|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Trans-presentation of interleukin-15 by interleukin-15 receptor alpha is dispensable for the pathogenesis of autoimmune type 1 diabetes显示文摘Interleukin-15(IL-15)is a pro-inflammatory cytokine that is required for the survival and activation of memory CD8^(+)T cells,natural killer(NK)cells,innate lymphoid cells,macrophages and dendritic cells.IL-15 is implicated in the pathogenesis of various autoimmune diseases such as rheumatoid arthritis,inflammatory bowel disease,psoriasis and autoimmune type 1 diabetes(T1D).IL-15 receptor(IL-15R)consists of a specificαchain,theβchain that is shared with IL-2R and the commonγchain.IL-15 is unique in the manner in which it binds and signals through its receptor subunits.IL-15 that is complexed with IL-15Rαbinds to theβγreceptor complex present on the responding cell to mediate its biological effects through a process referred to as trans-presentation.The trans-presented IL-15 is essential to mediate the biological effects on T lymphocytes and NK cells.Here we show that IL-15,but not IL-15Rα,is required for the development of spontaneous and virus-induced T1D,viral clearance and for antigen cross-presentation to CD8^(+)T lymphocytes.Our findings provide insight into the complexities of IL-15 signalling in the initiation and maintenance of CD8^(+)T cell-mediated immune responses. | Diwakar Bobbala Marian Mayhue Alfredo Menendez Subburaj Ilangumaran Sheela Ramanathan | 2017 | Cellular & Molecular Immunology2017，14，7： | 2 |
| 2 | Molecular characterization and expression analysis of the porcine paraoxonase 3 ( PON3 ) gene 显示文摘 | Labrecque B Beaudry D Mayhue M | 2009 | Gene2009，443，12： | 1 |
| 3 | Molecular characterization and expression analysis of the porcine paraoxonase 3 (pon3) gene显示文摘 | LABRECQUE B BEAUDRY D MAYHUE M | | 0，，1： | 1 |
| 4 | Development of a control rod depletion methodology for the Westinghouse NEXUS sys- tem显示文摘 | FRANCESCHINI F ZHANG B MAYHUE L etal | 2013 | Progress in Nuclear Energy2013，68，7： | 1 |
| 5 | Visfatin expression is not associated with adipose tissue abundance in the porcine model显示文摘 | Palin M F Labrecque B Beaudry D Mayhue M Bordignon V Murphy B D | | 0，，： | 1 |
| 6 | I L- 15 trans-presentation regulates homeostasis of CD4^+ T lymphocytes显示文摘Interleukin-15 (IL-15 ) 为记忆 CD8 + 和 CD4 + T 的幸存是必要的房间子集,和天赋漂亮、自然的漂亮 T 房间。这里,我们描述一迄今在调整天真的 CD4 + T 房间的 homoeostasis 的 IL-15 的 unreported 角色。从非肥胖的糖尿病患者(点头) 的 splenocytes 的采纳转移在在 lymphopenic NOD.scid.Il15 −/− 老鼠的 T 房间的增加的 homeostatic 扩大的老鼠结果什么时候与 NOD.scid 接受者相比。CD4 + T 房间的增加的累积也在 NOD.Il15 −/− 老鼠被观察,显示那条 IL-15-dependent 规定也当淋巴球减少症不在时发生。缺乏 IL-15Rα 的 NOD.scid 老鼠;锁住,然而并非缺乏普通 gamma 的那些也锁住表演 CD4 + T 房间的增加的累积。这些调查结果显示 IL-15-mediated 规定在 CD4 + T 房间上直接发生并且要求 IL-15 的 trans 演讲。当 IL-15 不在时膨胀发信号的 CD4 + T 房间不获得古典规章的 T 房间的特征。更确切地说,当 IL-15 表演不在时膨胀的 CD4 + T 房间损害了导致抗原的激活和 IFN-γ生产。把调查结果基于这些,我们建议天真的 CD4 +T 房间分隔空间的 IL-15-dependent 规定可以代表控制的另外的层潜在地阻挠逃离中央忍耐的 autoreactive 房间,当允许记忆 T 房间的扩大时。 | Xi-Lin Chen Diwakar Bobbala Yuneivy Cepero Donates Marian Mayhue Subburaj Ilangumaran Sheela Ramanathan | 2014 | Cellular & Molecular Immunology2014，11，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员