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| 1 | Association of nonalcoholic fatty liver disease and liver cancer显示文摘AIM:To investigate the association between nonalcoholic fatty liver disease(NAFLD) and liver cancer,and NAFLD prevalence in different liver tumors.METHODS:This is a retrospective study of the clinical,laboratory and histological data of 120 patients diagnosed with primary or secondary hepatic neoplasms and treated at a tertiary center where they underwent hepatic resection and/or liver transplantation,with subsequent evaluation of the explant or liver biopsy.The following criteria were used to exclude patients from the study:a history of alcohol abuse,hepatitis B or C infection,no tumor detected in the liver tissue examined by histological analysis,and the presence of chronic autoimmune hepatitis,hemochromatosis,Wilson's disease,or hepatoblastoma.The occurrence of NAFLD and the association with its known risk factors were studied.The risk factors considered were diabetes mellitus,impaired glucose tolerance,impaired fasting glucose,body mass index,dyslipidemia,and arterial hypertension.Presence of reticulin fibers in the hepatic neoplasms was assessed by histological analysis using slide-mounted specimens stained with either hematoxylin and eosin or Masson's trichrome and silver impregnation.Analysis of tumor-free liver parenchyma was carried out to determine the association between NAFLD and its histological grade.RESULTS:No difference was found in the association of NAFLD with the general population(34.2% and 30.0% respectively,95%CI:25.8-43.4).Evaluation by cancer type showed that NAFLD was more prevalent in patients with liver metastasis of colorectal cancer than in patients with hepatocellular carcinoma and intrahepatic cholangiocarcinoma(OR = 3.99,95%CI:1.78-8.94,P < 0.001 vs OR = 0.60,95%CI:0.18-2.01,P = 0.406 and OR = 0.70,95%CI:0.18-2.80,P = 0.613,respectively).There was a higher prevalence of liver fibrosis in patients with hepatocellular carcinoma(OR = 3.50,95%CI:1.06-11.57,P = 0.032).Evaluation of the relationship between the presence of NAFLD,nonalcoholic steatohepatitis,and liver fibrosis,and their risk factors,showed no significant statistical association for any of the tumors studied.CONCLUSION:NAFLD is more common in patients with liver metastases caused by colorectal cancer. | Perla Oliveira Schulz Fabio Goncalves Ferreira Maria de Fátima Araújo Nascimento Andrea Vieira Mauricio Alves Ribeiro André Ibrahim David Luiz Arnaldo Szutan | 2015 | World Journal of Gastroenterology2015，21，3： | 2 |
| 2 | Treatment of highgrade glioma patients with the humanized anti - epidermal growth factor receptor (EGFR) antibody h - R3 : Report from a phase I/Ⅱ trial显示文摘 | Tania C R Javier F Mauricio C | 2006 | Cancer Biol Ther2006，5，4： | 1 |
| 3 | A semi-auto mated in vitro gas production technique :显示文摘 | Mauricio R M Mould F L Dhanoa M S | 1999 | Animal Feed Science and Technology1999，79，： | 1 |
| 4 | Overlapping bin- ding site for trypsin and papain on a Kunitz-type proteinase inhibitor from Prosopsis juliflora显示文摘 | Octavio L F Maria F G Mauricio P S | 2002 | Proteins:structure function and genetics2002，49，3： | 1 |
| 5 | Comparison of bo- vine rumen liquor and bovine faeces as inoculums for an in vitro gas production technique for evaluating forages 显示文摘 | MAURICIO R OWEN E MOULD F L | 2001 | Anim Feed Sci Tech2001，89，： | 1 |
| 6 | PTEN promoter methylation in sporadic thyroid carcinomas 显示文摘 | Alvarez-Nunez F Bussaglia E Mauricio D | 2006 | Thyroid2006，16，1： | 1 |
| 7 | A diffusion model for describing water transport in round squid mantle during with a moisture-dependent effective diffusivity显示文摘 | Mauricio B Teixeim F Satoshi T | 1998 | Food Eng1998，36，2： | 1 |
| 8 | Possible Involvement of different connexin 43 domains in plasma membrane permeabilization induced by ischemia-reperfusion 显示文摘 | Mauricio A Kurt A Kenji F | 2007 | J Membrane Biol2007，218，13： | 1 |
| 9 | A semi-automated in vitro gas production technique for ruminant feedstuff evaluation显示文摘 | Mauricio R M Mould F L Dhanoa M S | 1999 | Animal Feed Science and Technology1999，79，： | 1 |
| 10 | Models of Liquid Storage Tanks显示文摘 | KAMAL A R IsmaiI JANAINA F B Leal MAURICIO A Zanardi | 1997 | Energy1997，22，8： | 1 |
| 11 | A semi-automated in vitro gas production technique for ruminant feedstuff evaluation显示文摘 | Mauricio R M Mould F L Dhanoa M S | 1999 | Animal Feed Science and Technology1999，79，： | 1 |
| 12 | Creep and shrinkage of high-performance lightweight concrete显示文摘 | Mauricio L Lawrence F K Kimberly E K | 2004 | ACI Materials Journal2004，101，5： | 1 |
| 13 | A semi-automated in vitro gas production technique for ruminant feedstuff evaluation显示文摘 | Mauricio R M Mould F L Dhanoa M S | | 0，，4： | 1 |
| 14 | Small volume hypertonic resuscitation of circulatory shock显示文摘 | Mauricio Rocha-e-Silva Luiz F Poli de Figueiredo | 2005 | Clinics2005，60，2： | 1 |
| 15 | A semi- automated in vitro gas production technique for ruminant feedstuff evaluation显示文摘 | Mauricio R M Mould F L Dhanoa M S | 1999 | Anim Feed Sci Technol1999，79，4： | 1 |
| 16 | Monotone positive solutions for a fourth order equation with nonlinear boundary conditions显示文摘 | EDSON A TO F M MAURICIO L P | 2009 | Nonlinear Analysis2009，71，9： | 1 |
| 17 | Effects of filling techniques on the regional bond strength to lateral walls in Class I cavities显示文摘 | Félix SA González-López S Mauricio PD | | 0，，06： | 1 |
| 18 | Analysis of the mechanical behavior and characterization of puhruded glass fiber-resin matrix composites 显示文摘 | PACIORNIK S MARTINHO F M DE Mauricio MHP | 2003 | Composites Science and Technology2003，63，2： | 1 |
| 19 | Adult attachment o- rientations andcollege student distress : The mediating role of prob- lem coping styles显示文摘 | Lopez F G Mauricio A M Barbara G | 2001 | J Couns Dev2001，79，4： | 1 |
| 20 | PTEN promoter methylation in sporadic thyroid carcinomas显示文摘 | Alvarez-Nunez F Bussaglia E Mauricio D | 2006 | Thyroid2006，16，1： | 1 |
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