T A | 2003 | Water Sci Technol2003，48，1： | 1 |
| 11 | Expressionof LM02 is associated with t(14;18)/IGH-BCL2 fusion but notBCL6 translocations in diffuse large B-cell lymphoma 显示文摘 | DURNICK D K LAW M E MAURER M J | 2010 | Am J Clin Pathol2010，134，2： | 1 |
| 12 | Characterization of functional vanilloid receptors expressed by mast cells显示文摘 | Biro T Maurer M Modarres S | 1998 | Blood1998，91，4： | 1 |
| 13 | Regional chemothenapy lr gastrointestinal cancer 显示文摘 | Maurer CA Bomer M Buchler MW | 1977 | Dig Surg1977，14，1： | 1 |
| 14 | Mastcell functions in the innate skin immune system显示文摘 | METZ M SIEBENHAAR F MAURER M | 2008 | Immunobiology2008，213，3： | 1 |
| 15 | Inflammatory skin responses induced by icati- bant injection are mast cell mediated and attenuated by HI-antihista- mines显示文摘 | Maurer M Church MK | 2012 | Exp Dermatol2012，21，2： | 1 |
| 16 | Hospitalization for heart failure in the presence of a normal left ventricular ejection fraction: results of the New York heart failure registry显示文摘 | Klapholz M Maurer M I owe AM | 2004 | J Am (7oll Cardiol2004，43，8： | 1 |
| 17 | Scope and limitations of methods of mandibular reconstruc- tion: a long-term follow-up显示文摘 | MAURER P ECKERT A W KRIWALSKY M S | 2010 | The British Journal of Oral Maxillofacial Surgery2010，48，2： | 1 |
| 18 | Impaired mast cell-dependent natural immunity in complement C3-deficient mice 显示文摘 | Prodeus AP Zhou X Maurer M | 1997 | Nature1997，390，6656： | 1 |
| 19 | Investigations of urothelial cells seeded on commercially available small intestine submueosa 显示文摘 | Feil G Christ-Adler M Maurer S | 2006 | Eur Urol2006，50，6： | 1 |
| 20 | Photoswitchable spiro- benzopyran-based photochemically controlled photonic crys- tals显示文摘 | Maurer M K Lednev I K Asher S A | 2005 | Adv Funct Mater2005，15，9： | 1 |
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