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| 1 | Role of frailty and sarcopenia in predicting outcomes among patients undergoing gastrointestinal surgery显示文摘According to the United States census bureau 20% of Americans will be older than 65 years in 2030 and half of them will need an operation- equating to about 36 million older surgical patients. Older adults are prone to complications during gastrointestinal cancer treatment and therefore may need to undergo special pretreatment assessments that incorporate frailty and sarcopenia assessments. A focused, structured literature review on Pub Med and Google Scholar was performed to identify primary research articles, review articles, as well as practice guidelines on frailty and sarcopenia among patients undergoing gastrointestinal surgery. The initial search identified 450 articles; after eliminating duplicates, reports that did not include surgical patients, case series, as well as case reports, 42 publications on the impact of frailty and/or sarcopenia on outcome of patients undergoing gastrointestinal surgery were included. Frailty is defined as a clinically recognizable state of increased vulnerability to physiologic stressors resulting from aging. Frailty is associated with a decline in physiologic reserve and function across multiple physiologic systems. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. Unlike cachexia, which is typically associated with weight loss due to chemotherapy or a general malignancy-related cachexia syndrome, sarcopenia relates to muscle mass rather than simply weight. As such, while weight reflects nutritional status, sarcopenia- the loss of muscle mass- is a more accurate and quantitative global marker of frailty. While chronologic age is an important element in assessing a patient's peri-operative risk, physiologic age is a more important determinant of outcomes. Geriatric assessment tools are important components of the preoperative work-up and can help identify patients who suffer from frailty. Such data are important, as frailty and sarcopenia have repeatedly been demonstrated among the strongest predictors of both short- and longterm outcome following complicated surgical procedures such as esophageal, gastric, colorectal, and hepatopancreatico-biliary resections. | doris wagner mara mcadams demarco neda amini stefan buttner dorry segev faiz gani timothy m pawlik | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 8 |
| 2 | What are the evolutionary origins of stomatal responses to abscisic acid in land plants?显示文摘The evolution of active stomatal closure in response to leaf water deficit,mediated by the hormone abscisic acid(ABA),has been the subject of recent debate.Two different models for the timing of the evolution of this response recur in the literature.A single-step model for stomatal control suggests that stomata evolved active,ABAmediated control of stomatal aperture,when these structures first appeared,prior to the divergence of bryophyte and vascular plant lineages.In contrast,a gradualistic model for stomatal control proposes that the most basal vascular plant stomata responded passively to changes in leaf water status.This model suggests that active ABA-driven mechanisms for stomatal responses to water status instead evolved after the divergence of seed plants,culminating in the complex,ABA-mediated responses observed in modern angiosperms.Here we review the findings that form the basis for these two models,including recent work that provides critical molecular insights into resolving this intriguing debate,and find strong evidence to support a gradualistic model for stomatal evolution. | Frances C. Sussmilch Timothy J. Brodribb Scott A. M. McAdam | 2017 | Journal of Integrative Plant Biology2017，59，4： | 3 |
| 3 | Personality Development: Continuity and Change Over the Life Course显示文摘 | Dan P. McAdams Bradley D. Olson | 2010 | Annual Review of Psychology2010，，： | 2 |
| 4 | 拉·维莱特公园显示文摘1983年,伯纳德·屈米建筑师事务所从470支团队里脱颖而出,赢得了巴黎拉。维莱特公园国际设计竞赛。该项目同新法国国家图书馆、卢浮宫金字塔、拉德芳斯新凯旋门和阿拉伯世界研究中心等项目一样,是当时法国政府主持的几大工程之一。那次设计竞赛的目标是表达时代愿景,推动项目所处的巴黎关键区域未来经济和文化的发展。 | bernard tschumi luca merlini alexandra villegas luca pagnamenta jon olsen jean-franCois erhel ursula kurz christian biecher marie-line luquet neil porter steve mcadam jean-pierre nourry didier pasquier renzo bader | 2016 | 城市环境设计2016，0，1： | 2 |
| 5 | Prospects for non-thermal atmospheric plasmas for pollution abatement 显示文摘 | Mcadams R | 2001 | Physics D: Applied Physics2001，34，： | 2 |
| 6 | The TB pandemic:an old problem seeking new solutions显示文摘 | Meya DB McAdam KP | 2004 | J Intern Med2004，261，4： | 1 |
| 7 | Computed tomography diagnosis of macroscopic pulmonary fat embolism显示文摘 | RAVENEL J G HEYNEMAN L E McADAMS H P | 2002 | J Thorac Imaging2002，17，2： | 1 |
| 8 | Multidimensional imaging of the thorax: practical applications 显示文摘 | Ravenel JG McAdams HP Remy-Jardin M | 2001 | Thorac Imaging2001，16，4： | 1 |
| 9 | Stochastic kinetic analysis of developmental pathway bifurcation in phage lambda-infected Escherichia coli cells 显示文摘 | Arkin A Ross J McAdams HH | 1998 | Genetics1998，149，4： | 1 |
| 10 | Spray Drying and Vaccine Stabilization 显示文摘 | MCADAMS D CHEN D KRISTENSEN D | 2012 | Expert Rev Vaccines2012，11，10： | 1 |
| 11 | Symptom experiences of family members of intensive care unit patients at high risk for dying显示文摘 | Mcadam JL Dracup KA White DB | 2010 | Crit Care Med2010，38，4： | 1 |
| 12 | Factor substitution and factoraugmenting technical progress in the united states: a normalized supplyside system approach显示文摘 | Klump R McAdam P Willman A | 2007 | Review of Economics and Statistics2007，89，： | 1 |
| 13 | OX40-ligand has a critical costimulatory role in dendritic cell:T cell interactions显示文摘 | Chen AI McAdam AJ Buhlmann JE | 1999 | Immunity1999，11，6： | 1 |
| 14 | Bronchogenic cyst:imaging features with clinical and histopathologic correlation显示文摘 | McAdams HP Kirejczyk WM Rosado-de-Christenson ML | 2000 | Radiology2000，217，2： | 1 |
| 15 | Can computer aided teaching packages improve clinical care in patients with acute abdominal pain显示文摘 | de Dombal FT Dallos V McAdam WA | 1991 | BMJ1991，302，6791： | 1 |
| 16 | Bronchogenic Cyst:Imaging Features with Clinical and Histopathologic Correlation显示文摘 | McAdams H P Kirejczyk W M Rosado-de-Christenson M L | 2000 | Radiology2000，217，2： | 1 |
| 17 | Cross-reactive recognition If p55 by cytotoxic T lymphocytes in HIV-1 infection显示文摘 | McAdam S Kaleebu P Krausa P | 1998 | AIDS1998，12，6： | 1 |
| 18 | Castleman disease of the thorax: radiologic features with clinlcal and histopathologic correlation显示文摘 | MCADAMS H P BOSADO-DE-CHRISTENSON M FISHBACK N F | 1998 | Radiology1998，209，1： | 1 |
| 19 | Perspectives on the contribution of timbre to musical structure显示文摘 | McAdams S | 1999 | Computer Music Jouma/1999，23，3： | 1 |
| 20 | Pulmonary mucorrnycosis:radiologic findings in 32 cases显示文摘 | McAdams HP Rosado de Christenson M Strollo DC | 1997 | AJR Am J Roentgenol1997，168，： | 1 |
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